A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations

International Journal of Pharmaceutics

Volumn 433, Issue 1-2, 2012, Pages 60-70

  Wu, Jian X ^a   Xia, Dengning ^a,b   Van Den Berg, Frans ^c   Amigo, José Manuel ^c   Rades, Thomas ^a,d   Yang, Mingshi ^a   Rantanen, Jukka ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Antisolvent crystallization; Crystal growth; Image analysis; Nucleation; Polarized light microscopy; Solid dispersion

Indexed keywords

NITRENDIPINE; PIROXICAM;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; IMAGE ANALYSIS; MICROPHOTOGRAPHY; ONLINE MONITORING; PARTICLE SIZE; PHASE TRANSITION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID STATE;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, POLARIZATION; NITRENDIPINE; PARTICLE SIZE; PHASE TRANSITION; PIROXICAM; SOLVENTS; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL;

EID: 84862841211     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.074     Document Type: Article

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