Encapsulation of azithromycin into polymeric microspheres by reduced pressure-solvent evaporation method

International Journal of Pharmaceutics

Volumn 433, Issue 1-2, 2012, Pages 79-88

  Li, Xiujuan ^a   Chang, Si ^a   Du, Guangsheng ^a   Li, Yi ^a   Gong, Junbo ^a   Yang, Mingshi ^b   Wei, Zhenping ^a  

^a TIANJIN UNIVERSITY   (China)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antoine equation; Azithromycin; Burst release; Crystallinity; Reduced pressure solvent evaporation

Indexed keywords

AZITHROMYCIN; MICROSPHERE; POLYGLACTIN; POLYLACTIDE;

ARTICLE; ATMOSPHERE; ATMOSPHERE SOLVENT EVAPORATION; CONTROLLED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; ENCAPSULATION; EVAPORATION; KINETICS; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRESSURE SOLVENT EVAPORATION; PRIORITY JOURNAL; SOLIDIFICATION TIME; TEMPERATURE; TIME; X RAY POWDER DIFFRACTION;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; KINETICS; LACTIC ACID; MICROSPHERES; POLYESTERS; POLYGLYCOLIC ACID; POROSITY; SOLVENTS; TEMPERATURE; TIME FACTORS; X-RAY DIFFRACTION;

EID: 84862849500     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.081     Document Type: Article

References (34)

