Real-time product morphology monitoring in crystallization using imaging technique

AIChE Journal

Volumn 51, Issue 5, 2005, Pages 1406-1414

  De Calderon Anda, J ^a   Wang, X Z ^a   Lai, X ^a   Roberts, K J ^a   Jennings, K H ^b   Wilkinson, M J ^b   Watson, D ^c   Roberts, D ^c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c MALVERN INSTRUMENTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHARACTERIZATION; CHEMICAL ENGINEERING; COOLING; CRYSTALLIZATION; CRYSTALS; DRUG PRODUCTS; IMAGING TECHNIQUES; INFILTRATION; ORGANIC CHEMICALS; REAL TIME SYSTEMS;

COOLING RATES; CRYSTAL MORPHOLOGY; PARTICLE CHARACTERIZATION; POLYMORPHS; REAL-TIME MEASUREMENT;

MORPHOLOGY;

CRYSTALLIZATION;

EID: 10644222846     PISSN: 00011541     EISSN: None     Source Type: Journal    
DOI: 10.1002/aic.10410     Document Type: Article

References (36)

1. Clydesdale G, Roberts, KJ, Docherty, R. HABIT95 - A program for predicting the morphology of molecular crystals as a function of the growth environment. J of Crystal Growth. 1996;166(1-4):78-83.
2. Walker EM, Roberts, KJ, Maginn, SJ. A molecular dynamics study of solvent and impurity interaction on the crystal habit surfaces of epsilon-caprolactam. Langmuir. 1998;14(19):5620-5630.
3. Accelrys. http://www.accelrys.com/cerius2/.
4. Liang JK. Process scale dependence of L-glutamic acid batch crystal-lised from aqueous solution in relation to reactor internals, reactant mixing and process conditions, in Department of Chemical Engineering. 2002, Heriot-Watt University, UK.
5. Gron H, Borissova A, Roberts KJ. In-process ATR-FTIR spectroscopy for closed-loop supersaturation control of a batch crystalliser producing monosodium glutamate crystals of defined size. Ind & Eng Chemistry Res. 2003;42(1): 198-206.
6. Dunuwila DD, Berglund KA. AIR FTIR spectroscopy for in situ measurement of supersaturation. J of Crystal Growth. 1997;179(1-2): 185-193.
7. Nagy ZK, Chew, JW, Fujiwara, M, Braatz, RD. Advances in the modelling and control of batch crystallizers. In ADCHEM - 7th International Symposium on Advanced Control of Chemical Processes. 2004. Hong Kong: IFAC.
8. Gron, H, Mougin, P, Thomas A, White G, Wilkinson D, Hammond RB, Lai XJ, Roberts KJ. Dynamic in-process examination of particle size and crystallographic form under defined conditions of reactant supersaturation as associated with the batch crystallization of monosodium glutamate from aqueous solution. Ind & Eng Chemistry Res. 2003;42(20):4888-4898.
9. Ono TtH JH., Jansens PJ. Quantitative measurement of the polymorphic transformation of L-glutamic acid using in-situ Raman spectroscopy. Crystal Growth & Design. 2004;4(3):465-469.
10. Ma ZH, Merkus HG, de Smet J, Heffels C, Scarlett B. New developments in particle characterization by laser diffraction: size and shape. Powder Technol.. 2000;111(1-2):66-78.
11. Mougin P, Thomas A, Wilkinson D, White G, Roberts KJ, Hermann N, Jack R, Tweedie R. On-line monitoring of a crystallization process. AIChE J. 2003;49(2):373-378.
12. Barrett P. Selecting in-process particle-size analyzers. Chem Eng Prog. 2003;99(8):26-32.
13. Yamamoto H, Matsuyama T, Wada M. Shape distinction of particulate materials by laser diffraction pattern analysis. Powder Technol. 2002; 122(2-3):205-211.
14. Ma ZH, Merkus HG, Scarlett B. Extending laser diffraction for particle shape characterization: technical aspects and application. Powder Technol. 2001;118(1-2):180-187.
15. Mougin P. In situ and on-line ultrasonic attenuation spectroscopy for particle sizing during the crystallisation of organic fine chemicals. 2001, Heriot-Watt University, UK.
