Pigment epithelium-derived factor released by mü ller glial cells exerts neuroprotective effects on retinal ganglion cells

Neurochemical Research

Volumn 37, Issue 7, 2012, Pages 1524-1533

  Unterlauft, Jan Darius ^a   Eichler, Wolfram ^a   Kuhne, Konstantin ^a   Mei Yang, Xiu ^a   Yafai, Yousef ^a   Wiedemann, Peter ^a   Reichenbach, Andreas ^a   Claudepierre, Thomas ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Neuron glia interaction Reactive glia; Neuroprotection; Neuroregeneration

Indexed keywords

PIGMENT EPITHELIUM DERIVED FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL SURVIVAL; COCULTURE; HYPOXIA; IN VITRO STUDY; MOUSE; MUELLER CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; RETINA GANGLION CELL;

ANIMALS; BASE SEQUENCE; COCULTURE TECHNIQUES; DNA PRIMERS; EYE PROTEINS; MICE; MICE, INBRED BALB C; NERVE GROWTH FACTORS; NEUROGLIA; NEUROPROTECTIVE AGENTS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL GANGLION CELLS; SERPINS;

EID: 84862854536     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0747-8     Document Type: Article

References (56)

1. Kawaguchi T, Yamagishi SI, Sata M (2010) Structure-function relationships of PEDF. Curr Mol Med 10:302-311
2. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP (1999) Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285:245-248
3. Doll JA, Stellmach VM, Bouck NP, Bergh AR, Lee C, Abramson LP, Cornwell ML, Pins MR, Borensztajn J, Crawford SE (2003) Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med 9:774-780
4. Steele FR, Chader GJ, Johnson LV, Tombran-Tink J (1993) Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci U S A 90:1526-1530
5. Eichler W, Yafai Y, Wiedemann P, Reichenbach A (2004) Angiogenesis-related factors derived from glial Müller cells in hypoxia. NeuroReport 15:1633-1637
6. Eichler W, Yafai Y, Keller T, Wiedemann P, Reichenbach A (2004) PEDF derived from glial Mü ller cells: a possible regulator of retinal angiogenesis. Exp Cell Res 299:68-78
7. Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Mori K, Katai M, Yan L, Suzuma K, West K, Davarya S, Tong P, Gehlbach P, Pearlman J, Crabb JW, Aiello LP, Campochiaro PA (2002) Pigment epithelium-derived factor suppresses ischemiainduced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci 43:821-829
8. Yang XM, Yafai Y, Wiedemann P, Kuhrt H, Wang YS, Reichenbach A, Eichler W (2012) Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (Müller) cells. J Neurosci Res 90:257-266
9. Yafai Y, Lange J, Wiedemann P, Reichenbach A, Eichler W (2007) Pigment epithelium-derived factor acts as an opponent of growth-stimulatory factors in retinal glial-endothelial cell interactions. Glia 55:642-651
10. Lange J, Yafai Y, Reichenbach A, Wiedemann P, Eichler W (2008) Regulation of pigment epithelium-derived factor production and release by retinal glial (Müller) cells under hypoxia. Invest Ophthalmol Vis Sci 49:5161-5167
11. Tsao YP, Ho TC, Chen SL, Cheng HC (2006) Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells. Life Sci 79:545-550
12. Zhang SX, Wang JJ, Gao G, Shao C, Mott R, Ma JX (2006) Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB J 20:323-325
13. Park K, Jin J, Hu Y, Zhou K, Ma JX (2011) Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. Am J Pathol 178:688-698
14. Murugeswari P, Shukla D, Rajendran A, Kim R, Namperumalsamy P, Muthukkaruppan V (2008) Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. Retina 28:817-824
15. Araki T, Taniwaki T, Becerra SP, Chader GJ, Schwartz JP (1998) Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res 53:7-15
