Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers

International Journal of Pharmaceutics

Volumn 433, Issue 1-2, 2012, Pages 89-93

  Chen, Gong ^a   Yang, Lin ^a   Zhang, Hu ^a   Tucker, Ian G ^a   Fawcett, J Paul ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Caco 2 cells; Cytotoxicity; Ketocholate derivatives; Membrane fluidity; Methotrexate

Indexed keywords

12 MONOKETOCHOLATE; 3,7 DIKETOCHOLATE; CHOLIC ACID DERIVATIVE; HYDROXYL GROUP; LACTATE DEHYDROGENASE; METHOTREXATE; TRIKETOCHOLATE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE FLUIDITY; CELL STRAIN CACO 2; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG FORMULATION; DRUG INHIBITION; DRUG PENETRATION; DRUG UPTAKE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; CACO-2 CELLS; CHOLATES; CHROMATOGRAPHY, LIQUID; EXCIPIENTS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE FLUIDITY; METHOTREXATE; MICELLES; PERMEABILITY; TANDEM MASS SPECTROMETRY;

EID: 84862855318     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.077     Document Type: Article

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