All-trans retinoic acid inhibits tumor growth of human osteosarcoma by activating Smad signaling-induced osteogenic differentiation

International Journal of Oncology

Volumn 41, Issue 1, 2012, Pages 153-160

  Yang, Qiu Jun ^a   Zhou, Long Yang ^a   Mu, Yu Qin ^a   Zhou, Qi Xin ^a   Luo, Jin Yong ^a   Cheng, Lang ^a   Deng, Zhong Liang ^a   He, Tong Chuan ^a,b   Haydon, Rex C ^b   He, Bai Cheng ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

All trans retinoic acid; Osteogenic differentiation; Osteosarcoma; Proliferation inhibition; Smad signaling

Indexed keywords

ALKALINE PHOSPHATASE; BETA ACTIN; BIOLOGICAL MARKER; CASPASE 3; OSTEOCALCIN; OSTEOPONTIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR; SMAD PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; NUDE MOUSE; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROGNOSIS; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, DIFFERENTIATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FIBROBLASTS; GENES, REPORTER; HUMANS; LUCIFERASES, FIREFLY; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OSTEOGENESIS; OSTEOSARCOMA; PHOSPHORYLATION; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTOR ALPHA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRETINOIN;

EID: 84862867348     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1426     Document Type: Article

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