Expression of multidrug resistance-associated proteins in paediatric soft tissue sarcomas before and after chemotherapy

International Journal of Oncology

Volumn 41, Issue 1, 2012, Pages 117-124

  Citti, Arianna ^a   Boldrini, Renata ^a   Inserra, Alessandro ^a   Alisi, Anna ^a   Pessolano, Rosanna ^a   Mastronuzzi, Angela ^a   Zin, Angelica ^b   De Sio, Luigi ^a   Rosolen, Angelo ^b   Locatelli, Franco ^a,c   Fruci, Doriana ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

Chemotherapy resistance; Multidrug resistance; Multidrug resistance associated proteins; Paediatric tumours; Soft tissue sarcomas

Indexed keywords

COMPLEMENTARY DNA; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; RNA;

ADOLESCENT; ARTICLE; CANCER CHEMOTHERAPY; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MULTIDRUG RESISTANCE; NEWBORN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOFT TISSUE SARCOMA; TUMOR CELL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION; HEAD AND NECK NEOPLASMS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ONCOGENE PROTEINS, FUSION; P-GLYCOPROTEIN; P-GLYCOPROTEINS; SARCOMA; STATISTICS, NONPARAMETRIC; UROGENITAL NEOPLASMS;

EID: 84862878619     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1433     Document Type: Article

References (40)

