In vitro and in vivo degradation of double-walled polymer microspheres

Journal of Controlled Release

Volumn 40, Issue 3, 1996, Pages 169-178

  Pekarek, Kathleen J ^a   Dyrud, Martinus J ^a   Ferrer, Kathy ^a   Jong, Yong S ^a   Mathiowitz, Edith ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Controlled release; Degradation, in vitro; Degradation, in vivo; Double walled microsphere; Solvent evaporation

Indexed keywords

MICROSPHERE; POLYANHYDRIDE; POLYLACTIC ACID; POLYMER;

ANIMAL MODEL; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG IMPLANTATION; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MICROENCAPSULATION; NONHUMAN; PHARMACEUTICS; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE PREPARATION;

EID: 0029938435     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00176-X     Document Type: Article

References (7)

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4. E. Domb and R. Langer, Polyanhydrides. I. Preparation of high molecular weight polyanhydrides, J. Polym. Sci. 25 (1987) 3373-3386.
5. E. Domb, E. Mathiowitz, E. Ron, S. Giannos and R. Langer, Polyanhydrides. IV. Unsaturated polymers composed of fumaric acid, J. Polym. Sci. 29 (1991) 571-79.
6. E. Mathiowitz, M.R. Kreitz and K.J. Pekarek, Morphological characterization of bioerodible polymers. 2. Characterization of polyanhydrides by fourier-transform infrared spectroscopy, Macromolecules 26 (1993) 6749-6755.
7. E. Mathiowitz, J.S. Jacob, K.J. Pekarek and D.C. Chickering III, Morphological characterization of bioerodible polymers. 3. Charcterization of the erosion and intact zones in polyanhydrides using scanning electron microscopy, Macromolecules 26 (1993) 6756-6765.