The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 3, 2009, Pages 632-640

  May, Felicity E B ^a,b   Griffin, S Michael ^c   Westley, Bruce R ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

Gastric cancer; Gastric mucosa; Metastasis; TFIZ1; Trefoil proteins

Indexed keywords

TREFOIL PEPTIDE; TREFOIL PROTEIN TFF1; TREFOIL PROTEIN TFF2; TREFOIL PROTEIN TFF3; TREFOIL PROTEIN TFIZ1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LYMPH NODE METASTASIS; MOUSE; MUCOUS CELL; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STOMACH; STOMACH CANCER; STOMACH MUCOSA;

AMINO ACID SEQUENCE; CARRIER PROTEINS; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; ORGAN SPECIFICITY; PEPTIDES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

LOTUS;

EID: 58149461141     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.07.015     Document Type: Article

References (52)

1. Baus-Loncar M., Lubka M., Pusch C.M., Otto W.R., Poulsom R., and Blin N. Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells. Cell Physiol Biochem 20 (2007) 193-204
2. Beckler A.D., Roche J.K., Harper J.C., Petroni G., Frierson Jr. H.F., Moskaluk C.A., et al. Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas. Cancer 98 (2003) 2184-2191
3. Bossenmeyer-Pourie C., Kannan R., Ribieras S., Wendling C., Stoll I., Thim L., et al. The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis. J Cell Biol 157 (2002) 761-770
4. Carvalho R., Kayademir T., Soares P., Canedo P., Sousa S., Oliveira C., et al. Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma. Lab Invest 82 (2002) 1319-1326
5. Chadwick M.P., May F.E.B., and Westley B.R. Production and comparison of mature single-domain 'trefoil' peptides pNR-2/pS2 Cys58 and pNR-2/pS2 Ser58. Biochem J 308 Pt 3 (1995) 1001-1007
6. Chadwick M.P., Westley B.R., and May F.E.B. Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. Biochem J 327 Pt 1 (1997) 117-123
7. Clyne M., Dillon P., Daly S., O'Kennedy R., May F.E.B., Westley B.R., et al. Helicobacter pylori interacts with the human single-domain trefoil protein TFF1. Proc Natl Acad Sci USA 101 (2004) 7409-7414
8. Crosier M., Scott D., Wilson R.G., Griffiths C.D., May F.E.B., and Westley B.R. High expression of the trefoil protein TFF1 in interval breast cancers. Am J Pathol 159 (2001) 215-221
9. Du J.J., Dou K.F., Peng S.Y., Li J.T., Wang W.Z., Guan W.X., et al. Study on novel gene GDDR related to gastric cancer. Zhonghua Wai Ke Za Zhi 43 (2005) 10-13
10. Du J.J., Dou K.F., Peng S.Y., Wang W.Z., Wang Z.H., Xiao H.S., et al. Down-regulated full-length novel gene GDDR and its effect on gastric cancer. Zhonghua Yi Xue Za Zhi 83 (2003) 1166-1168
11. Emami S., Le Floch N., Bruyneel E., Thim L., May F.E.B., Westley B., et al. Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells. FASEB J 15 (2001) 351-361
12. Foekens J.A., Portengen H., Look M.P., van Putten W.L., Thirion B., Bontenbal M., et al. Relationship of PS2 with response to tamoxifen therapy in patients with recurrent breast cancer. Br J Cancer 70 (1994) 1217-1223
13. Fujimoto J., Yasui W., Tahara H., Tahara E., Kudo Y., Yokozaki H., et al. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis. Cancer Lett 149 (2000) 125-134
14. Henry J.A., Bennett M.K., Piggott N.H., Levett D.L., May F.E.B., and Westley B.R. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours. Br J Cancer 64 (1991) 677-682
15. Lefebvre O., Chenard M.P., Masson R., Linares J., Dierich A., LeMeur M., et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 274 (1996) 259-262
16. Lemercinier X., Muskett F.W., Cheeseman B., McIntosh P.B., Thim L., and Carr M.D. High-resolution solution structure of human intestinal trefoil factor and functional insights from detailed structural comparisons with the other members of the trefoil family of mammalian cell motility factors. Biochemistry 40 (2001) 9552-9559
17. Madsen J., Nielsen O., Tornoe I., Thim L., and Holmskov U. Tissue localization of human trefoil factors 1, 2 and 3. J Histochem Cytochem 55 (2007) 505-513
18. Marchbank T., Westley B.R., May F.E.B., Calnan D.P., and Playford R.J. Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects. J Pathol 185 (1998) 153-158
19. Martin T.E., Powell C.T., Wang Z., Bhattacharyya S., Walsh-Reitz M.M., Agarwal K., et al. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Am J Physiol Gastrointest Liver Physiol 285 (2003) G332-343
20. Masiakowski P., Breathnach R., Bloch J., Gannon F., Krust A., and Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res 10 (1982) 7895-7903
21. May F.E.B., and Westley B.R. Cloning of estrogen-regulated messenger RNA sequences from human breast cancer cells. Cancer Res 46 (1986) 6034-6040
22. May F.E.B., and Westley B.R. Trefoil proteins: their role in normal and malignant cells. J Pathol 183 (1997) 4-7