1. Angadi, S.C., Manjeshwar, L.S., Aminabhavi, T.M., 2011. Stearic acid-coated chitosanbased polymer network microspheres: controlled release characteristics. Ind. Eng. Chem. Res. 50, 4504-4514.
2. Ballow, C.H., Amsden, G.W., 1992. Azithromycin: the first azalide antibiotic. Ann. Pharmacother. 26, 1253-1261.
3. Berkland, C., King, M., Cox, A., Kim, K.K., Pack, D.W., 2002. Precise control of PLG microsphere size provides enhanced control of drug release rate. J. Control. Release 82, 137-147. (Pubitemid 34775055)
4. Chaturvedi, K., Kulkarni, A.R., Aminabhavi, T.M., 2011. Blend microspheres of poly(3-hydroxybutyrate) and cellulose acetate phthalate for colon delivery of 5-fluorouracil. Ind. Eng. Chem. Res. 50, 10414-10423.
5. Chung, T.W., Huang, Y.Y., Liu, Y.Z., 2001. Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres. Int. J. Pharm. 212, 161-169.
6. Freiberg, S., Zhu, X.X., 2004. Polymer microspheres for controlled drug release. Int. J. Pharm. 282, 1-18. (Pubitemid 39178480)
7. Freytag, T., Dashevsky, A., Tillman, L., Hardee, G.E., Bodmeier, R., 2000. Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres. J. Control. Release 69, 197-207.
8. Gao, Y., Cui, F.D., Guan, Y., Yang, L., Wang, Y.S., Zhang, L.N., 2006. Preparation of roxithromycin-polymeric microspheres by the emulsion solvent diffusion method for taste masking. Int. J. Pharm. 318, 62-69. (Pubitemid 43983049)
9. Girard, A.E., Girard, D., English, A.R., Gootz, T.D., Cimochowski, C.R., Faiella, J.A., Haskell, S.L., Retsema, J.A., 1987. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993) a new macrolide with an extend half-life and excellent tissue distribution. Antimicrob. Agents Chemother. 31, 1948-1954. (Pubitemid 18009567)
10. Hagen, T., Lo, J.B., Thombre, A., Herbig, S., Appel, L., Crew, M., 2005. Azithromycin dosage forms with reduced side effects. Patent No.: EP1, 537, 859B1.
11. He, J.T., Su, H.B., Li, G.P., Tao, X.M., Mo, W., Song, H.Y., 2006. Stabilization and encapsulation of a staphylokinase variant (K35R) into poly(lactic-co-glycolide acid) microspheres. Int. J. Pharm. 309, 101-108. (Pubitemid 43129471)
12. Igartua, M., Hernandez, R.M., Rosas, J.E., Patarroyo, M.E., Pedraz, J.L., 2008. Gamma- Irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine. Eur. J. Pharm. Biopharm. 69 (2), 519-526.
13. Izumikawa, S., Yoshioka, S., Aso, Y., Takeda, Y., 1991. Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate. J. Control. Release 15, 133-140.
14. Jeyanthi, R., Mehta, R.C., Thanoo, B.C., Deluca, P.P., 1996. Effects of solvent removal technique on the matrix characteristics of polylactide: glycolide microspheres for peptide delivery. J. Control. Release 38, 235-244. (Pubitemid 26098644)
15. Li, M., Rouaud, O., Poncelet, D., 2008. Microencapsulation by solvent evaporation: state of the art for process engineering approaches. Int. J. Pharm. 363, 26-39.
16. Lin, W.J., Yu, C.C., 2002. The effect of solvent removal conditions on performance and release property of protein-loaded microparticles. J. Microencapsulation 19, 767-773.
17. Liu, R., Huang, S.S., Wan, Y.H., Ma, G.H., Su, Z.G., 2006. Preparation of insulin-loaded PLA/PLGA microcapsules by a novel membrane emulsification method and its release in vitro. Colloids Surf. B: Biointerface 51, 30-38. (Pubitemid 44094033)
18. Matsumoto, A., Matsukawa, Y., Suzuki, T., Yoshino, H., Kobayashi, M., 1997. The polymer-alloys method as a new preparation method of biodegradable microspheres: principle and application to cisplatin loaded microspheres. J. Control. Release 48, 19-27. (Pubitemid 27304391)
19. Meng, F.T., Ma, G.H., Liu, Y.D., Qiu, W., Su, Z.G., 2004. Microencapsulation of bovine hemoglobin with high bio-activity and high entrapment efficiency using a W/O/W double emulsion technique. Colloids. Surf. B: Biointerface 33, 177-183. (Pubitemid 38183003)
20. Miyazaki, Y., Onuki, Y., Yakou, S., Takayama, K., 2006. Effect of temperature-increase rate on drug release characteristics of dextran microspheres prepared by emulsion solvent evaporation process. Int. J. Pharm. 324, 144-151. (Pubitemid 44528912)
21. Mohammadi, G., Valizadeh, H., Mohammad, B.J., Lotfipour, F., Adibkia, K., Milani, M., Azhdarzadeh, M., Kiafar, F., Nokhodchi, A., 2010. Development of azithromycin- PLGA nanoparticles: physicochemical characterization and antibacterial effect against Salmonella typhi. Colloids Surf. B: Biointerface 80, 34-39.
22. Moore, J.W., Flanner, H.H., 1996. Mathematical comparison of curves with an emphasis on in vitro dissolution profiles. Pharm. Technol. 20, 64-74. (Pubitemid 126450495)
23. Mundargi, R.C., Babu, V.R., Rangaswamy, V., Pradip, P., Aminabhavi, T.M., 2008. Nano/micro technologies for delivering macromolecular therapeutics using poly(d,l-lactide-co-glycolide) and its derivatives. J. Control. Release 125, 193-209.
24. National Institute of Standards and Technology (NIST), 2011. http://webbook.nist.gov/cgi/cbook.cgi?ID=C75092&Units=SI&Mask= 4#Thermophase (accessed 08.10.11).
25. Oh, Y.J., Lee, J., Seo, J.Y., Rhim, T., Kim, S.H., Yoon, H.J., Lee, K.Y., 2011. Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model. J. Control. Release 150, 56-62.
26. Pekarek, K.J., Dyrud, M.J., Ferrer, K., Jong, Y.S., Mathiowitz, E., 1996. In vitro and in vivo degradation of double-walled polymer microspheres. J. Control. Release 40, 169-178. (Pubitemid 26238369)
27. Pollauf, E.J., Pack, D.W., 2006. Use of thermodynamic parameters for design of double-walled microsphere fabrication methods. Biomaterials 27, 2898-2906. (Pubitemid 43165759)
28. Shah, V.P., Tsong, Y., Sathe, P., Liu, J.P., 1998. In vitro dissolution profile comparisonstatistics and analysis of the similarity factor, f2. Pharm. Res. 15, 889-896. (Pubitemid 28307831)
29. Sultana, N., Arayne, M.S., Hussain, F., Fatima, A.F., 2006. Degradation studies of Azithromycin and its spectrophotometric determination in pharmaceutical dosage forms. Pak. J. Pharm. Sci. 19, 98-103.
30. Tan, E.C., Lin, R., Wang, C.H., 2005. Fabrication of double-walled microspheres for the sustained release of doxorubicin. J. Colloid Interface Sci. 291, 135-143. (Pubitemid 41392917)
31. Tan, H.X., Ye, J.D., 2008. Surface morphology and in vitro release performance of double-walled PLLA/PLGA microspheres entrapping a highly water-soluble drug. Appl. Surf. Sci. 255, 353-356.
32. William, C., 2011. Interdisciplinary science and the design of a single-dose antibiotic therapy. Pharm. Res. 28 (9), 2059-2071.
33. Yang, Y.Y., Chung, T.S., Bai, X.L., Chan, W.K., 2000. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method. Chem. Eng. Sci. 55, 2223-2236.
34. Ye, M.L., Kim, S.W., Park, K., 2010. Issues in long-term protein delivery using biodegradable microparticles. J. Control. Release 146, 241-260.