16. Feng LL, Berglund KA. ATR-FTIR for determining optimal cooling curves for batch crystallization of succinic acid. Crystal Growth & Design. 2002;2(5):449-452.
17. Patience DB, Rawlings JB. Particle-shape monitoring and control in crystallization processes. AIChE J. 2001;47(9):2125-2130.
18. Barrett P, Glennon B. Characterizing the metastable zone width and solubility curve using lasentec FBRM and PVM. Chem Eng Research & Design. 2002;80(A7):799-805.
19. Patience DB. Crystal engineering through particle size and shape, monitoring, modeling and control. 2002, University of Wisconsin-Madison.
20. Kitamura M, Ishizu T. Growth kinetics and morphological change of polymorphs of L- glutamic acid. J of Crystal Growth. 2000;209(1): 138-145.
21. Davey RJ, Blagden N, Potts CD, Docherty R. Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry. J of the American Chem Soc. 1997;119(7):1767-1772.
22. Kitamura, M. Polymorphism in the Crystallization of L-Glutamic Acid. J of Crystal Growth. 1989;96(3):541-546.
23. Jackson KA. Mechanism of growth, in Liquid metals and solidification. American Society for Metals: Cleveland. 1958;174-186.
24. van der Eerden JP, Bennema P, Cherepanova T A. Survey of Monte Carlo simulations of crystal surfaces and crystal growth. Progress in Crystal Growth and Characterization. 1978;1(3):219-254.
25. Burton WK, Cabrera N, Frank FC. The growth of crystals and the equilibrium structure of their surfaces. Philosophical Transactions. 1951;A243:299-358.
26. Peterson ML, Morissette SL, McNulty C, Goldsweig A, Shaw P, LeQuesne M, Monagle J, Encina N, Marchionna J, Johnson A, Gonzalez-Zugasti J, Lemmo AV, Ellis SJ, Cima MJ, Almarsson O. Iterative high-throughput polymorphism studies on acetaminophen and an experimentally derived structure for form III. J of the American Chem Soc. 2002;124(37):10958-10959.
27. Cross WI, Blagden N, N, Davey RJ, Pritchard RG, Neumann MA, Roberts RJ, Rowe RC. A whole output strategy for polymorph screening: Combining crystal structure prediction, graph set analysis, and targeted crystallization experiments in the case of diflunisal. Crystal Growth & Design. 2003;3:151-158.
28. Hofmann DWM, Apostolakis J. Crystal structure prediction by data mining. J of Molecular Structure. 2003;647(1-3):17-39.
29. Accelrys. http://www.accelrys.com/cerius2/.
30. Winn D, Doherty MF. Modeling crystal shapes of organic materials grown from solution. AIChE J. 2000;46(7):1348-1367.
31. Wilkinson MJ, Jennings KH, Hardy M. Non-invasive video imaging for interrogating pharmaceutical crystallization processes. Microscopy and Microanalysis. 2000;6(2):996-997.
32. PVS830. http://www.malvern.co.uk.
33. Cashell C, Corcoran D, Hodnett BK. Secondary nucleation of the beta-polymorph of L-glutamic acid on the surface of alpha-form crystals. Chemical Communications. 2003(3):374-375.
34. Cashell C, Sutton D, Corcoran D, Hodnett BK. Inclusion of the stable form of a polymorph within crystals of its metastable form. Crystal Growth & Design. 2003;3(6):869-872.
35. Garti N, Zour H. The effect of surfactants on the crystallization and polymorphic transformation of glutamic acid. J of Crystal Growth. 1997;172(3-4):486-498.
36. Mougin P, Wilkinson D, Roberts KJ. In situ measurement of particle size during the crystallization of L-glutamic acid under two polymorphic forms: Influence of crystal habit on ultrasonic attenuation measurements. Crystal Growth & Design. 2002;2(3):227-234.