A caspase 8-based suicide switch induces apoptosis in nanobody-directed chimeric receptor expressing T cells

International Journal of Hematology

Volumn 95, Issue 4, 2012, Pages 434-444

  Khaleghi, Sepideh ^a   Ahmadvand, Davoud ^b   Pognonec, Philippe ^c   Rahbarizadeh, Fatemeh ^a   Rasaee, Mohammad J ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

Apoptosis; Chimeric receptor; Co stimulatory signal; Nanobody; OX40

Indexed keywords

ANTIBODY; CASPASE 8; CD134 ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CELL SURFACE RECEPTOR; CHIMERIC PROTEIN; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 2; LIPOCORTIN 5; MESSENGER RNA; MUCIN 1; NANOBODY; PHOSPHATIDYLSERINE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUICIDE GENE; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MUCIN-1; NIH 3T3 CELLS; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; T-LYMPHOCYTES; TRANSFECTION;

EID: 84862859378     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-012-1037-6     Document Type: Article

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