16. Houenou LJ, D'Costa AP, Li L, Turgeon VL, Enyadike C, Alberdi E, Becerra SP (1999) Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. J Comp Neurol 412:506-514
17. Pang IH, Zeng H, Fleenor DL, Clark AF (2007) Pigment epithelium-derived factor protects retinal ganglion cells. BMC Neurosci 8:11
18. Cao W, Tombran-Tink J, Chen W, Mrazek D, Elias R, McGinnis JF (1999) Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J Neurosci Res 57:789-800
19. Cao W, Tombran-Tink J, Elias R, Sezate S, Mrazek D, McGinnis JF (2001) In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 42:1646-1652
20. Cayouette M, Smith SB, Becerra SP, Gravel C (1999) Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6:523-532
21. Takita H, Yoneya S, Gehlbach PL, Duh EJ, Wei LL, Mori K (2003) Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 44:4497-4504
22. Zhou X, Li F, Kong L, Chodosh J, Cao W (2009) Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2 J mice. Mol Vis 15:438-450
23. John SW, Smith RS, Savinova OV, Hawes NL, Chang B, Turnbull D, Davisson M, Roderick TH, Heckenlively JR (1998) Essential iris atrophy, pigment dispersion, and glaucoma in DBA/ 2 J mice. Invest Ophthalmol Vis Sci 39:951-962
24. Schuettauf F, Quinto K, Naskar R, Zurakowski D (2002) Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2 J mouse model. Vision Res 42:2333-2337
25. Quigley HA, Broman AT (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 90:262-267
26. Levin LA (2003) Retinal ganglion cells and neuroprotection for glaucoma. Surv Ophthalmol 48:S21-S24
27. Aymerich MS, Alberdi EM, Mart?́nez A, Becerra SP (2001) Evidence for pigment epithelium-derived factor receptors in the neural retina. Invest Ophthalmol Vis Sci 42:3287-3293
28. Notari L, Baladron V, Aroca-Aguilar JD, Balko N, Heredia R, Meyer C, Notario PM, Saravanamuthu S, Nueda ML, Sanchez-Sanchez F, Escribano J, Laborda J, Becerra SP (2006) Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem 281:38022-38037
29. Miyazaki M, Ikeda Y, Yonemitsu Y, Goto Y, Murakami Y, Yoshida N, Tabata T, Hasegawa M, Tobimatsu S, Sueishi K, Ishibashi T (2011) Pigment epithelium-derived factor gene therapy targeting retinal ganglion cell injuries: neuroprotection against loss of function in two animal models. Hum Gene Ther 22:559-565
30. Ogata N,Wang L, Jo N, Tombran-Tink J, Takahashi K, Mrazek D, Matsumura M (2001) Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury. Curr Eye Res 22:245-252
31. Li H, Tran VV, Hu Y, Mark Saltzman W, Barnstable CJ, Tombran-Tink J (2006) A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Exp Eye Res 83:824-833
32. El Sanharawi M, Kowalczuk L, Touchard E, Omri S, de Kozak Y, Behar-Cohen F (2010) Protein delivery for retinal diseases: from basic considerations to clinical applications. Prog Retin Eye Res 29:443-465
33. Amaral J, Fariss RN, Campos MM, Robison WG Jr, Kim H, Lutz R, Becerra SP (2005) Transscleral-RPE permeability of PEDF and ovalbumin proteins: implications for subconjunctival protein delivery. Invest Ophthalmol Vis Sci 46:4383-4392
34. Stitt AW, Graham D, Gardiner TA (2004) Ocular wounding prevents pre-retinal neovascularization and upregulates PEDF expression in the inner retina. Mol Vis 10:432-438
35. Steinmetz CC, Buard I, Claudepierre T, Nägler K, Pfrieger FW (2006) Regional variations in the glial influence on synapse development in the mouse CNS. J Physiol 577:249-261
36. Claudepierre T, Koncina E, Pfrieger FW, Bagnard D, Aunis D, Reber M (2008) Implication of neuropilin 2/semaphorin 3F in retinocollicular map formation. Dev Dyn 237:3394-3403
