Synthesis and structure-activity relationship studies of hiv-1 virion infectivity factor (vif) inhibitors that block viral replication

ChemMedChem

Volumn 7, Issue 7, 2012, Pages 1217-1229

  Ali, Akbar ^a   Wang, Jinhua ^a   Nathans, Robin S ^a   Cao, Hong ^a   Sharova, Natalia ^b   Stevenson, Mario ^b   Rana, Tariq M ^a,c  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

Antiviral agents; Drug discovery; HIV 1 Vif; Inhibitors; Protein protein interactions; Structure activity relationships

Indexed keywords

2 PROPANOL; AMINE; ANTIVIRUS AGENT; BENZAMIDE DERIVATIVE; BENZOIC ACID DERIVATIVE; BORONIC ACID DERIVATIVE; COPPER COMPLEX; COPPER IODIDE; ETHANE; ETHER DERIVATIVE; ETHYLENE GLYCOL DIMETHYL ETHER; METHYL 2 MERCAPTOBENZOATE; N (2 METHOXYPHENYL) 2 [(4 NITROPHENYL)THIO]BENZAMIDE; PHENOL; POTASSIUM CARBONATE; RN 18; THIOPHENOL; UNCLASSIFIED DRUG; VIRION INFECTIVITY FACTOR INHIBITOR; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; CROSS COUPLING REACTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IRRADIATION; LINKAGE ANALYSIS; MICROWAVE RADIATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VIRION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 84862849229     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200079     Document Type: Article

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