TFF3 is a normal breast epithelial protein and is associated with differentiated phenotype in early breast cancer but predisposes to invasion and metastasis in advanced disease

American Journal of Pathology

Volumn 180, Issue 3, 2012, Pages 904-916

  Ahmed, Ahmed R H ^a,c   Griffiths, Andrew B ^d   Tilby, Michael T ^a   Westley, Bruce R ^a,b   May, Felicity E B ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c Sohag University   (Egypt)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD34 ANTIGEN; ESTROGEN; ESTROGEN RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; PROGESTERONE RECEPTOR; PROTEIN TFF3; TREFOIL PEPTIDE; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST DISEASE; BREAST DUCT; BREAST EPITHELIUM; CANCER CELL; CANCER GRADING; CANCER INVASION; CARCINOMA IN SITU; CELL DIFFERENTIATION; CELL INFILTRATION; CELL POLARITY; EARLY CANCER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; LYMPH NODE METASTASIS; METASTASIS; PAPILLOMA; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; STROMA;

ADOLESCENT; ADULT; BREAST; BREAST NEOPLASMS; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDES; PHENOTYPE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84857234036     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.11.022     Document Type: Article

References (37)

1. F.E.B. May, B.R. Westley Trefoil proteins: their role in normal and malignant cells J Pathol 183 1997 4 7
2. L. Thim, F.E.B. May Structure of mammalian trefoil factors and functional insights Cell Mol Life Sci 62 2005 2956 2973
3. F.E.B. May, S.T. Church, S. Major, B.R. Westley The closely related estrogen-regulated trefoil proteins TFF1 and TFF3 have markedly different hydrodynamic properties, overall charge, and distribution of surface charge Biochemistry 42 2003 8250 8259
4. F.W. Muskett, F.E.B. May, B.R. Westley, J. Feeney Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins Biochemistry 42 2003 15139 15147
5. M.A. Williams, B.R. Westley, F.E.B. May, J. Feeney The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF1 FEBS Lett 493 2001 70 74
6. S. Emami, N. Le Floch, E. Bruyneel, L. Thim, F. May, B. Westley, M. Rio, M. Mareel, C. Gespach Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells FASEB J 15 2001 351 361
7. S. Rodrigues, E. Van Aken, S. Van Bocxlaer, S. Attoub, Q.D. Nguyen, E. Bruyneel, B.R. Westley, F.E.B. May, L. Thim, M. Mareel, C. Gespach, S. Emami Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signalling FASEB J 17 2003 7 16
8. O. Lefebvre, M.P. Chenard, R. Masson, J. Linares, A. Dierich, M. LeMeur, C. Wendling, C. Tomasetto, P. Chambon, M.C. Rio Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein Science 274 1996 259 262
9. J.A. Foekens, M.C. Rio, P. Seguin, W.L. van Putten, J. Fauque, M. Nap, J.G.M. Klijn, P. Chambon Prediction of relapse and survival in breast cancer patients by pS2 protein status Cancer Res 50 1990 3832 3837
10. A.M. Thompson, R.A. Elton, R.A. Hawkins, U. Chetty, C.M. Steel PS2 mRNA expression adds prognostic information to node status for 6-year survival in breast cancer Br J Cancer 77 1998 492 496
11. T. Yamachika, J.L. Werther, C. Bodian, M. Babyatsky, M. Tatematsu, Y. Yamamura, A. Chen, S. Itzkowitz Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma Clin Cancer Res 8 2002 1092 1099
12. D.K. Dhar, T.C. Wang, H. Tabara, Y. Tonomoto, R. Maruyama, M. Tachibana, H. Kubota, N. Nagasue Expression of trefoil factor family members correlates with patient prognosis and neoangiogenesis Clin Cancer Res 11 2005 6472 6478
13. X. Yio, J.Y. Zhang, M. Babyatsky, A. Chen, J. Lin, Q.X. Fan, J.L. Werther, S. Itzkowitz Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells Clin Exp Metastasis 22 2005 157 165
14. M. Babyatsky, J. Lin, X. Yio, A. Chen, J.Y. Zhang, Y. Zheng, C. Twyman, X. Bao, M. Schwartz, S. Thung, J. Lawrence Werther, S. Itzkowitz Trefoil factor-3 expression in human colon cancer liver metastasis Clin Exp Metastasis 26 2009 143 151