37. Thumann G, Hueber A, Dinslage S, Schaefer F, Yasukawa T, Kirchhof B, Yafai Y, Eichler W, Bringmann A, Wiedemann P (2006) Characteristics of iris and retinal pigment epithelial cells cultured on collagen type I membranes. Curr Eye Res 31: 241-249
38. Eibl KH, Schwabe K, Welge-Luessen U, Kampik A, Eichler W (2008) The role of alkylphosphocholines in retinal Mü ller glial cell proliferation. Curr Eye Res 33:385-393
39. Becerra SP, Fariss RN, Wu YQ, Montuenga LM, Wong P, Pfeffer BA (2004) Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution. Exp Eye Res 78:223-234
40. Danesh-Meyer HV (2011) Neuroprotection in glaucoma: recent and future directions. Curr Opin Ophthalmol 22:78-86
41. Taniwaki T, Becerra SP, Chader GJ, Schwartz JP (1995) Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture. J Neurochem 64:2509-2517
42. Barnstable CJ, Tombran-Tink J (2004) Neuroprorective and antiangiogenic activity of PEDF in the eye: molecular targets and therapeutic potential. Prog Ret Res 23:561-577
43. Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, Osborne NN, Reichenbach A (2006) Mü ller cells in the healthy and diseased retina. Prog Retin Eye Res 25:397-424
44. Bringmann A, Iandiev I, Pannicke T, Wurm A, Hollborn M, Wiedemann P, Osborne NN, Reichenbach A (2009) Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res 28: 423-451
45. DawsonDW,VolpertOV,Gillis P,CrawfordSE,Xu H,BenedictW, Bouck NP (1999) Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285:245-248
46. Gao GQ, Li Y, Zhang DC, Gee S, Crosson C, Ma JX (2001) Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett 489:270-276
47. Notari L, Miller A, Mart?́nez A, Amaral J, Ju M, Robinson G, Smith LE, Becerra SP (2005) Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci 46:2736-2747
48. Tuccari G, Trombetta C, Giardinelli MM, Arena F, Barresi G (1986) Distribution of glial fibrillary acidic protein in normal and gliotic human retina. Basic Appl Histochem 30:425-432
49. Wurm A, Iandiev I, Uhlmann S, Wiedemann P, Reichenbach A, Bringmann A, Pannicke T (2011) Effects of ischemia-reperfusion on physiological properties of Müller glial cells in the porcine retina. Invest Ophthalmol Vis Sci 52:3360-3367
50. Frasson M, Picaud S, Léveillard T, Simonutti M, Mohand-Said S, Dreyfus H, Hicks D, Sabel J (1999) Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci 40:2724-2734
51. Oku H, Ikeda T, Honma Y, Sotozono C, Nishida K, Nakamura Y, Kida T, Kinoshita S (2002) Gene expression of neurotrophins and their high-affinity Trk receptors in cultured human Müller cells. Ophthalmic Res 34:38-42
52. Fischer AJ, Schmidt M, Omar G, Reh TA (2004) BMP4 and CNTF are neuroprotective and suppress damage-induced proliferation of Müller glia in the retina. Mol Cell Neurosci 27:531-542
53. Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A (2001) Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. Glia 35:14-25
54. Shen X, Zhong Y, Xie B, Cheng Y, Jiao Q (2010) Pigment epithelium derived factor as an anti-inflammatory factor against decrease of glutamine synthetase expression in retinal Müller cells under high glucose conditions. Graefe's Arch Clin Exp Ophthalmol 248:1127-1136
55. Sweigard JH, Cashman SM, Kumar-Singh R (2009) Adenovirus vectors targeting distinct cell types in the retina. Invest Ophthalmol Vis Sci 51:2219-2228
56. Bull ND, Limb GA, Martin KR (2008) Human Mü ller stem cell (MIO-M1) transplantation in a rat model of glaucoma: survival, differentiation, and integration. Invest Ophthalmol Vis Sci 49:3449-3456