Intestinal trefoil factor: A marker of poor prognosis in gastric carcinoma

Clinical Cancer Research

Volumn 8, Issue 5, 2002, Pages 1092-1099

  Yamachika, Takasuke ^a   Werther, J Lawrence ^a   Bodian, Carol ^b   Babyatsky, Mark ^a   Tatematsu, Masae ^c   Yamamura, Yoshitaka ^d   Chen, Anli ^a   Itzkowitz, Steven ^a  

^a Vet Affairs Healthcare Connecticut   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Laboratory of Pathology   (Japan)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTESTINAL TREFOIL FACTOR;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER INFILTRATION; CANCER STAGING; CELL ADHESION; CELL DIFFERENTIATION; CELL INVASION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CARCINOMA; SURVIVAL RATE;

ADENOCARCINOMA; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; FEMALE; GASTRIC MUCOSA; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUCINS; MUSCLE PROTEINS; NEOPLASM STAGING; NEUROPEPTIDES; PEPTIDES; PROGNOSIS; SEX FACTORS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0036094237     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. A new family of growth factor-like peptides: "Trefoil" disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins)
2. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3
3. Trefoil family domain peptides
4. Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa
5. Spasmolytic polypeptide: A trefoil peptide secreted by gastric mucous cells
6. Trefoil peptides: Mitogens, motogens, or mirages?
7. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease
8. Identification of human intestinal trefoil factor: Goblet cell-specific expression of a peptide targeted for apical secretion
9. hP1 B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus
10. Intestinal trefoil factor (TFF3) and pS2 but not spasmolytic polypeptide are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium
11. Co-localization of TFF3 peptide and oxytocin in the human hypothalamus
12. Trefoil factor expression in normal and diseased human salivary glands
13. Trefoil factor family domain peptides in the human respiratory tract
14. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues
15. Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein
16. Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats
17. Trefoil peptides promote epithelial migration through a transforming growth factor β-independent pathway
18. Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor, and transforming growth factor α mRNAs in rat stomach
19. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
20. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell lines
21. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours
22. Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma
23. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
24. Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers
25. Breast cancer-associated protein pS2 expression in tumor of biliary tract
26. Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma
27. Expression of human intestinal trefoil factor in malignant cells and its regulation by oestrogen in breast cancer cells
28. Primary mucinous carcinomas of skin express TFF1, TFF3, estrogen receptor, and progesterone receptors
29. Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence
30. Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinomas
31. Molecular aspects of restitution: Functions of trefoil peptides
32. Rolling in the clover: Trefoil factor family (TFF)-domain peptides, cell migration and cancer
33. Phosphorylation of β-catenin and epidermal growth factor receptor by intestinal trefoil factor
34. Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells
35. Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells
36. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
37. Transcription factor NF-kB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells
38. Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFFI) expression precedes metaplastic differentiation of gastric epithelium
39. Cancer Statistics, 2001
40. Localization of estrogen receptors in gastric cancer using immunohistochemical staining of monoclonal antibody
41. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes
42. Characterization of four main cell types in gastric cancers: Foveolar, mucopeptic, intestinal columnar and goblet cells. An histopathologic, histochemical and ultrastructural study of "early" and "advanced" tumors
43. Proliferative markers in gastric carcinoma and organoid differentiation
44. Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry
45. Histogenesis of human stomach cancers based on assessment of differentiation
46. The two histological main types of gastric carcinomas: Diffuse and so called intestinal-type carcinoma, An attempt at a histoclinical classification
47. Pathological studies of human gastric cancer
48. Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression
49. Intestinalization of gastric signet ring cell carcinomas with progression
50. pS2 protein expression in gastric carcinoma. An immunohistochemical and immunoradiometric study
51. Expression of pepsinogen II in gastric cancer. Its relationship to local invasion and lymph node metastases