1. Jain S, Xu R, Prieto VG and Lee P: Molecular classification of soft tissue sarcomas and its clinical applications. Int J Clin Exp Pathol 3: 416-428, 2010.
2. Huh WW and Skapek SX: Childhood rhabdomyosarcoma: new insight on biology and treatment. Curr Oncol Rep 12: 402-410, 2010.
3. Klunder JW, Komdeur R, van Der Graaf WT, et al: Expression of multidrug resistance-associated proteins in rhabdomyosarcomas before and after chemotherapy: the relationship between lung resistance-related protein (LRP) and differentiation. Hum Pathol 34: 150-155, 2003. (Pubitemid 36258806)
4. Colvin OM: Drug resistance in the treatment of sarcomas. Semin Oncol 24: 580-591, 1997.
5. Gerlach JH, Bell DR, Karakousis C, et al: P-glycoprotein in human sarcoma: evidence for multidrug resistance. J Clin Oncol 5: 1452-1460, 1987.
6. Robert J: Multidrug resistance in oncology: diagnostic and therapeutic approaches. Eur J Clin Invest 29: 536-545, 1999.
7. Yoshikawa M, Ito A, Ishikawa T and Ikegami Y: [Drug resistance mediated by ABC transporters]. Gan To Kagaku Ryoho 31: 1-6, 2004.
8. Melguizo C, Prados J, Rama AR, et al: Multidrug resistance and rhabdomyosarcoma (Review). Oncol Rep 26: 755-761, 2011.
9. Baguley BC: Multiple drug resistance mechanisms in cancer. Mol Biotechnol 46: 308-316, 2010.
10. Higgins CF: ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113, 1992.
11. Leonard GD, Fojo T and Bates SE: The role of ABC transporters in clinical practice. Oncologist 8: 411-424, 2003. (Pubitemid 37238869)
12. Gottesman MM, Pastan I and Ambudkar SV: P-glycoprotein and multidrug resistance. Curr Opin Genet Dev 6: 610-617, 1996. (Pubitemid 26372158)
13. Cole SP and Deeley RG: Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP. Bioessays 20: 931-940, 1998. (Pubitemid 28554038)
14. Nooter K, Sonneveld P, Janssen A, et al: Expression of the mdr3 gene in prolymphocytic leukemia: association with cyclosporin-A-induced increase in drug accumulation. Int J Cancer 45: 626-631, 1990. (Pubitemid 20146119)
15. Herweijer H, Sonneveld P, Baas F and Nooter K: Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. J Natl Cancer Inst 82: 1133-1140, 1990. (Pubitemid 20213254)
16. Norris MD, Burkhart CA, Marshall GM, Weiss WA and Haber M: Expression of N-myc and MRP genes and their relationship to N-myc gene dosage and tumor formation in a murine neuroblastoma model. Med Pediatr Oncol 35: 585-589, 2000.
17. Shapiro DN, Sublett JE, Li B, Downing JR and Naeve CW: Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res 53: 5108-5112, 1993. (Pubitemid 23333374)
18. Norris MD, Bordow SB, Marshall GM, Haber PS, Cohn SL and Haber M: Expression of the gene for multidrug-resistance-passociated protein and outcome in patients with neuroblastoma. N Engl J Med 334: 231-238, 1996. (Pubitemid 26032215)
19. Warmann SW, Heitmann H, Teichmann B, et al: Effects of P-glycoprotein modulation on the chemotherapy of xenotransplanted human hepatoblastoma. Pediatr Hematol Oncol 22: 373-386, 2005. (Pubitemid 40993600)
20. Komdeur R, Klunder J, van der Graaf WT, et al: Multidrug resistance proteins in rhabdomyosarcomas: comparison between children and adults. Cancer 97: 1999-2005, 2003. (Pubitemid 36397278)
21. Sola JE, Wojno KJ, Dooley W and Colombani PM: P-glycoprotein status of favorable-histology Wilms' tumor predicts treatment outcome. J Pediatr Surg 29: 1080-1084, 1994. (Pubitemid 24265651)
22. Komdeur R, Plaat BE, van der Graaf WT, et al: Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade. Eur J Cancer 39: 909-916, 2003. (Pubitemid 36428622)
23. Flens MJ, Zaman GJ, van der Valk P, et al: Tissue distribution of the multidrug resistance protein. Am J Pathol 148: 1237-1247, 1996. (Pubitemid 26111082)
24. Crist WM, Anderson JR, Meza JL, et al: Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 19: 3091-3102, 2001. (Pubitemid 32567502)
25. Orbach D, Rey A, Oberlin O, et al: Soft tissue sarcoma or malignant mesenchymal tumors in the first year of life: experience of the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Committee. J Clin Oncol 23: 4363-4371, 2005. (Pubitemid 46207010)
26. Sartori F, Alaggio R, Zanazzo G, et al: Results of a prospective minimal disseminated disease study in human rhabdomyosarcoma using three different molecular markers. Cancer 106: 1766-1775, 2006.
27. Argani P, Fritsch M, Kadkol SS, Schuster A, Beckwith JB and Perlman EJ: Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. Mod Pathol 13: 29-36, 2000. (Pubitemid 30077901)
28. Nilsson G, Skytting B, Xie Y, et al: The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res 59: 3180-3184, 1999. (Pubitemid 29316020)
29. Camassei FD, Ferlini C, Jenkner A, et al: Nephroblastoma. DNA characteristics and their modifications induced by prenephrectomy chemotherapy: a cytofluorimetric study. Pediatr Pathol Mol Med 21: 15-23, 2002. (Pubitemid 34142848)
30. Chan HS, Thorner PS, Haddad G and Ling V: Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. J Clin Oncol 8: 689-704, 1990. (Pubitemid 20127254)
31. De Cremoux P, Jourdan-Da-Silva N, Couturier J, et al: Role of chemotherapy resistance genes in outcome of neuroblastoma. Pediatr Blood Cancer 48: 311-317, 2007. (Pubitemid 46238522)
32. Oda Y, Schneider-Stock R, Rys J, Gruchala A, Niezabitowski A and Roessner A: Reverse transcriptase-polymerase chain reaction amplification of MDR1 gene expression in adult soft tissue sarcomas. Diagn Mol Pathol 5: 98-106, 1996. (Pubitemid 26156458)
33. Nakanishi H, Myoui A, Ochi T and Aozasa K: P-glycoprotein expression in soft-tissue sarcomas. J Cancer Res Clin Oncol 123: 352-356, 1997. (Pubitemid 27286509)
34. Kuttesch JF, Parham DM, Luo X, et al: P-glycoprotein expression at diagnosis may not be a primary mechanism of therapeutic failure in childhood rhabdomyosarcoma. J Clin Oncol 14: 886-900, 1996.
35. Gallego S, Llort A, Parareda A and Sanchez De Toledo J: Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma. Oncol Rep 11: 179-183, 2004.
36. Oue T, Yoneda A, Uehara S, Yamanaka H and Fukuzawa M: Increased expression of multidrug resistance-associated genes after chemotherapy in pediatric solid malignancies. J Pediatr Surg 44: 377-380, 2009.
37. Wang Q and Beck WT: Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53. Cancer Res 58: 5762-5769, 1998. (Pubitemid 29006417)
38. Cocker HA, Hobbs SM, Tiffin N, Pritchard-Jones K, Pinkerton CR and Kelland LR: High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance. Br J Cancer 85: 1746-1752, 2001. (Pubitemid 34081522)
39. Izquierdo M: Short interfering RNAs as a tool for cancer gene therapy. Cancer Gene Ther 12: 217-227, 2005.
40. Ho EA and Piquette-Miller M: Regulation of multidrug resistance by pro-inflammatory cytokines. Curr Cancer Drug Targets 6: 295-311, 2006. (Pubitemid 43961865)