15. P. Masiakowski, R. Breathnach, J. Bloch, F. Gannon, A. Krust, P. Chambon Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line Nucleic Acids Res 10 1982 7895 7903
16. F.E.B. May, B.R. Westley Cloning of estrogen-regulated messenger RNA sequences from human breast cancer cells Cancer Res 46 12 Pt 1 1986 6034 6040
17. F.E.B. May, B.R. Westley Identification and characterization of estrogen-regulated RNAs in human breast cancer cells J Biol Chem 263 1988 12901 12908
18. F.E.B. May, J.I. Semple, S.J. Prest, B.R. Westley Expression and motogenic activity of TFF2 in human breast cancer cells Peptides 25 2004 865 872
19. R. Poulsom, A.M. Hanby, E.N. Lalani, F. Hauser, W. Hoffmann, G.W.H. Stamp Intestinal trefoil factor (TFF 3) and pS2 (TFF 1), but not spasmolytic polypeptide (TFF 2) mRNAs are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium J Pathol 183 1997 30 38
20. F.E.B. May, B.R. Westley Expression of human intestinal trefoil factor in malignant cells and its regulation by oestrogen in breast cancer cells J Pathol 182 1997 404 413
21. S. Gruvberger, M. Ringnr, Y. Chen, S. Panavally, L.H. Saal, A. Borg, M. Fern, C. Peterson, P.S. Meltzer Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns Cancer Res 61 2001 5979 5984
22. M. West, C. Blanchette, H. Dressman, E. Huang, S. Ishida, R. Spang, H. Zuzan, J.R. Olson JA, J.R. Marks, J.R. Nevins Predicting the clinical status of human breast cancer by using gene expression profiles Proc Natl Acad Sci U S A 98 2001 11462 11467
23. B.R. Westley, S.M. Griffin, F.E.B. May Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C Biochemistry 44 2005 7967 7975
24. E.M. Vestergaard, E. Nexo, A. Wendt, F. Guthmann Trefoil factors in human milk Early Hum Dev 84 2008 631 635
25. P.M. Vogel, N.G. Georgiade, B.F. Fetter, F.S. Vogel, K.S. McCarty Jr The correlation of histologic changes in the human breast with the menstrual cycle Am J Pathol 104 1981 23 34
26. R. Ramakrishnan, S.A. Khan, S. Badve Morphological changes in breast tissue with menstrual cycle Mod Pathol 15 2002 1348 1356
27. R. Yerushalmi, R. Woods, P.M. Ravdin, M.M. Hayes, K.A. Gelmon Ki67 in breast cancer: prognostic and predictive potential Lancet Oncol 11 2010 174 183
28. D.C. Allred Issues and updates: evaluating estrogen receptor-alpha, progesterone receptor, and HER2 in breast cancer Mod Pathol 23 Suppl 2 2010 S52 S59
29. J.A. Henry, N.H. Piggott, U.K. Mallick, S. Nicholson, J.R. Farndon, B.R. Westley, F.E.B. May Prediction of relapse and survival in breast cancer patients by pS2 protein status Br J Cancer 63 1991 615 622
30. N.H. Piggott, J.A. Henry, F.E.B. May, B.R. Westley Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry J Pathol 163 1991 95 104
31. H. Uchino, H. Kataoka, H. Itoh, R. Hamasuna, M. Koono Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo Gastroenterology 118 2000 60 69
32. D.X. Nguyen, P.D. Bos, J. Massagu Metastasis: from dissemination to organ-specific colonization Nat Rev Cancer 9 2009 274 284
33. M. Smid, Y. Wang, J.G.M. Klijn, A.M. Sieuwerts, Y. Zhang, D. Atkins, J.W.M. Martens, J.A. Foekens Genes associated with breast cancer metastatic to bone J Clin Oncol 24 2006 2261 2267
34. F.E.B. May, S.M. Griffin, B.R. Westley The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer Int J Biochem Cell Biol 41 2009 632 640
35. C.L. Wilson, A.H. Sims, A. Howell, C.J. Miller, R.B. Clarke Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue Endocr Relat Cancer 13 2006 617 628
36. P.K. Wright, F.E.B. May, S. Darby, R. Saif, T.W.J. Lennard, B.R. Westley Estrogen regulates vesicle trafficking gene expression in EFF-3 EFM-19 and MCF-7 breast cancer cells Int J Clin Exp Pathol 2 2009 463 475
37. I.J. Diel, E.F. Solomayer, S.D. Costa, C. Gollan, R. Goerner, D. Wallwiener, M. Kaufmann, G. Bastert Reduction in new metastases in breast cancer with adjuvant clodronate treatment N Engl J Med 339 1998 357 363