Protective effect of Z-ligustilide against amyloid β-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains

Pharmacology Biochemistry and Behavior

Volumn 92, Issue 4, 2009, Pages 635-641

  Kuang, Xi ^a,b,c   Du, Jun Rong ^a,b,c   Chen, Ya Shu ^a,b,c   Wang, Jing ^a,b,c   Wang, Yan Nan ^a,b,c  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Alzheimer's disease (AD),; Amyloid 25 35,; Morris water maze; Neuroinflammatory response; Z ligustilide (LIG),

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; AMYLOID PRECURSOR PROTEIN; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGUSTILIDE; NEUROPROTECTIVE AGENT; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HIPPOCAMPUS; IMMUNOREACTIVITY; INFLAMMATION; MALE; MAZE TEST; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; SIGNAL TRANSDUCTION;

4-BUTYROLACTONE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; NEUROPROTECTIVE AGENTS; NF-KAPPA B; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 67349157086     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2009.03.007     Document Type: Article

References (34)

1. Akama K.T., Albanese C., Pestell R.G., and Van Eldik L.J. Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism. Proc Natl Acad Sci U S A 95 (1998) 5795-5800
2. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.M., et al. Inflammation and Alzheimer's disease. Neurobiol Aging 21 (2000) 383-421
3. Bales K.R., Du Y., Dodel R.C., Yan G.M., Hamilton-Byrd E., and Paul S.M. The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation. Mol Brain Res 57 (1998) 63-72
4. Bales K.R., Du Y., Holtzman D., Cordell B., and Paul S.M. Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Aβ-induced glial activation, NF-κB, and apolipoprotein E. Neurobiol Aging 21 (2000) 427-432
5. Bussière T., Giannakopoulos P., Bouras C., Perl D.P., Morrison J.H., and Hof P.R. Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9. J Comp Neurol 463 (2003) 281-302
6. Cheng G., Whitehead S.N., Hachinski V., and Cechetto D.F. Effects of pyrrolidine dithiocarbamate on Aβ (25-35)-induced inflammatory responses and memory deficits in the rat. Neurobiol Dis 23 (2006) 140-151
7. Colton C.A., Chernyshev O.N., Gilbert D.L., and Vitek M.P. Microglial contribution to oxidative stress in Alzheimer's disease. Ann N Y Acad Sci 899 (2000) 292-307
8. Eikelenboom P., Veerhuis R., Familian A., Hoozemans J.J., van Gool W.A., and Rozemuller A.J. Neuroinflammation in plaque and vascular β-amyloid disorders: clinical and therapeutic implications. Neurodegener Dis 5 (2008) 190-193
9. Gomez-Isla T., Price J.L., McKeel Jr. D.W., Morris J.C., Growdon J.H., and Hyman B.T. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16 (1996) 4491-4500
10. Hirohata M., Ono K., and Yamada M. Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Curr Pharm Des 14 (2008) 3280-3294
11. Hu J., and Van Eldik L.J. Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation. Brain Res 842 (1999) 46-54
12. Huang H.C., and Jiang Z.F. Accumulated amyloid-beta peptide and hyperphosphorylated Tau protein: relationship and links in Alzheimer's disease. J Alzheimers Dis 16 (2009) 15-27
13. Husain M.M., Trevino K., Siddique H., and McClintock S.M. Present and prospective clinical therapeutic regimens for Alzheimer's disease. Neuropsychiatric Dis Treat 4 (2008) 765-777
14. 25-35. Neurosci 145 (2007) 209-224
15. Kosik K.S., Joachim C.L., and Selkoe D.J. Microtubule-associated protein tau (τ) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A 83 (1986) 4044-4048
16. Kuang X., Yao Y., Du J.R., Liu Y.X., Wang C.Y., and Qian Z.M. Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice. Brain Res 1102 (2006) 145-153
17. Kuang X., Du J.R., Liu Y.X., Zhang G.Y., and Peng H.Y. Postischemic administration of Z-ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacol Biochem Behav 88 (2008) 213-221
18. Kucukatay V., Balkan S., Yaras N., Yargicoglu P., and Agar A. The effect of pergolide on cognitive performance of young and middle-aged rats. Int J Neurosci 112 (2002) 1027-1036
19. Lin M., Zhu G.D., Sun Q.M., and Fang Q.C. Chemical studies of Angelica sinensis. Acta Pharmceut Sin 14 (1979) 529-534
20. Liu L., Ning Z.Q., Shan S., Zhang K., Deng T., Lu X.P., et al. Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-α production and TNF-α-mediated NF-κB activation. Planta Med 71 (2005) 808-813
21. McGeer P.L., and McGeer E.G. Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22 (2001) 799-809
22. Morris R. Developments of a water maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1984) 47-60
23. Moser M.B., Moser E.I., Forrest E., Andersen P., and Morris R.G. Spatial learning with a minislab in the dorsal hippocampus. Proc Natl Acad Sci U S A 92 (1995) 9697-9701
24. Naito T., Ikeya Y., Okada M., Mistuhashi H., and Maruno M. Two phthalides from Ligusticum chuanxiong. Phytochemistry 41 (1996) 233-236
25. Ono K., Hamaguchi T., Naiki H., and Yamada M. Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease. Biochem Biophys Acta 1762 (2006) 575-586
26. Pasinetti G.M. From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in β-amyloidosis and clinical dementia. Alzheimers Dis 4 (2002) 435-445
27. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd edn (1997), Academic Press, San Diego
28. Peng H.Y., Du J.R., Zhang G.Y., Kuang X., Liu Y.X., Qian Z.M., et al. Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats. Biol Pharm Bull 30 (2007) 309-312
29. Selkoe D.J., Abraham C.R., Podlisny M.B., and Duffy L.K. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem 46 (1986) 1820-1834
30. 1-42 reduced dopamine levels in rat prefrontal cortex: relationship to nitric oxide. Neurosci 147 (2007) 652-663
31. Walsh D.M., Klyubin I., Fadeeva J.V., Roman M.J., and Selkoe D.J. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans 30 (2002) 552-557
32. West M.J., Coleman P.D., Flood D.G., and Troncoso J.C. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344 (1994) 769-772
33. Whitehead S.N., Hachinski V.C., and Cechetto D.F. Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: inflammatory responses. Stroke 36 (2005) 107-112
34. Yu Y., Du J.R., Wang C.Y., and Qian Z.M. Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells. Exp Brain Res 184 (2008) 307-312