23. May F.E.B., Church S.T., Major S., and Westley B.R. The closely related estrogen-regulated trefoil proteins TFF1 and TFF3 have markedly different hydrodynamic properties, overall charge, and distribution of surface charge. Biochemistry 42 (2003) 8250-8259
24. May F.E.B., Semple J.I., Newton J.L., and Westley B.R. The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach. Gut 46 (2000) 454-459
25. May F.E.B., Semple J.I., Prest S.J., and Westley B.R. Expression and motogenic activity of TFF2 in human breast cancer cells. Peptides 25 (2004) 865-872
26. Mikhitarian K., Gillanders W.E., Almeida J.S., Hebert Martin R., Varela J.C., Metcalf J.S., et al. An innovative microarray strategy identities informative molecular markers for the detection of micrometastatic breast cancer. Clin Cancer Res 11 (2005) 3697-3704
27. Muller W., and Borchard F. pS2 protein in gastric carcinoma and normal gastric mucosa: association with clincopathological parameters and patient survival. J Pathol 171 (1993) 263-269
28. Nardone G., Rippa E., Martin G., Rocco A., Siciliano R.A., Fiengo A., et al. Gastrokine 1 expression in patients with and without Helicobacter pylori infection. Dig Liver Dis 39 (2007) 122-129
29. Newton J.L., Allen A., Westley B.R., and May F.E.B. The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. Gut 46 (2000) 312-320
30. Oien K.A., McGregor F., Butler S., Ferrier R.K., Downie I., Bryce S., et al. Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation. J Pathol 203 (2004) 789-797
31. Otto W.R., Patel K., McKinnell I., Evans M.D., Lee C.Y., Frith D., et al. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Proteomics 6 (2006) 4235-4245
32. Park W.S., Oh R.R., Park J.Y., Lee J.H., Shin M.S., Kim H.S., et al. Somatic mutations of the trefoil factor family 1 gene in gastric cancer. Gastroenterology 119 (2000) 691-698
33. Park W.S., Oh R.R., Park J.Y., Yoo N.J., Lee S.H., Shin M.S., et al. Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers. Cancer Lett 159 (2000) 15-21
34. Piggott N.H., Henry J.A., May F.E.B., and Westley B.R. Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. J Pathol 163 (1991) 95-104
35. Playford R.J., Marchbank T., Goodlad R.A., Chinery R.A., Poulsom R., and Hanby A.M. Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage. Proc Natl Acad Sci USA 93 (1996) 2137-2142
36. Polshakov V.I., Williams M.A., Gargaro A.R., Frenkiel T.A., Westley B.R., Chadwick M.P., et al. High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein. J Mol Biol 267 (1997) 418-432
37. Prest S.J., May F.E.B., and Westley B.R. The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells. FASEB J 16 (2002) 592-594
38. Pu M., May F.E.B., Playford R.J., Ruchaud-Sparagano M.H., and Westley B.R. Development of a two-site ELISA assay for the dimeric form of human TFF1. Peptides 25 (2004) 731-736
39. Resnick M.B., Sabo E., Meitner P.A., Kim S.S., Cho Y., Kim H.K., et al. Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo. Gut 55 (2006) 1717-1724
40. Ribieras S., Tomasetto C., and Rio M.C. The pS2/TFF1 trefoil factor, from basic research to clinical applications. Biochim Biophys Acta 1378 (1998) F61-77
41. Rio M.C., Bellocq J.P., Daniel J.Y., Tomasetto C., Lathe R., Chenard M.P., et al. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Science 241 (1988) 705-708
42. Rio M.C., Bellocq J.P., Gairard B., Rasmussen U.B., Krust A., Koehl C., et al. Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. Proc Natl Acad Sci USA 84 (1987) 9243-9247
43. Rodrigues S., Van Aken E., Van Bocxlaer S., Attoub S., Nguyen Q.D., Bruyneel E., et al. Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signalling. FASEB J 17 (2003) 7-16
44. Ruchaud-Sparagano M.H., Westley B.R., and May F.E.B. The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa. Cell Mol Life Sci 61 (2004) 1946-1954
45. Sanchez-Pulido L., Devos D., and Valencia A. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem Sci 27 (2002) 329-332
46. Smid M., Wang Y., Klijn J.G., Sieuwerts A.M., Zhang Y., Atkins D., et al. Genes associated with breast cancer metastatic to bone. J Clin Oncol 24 (2006) 2261-2267
47. Thim L., Madsen F., and Poulsen S.S. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest 32 (2002) 519-527
48. Toback F.G., Walsh-Reitz M.M., Musch M.W., Chang E.B., Del Valle J., Ren H., et al. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol 285 (2003) G344-353
49. Tomasetto C., Masson R., Linares J.L., Wendling C., Lefebvre O., Chenard M.P., et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology 118 (2000) 70-80
50. Westley B.R., Griffin S.M., and May F.E.B. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 44 (2005) 7967-7975
51. Williams M.A., Westley B.R., May F.E.B., and Feeney J. The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF1. FEBS Lett 493 (2001) 70-74
52. Yoshikawa Y., Mukai H., Hino F., Asada K., and Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res 91 (2000) 459-463