The potential of trefoil proteins as biomarkers in human cancer

Biomarkers in Medicine

Volumn 6, Issue 3, 2012, Pages 301-304

  May, Felicity Eb ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

adenocarcinoma; androgen receptor; estrogen receptor; HER2; predictive; prognostic; stratified medicine; TFF1; TFF2; TFF3; trefoil factor

Indexed keywords

BIOLOGICAL MARKER; PROTEIN TFF1; PROTEIN TFF2; PROTEIN TFF3; TREFOIL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CANCER PROGNOSIS; CARCINOGENESIS; HORMONAL THERAPY; HUMAN; METASTASIS; NONHUMAN; ONCOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN STRUCTURE; REVIEW; TREATMENT RESPONSE;

HUMANS; NEOPLASMS; PEPTIDES; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

LOTUS;

EID: 84862870917     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm.12.22     Document Type: Review

References (24)

1. Beatson GT. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases. Lancet 11148(3802), 104-107 (1896).
2. May FEB, Westley BR. Trefoil proteins: their role in normal and malignant cells. J. Pathol. 183(1), 4-7 (1997).
3. Thim L, May F.E.B. Structure of mammalian trefoil factors and functional insights. Cell. Mol. Life Sci. 62(24), 2956-2973 (2005).
4. May FEB, Church ST, Major S, Westley BR. The closely related estrogen-regulated trefoil proteins TFF1 and TFF3 have markedly different hydrodynamic properties, overall charge, and distribution of surface charge. Biochemistry 42(27), 8250-8259 (2003).
5. Chadwick MP, Westley BR, May F.E.B. Homodimerization and heterooligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine Biochem. J. 327(Pt 1), 117-123 (1997).
6. Westley BR, Griffin SM, May F.E.B. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 44(22), 7967-7975 (2005).
7. Lefebvre O, Chenard MP, Masson R et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 274(5285), 259-262 (1996).
8. Masiakowski P, Breathnach R, Bloch J, Gannon F, Krust A, Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res. 10(24), 7895-7903 (1982).
9. May FEB, Westley BR. Expression of human intestinal trefoil factor in malignant cells and its regulation by oestrogen in breast cancer cells. J. Pathol. 182(4), 404-413. (1997).
10. Dhar DK, Wang TC, Tabara H et al. Expression of trefoil factor family members correlates with patient prognosis and neoangiogenesis. Clin. Cancer Res. 11(18), 6472-6478 (2005).
11. Ahmed AR, Griffiths AB, Tilby MJ, Westley BR, May F.E.B. TFF3 is a normal breast epithelial protein and is associated with differentiated phenotype in early breast cancer but predisposes to invasion and metastasis in advanced disease. Am. J. Pathol. 180(3), 904-916 (2012).
12. Arumugam T, Brandt W, Ramachandran V et al. Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis. Pancreas 40(6), 815-822 (2011).
13. Smid M, Wang Y, Klijn JGM et al. Genes associated with breast cancer metastatic to bone. J. Clin. Oncol. 24(15), 2261-2267 (2006).
14. Henry JA, Bennett MK, Piggott NH, Levett DL, May FEB, Westley BR. Expression of the pNR-2/pS2 protein in diverse human epithelial tumors. Br. J. Cancer. 64(4), 677-682 (1991).
15. Lee O, Helenowski IB, Chatterton RT Jr, Jovanovic B, Khan SA. Prediction of menopausal status from estrogen-related gene expression in benign breast tissue. Breast Cancer Res. Treat. 131(3), 1067-1076. (2012).
16. Buache E, Etique N, Alpy F et al. Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice. Oncogene 30(29), 3261-3273 (2011).
17. Yamachika T, Werther JL, Bodian C et al. Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma. Clin. Cancer Res. 8(5), 1092-1099 (2002).
18. Mikhitarian K, Gillanders WE, Almeida JS et al. An innovative microarray strategy identities informative molecular markers for the detection of micrometastatic breast cancer. Clin. Cancer Res. 11(10), 3697-3704 (2005).
19. Crosier M, Scott D, Wilson RG, Griffith CDM, May FEB, Westley BR. High expression of the trefoil protein TFF1 in interval breast cancers. Am. J. Pathol. 159(1), 215-221 (2001).
20. Prest SJ, May FEB, Westley BR. The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells. FASEB J. 16(6), 592-594 (2002).
21. May FEB, Griffin SM, Westley BR. The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer. Int. J. Biochem. Cell Biol. 41(3), 632-640 (2009).
22. Henry JA, Piggott NH, Mallick UK et al. pNR-2/pS2 immunohistochemical staining in breast cancer: correlation with prognostic factors and endocrine response. Br. J. Cancer. 63(4), 615-622 (1991).
23. Foekens JA, Portengen H, Look MP et al. Relationship of PS2 with response to tamoxifen therapy in patients with recurrent breast cancer. Br. J. Cancer. 70(6), 1217-1223 (1994).
24. Rickman DS, Chen YB, Banerjee S et al. ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression. Neoplasia 12(12), 1031-1040 (2010).