The structural basis for serotype-specific neutralization of dengue virus by a human antibody

Science Translational Medicine

Volumn 4, Issue 139, 2012, Pages

  Teoh, Ee Ping ^a   Kukkaro, Petra ^a,b   Teo, En Wei ^a   Lim, Angeline P C ^b   Tan, Tze Tong ^a   Yip, Andy ^c   Schul, Wouter ^c   Aung, Myint ^a,b   Kostyuchenko, Victor A ^a,b   Leo, Yee Sin ^d   Chan, Soh Ha ^a   Smith, Kenneth G C ^e   Chan, Annie Hoi Yi ^f   Zou, Gang ^c   Ooi, Eng Eong ^b   Kemeny, D Michael ^a   Tan, Grace K ^a   Ng, Jowin K W ^a   Ng, Mah Lee ^a   Alonso, Sylvie ^a   Fisher, Dale ^g   Shi, Pei Yong ^c   Hanson, Brendon J ^f   Lok, Shee Mei ^a,b   MacAry, Paul A ^a   more..

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^d TAN TOCK SENG HOSPITAL   (Singapore)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f DSO NATIONAL LABORATORIES   (Singapore)

^g NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; EPITOPE; FC RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; RECOMBINANT HUMAN ANTIBODY 14C10; UNCLASSIFIED DRUG; VIRUS ANTIBODY; ANTIVIRUS AGENT; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DENGUE; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 4; DRUG EFFICACY; DRUG POTENCY; HUMAN; IN VIVO STUDY; MOLECULAR INTERACTION; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; SEROTYPE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PROPERTY; VIRUS ATTACHMENT; VIRUS IMMUNITY; VIRUS NEUTRALIZATION; ANIMAL; DRUG EFFECT; IMMUNOLOGY; ULTRASTRUCTURE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIVIRAL AGENTS; CRYOELECTRON MICROSCOPY; DENGUE; DENGUE VIRUS; EPITOPES; HUMANS; MICE;

EID: 84862850400     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003888     Document Type: Article

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