Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: Evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis

Archives of Toxicology

Volumn 86, Issue 4, 2012, Pages 603-614

  Kunwar, A ^a   Jayakumar, S ^a   Srivastava, A K ^a   Priyadarsini, K I ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Apoptosis; Cell cycle arrest; Dimethoxycurcumin; Mitochondrial dysfunction; Oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CELL CYCLE PROTEIN; CURCUMIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; DIMETHOXYCURCUMIN; GLUTATHIONE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASSAY; BREAST CARCINOMA; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DEATH; CELL ENERGY; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME REPRESSION; ENZYME SUBUNIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROOXIDANT ACTIVITY; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; CURCUMIN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; S PHASE CELL CYCLE CHECKPOINTS;

EID: 84862878893     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0786-y     Document Type: Article

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