Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion

Haematologica

Volumn 97, Issue 7, 2012, Pages 989-993

  Danjou, Fabrice ^a   Anni, Franco ^a   Perseu, Lucia ^b   Satta, Stefania ^a   Dessì, Carlo ^a   Lai, Maria Eliana ^c   Fortina, Paolo ^d,e   Devoto, Marcella ^e,f,g   Galanello, Renzo ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

^c Osp Regionale per le Microcitemie   (Italy)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Beta thalassemia; Fetal hemoglobin; Genetic modifiers; Thalassemia intermedia; Thalassemia major

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HEMOGLOBIN F; HEPATITIS B SURFACE ANTIGEN; SPACER DNA;

ADULT; AGE; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; DISEASE SEVERITY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENOTYPE; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MODIFIER GENE; ONCOGENE MYB; PHENOTYPE; PROPORTIONAL HAZARDS MODEL; QUALITY CONTROL; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGE FACTORS; ALPHA-GLOBINS; BETA-GLOBINS; BETA-THALASSEMIA; BLOOD TRANSFUSION; CARRIER PROTEINS; COHORT STUDIES; DNA FINGERPRINTING; DNA, INTERGENIC; FEMALE; FETAL HEMOGLOBIN; GENETIC LOCI; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 84862901436     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.053504     Document Type: Article

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