Polymer-mediated anti-solvent crystallization of nitrendipine: Monodispersed spherical crystals and growth mechanism

Pharmaceutical Research

Volumn 29, Issue 1, 2012, Pages 158-169

  Xia, Dengning ^a,b   Ouyang, Mei ^a   Wu, Jian X ^b   Jiang, Yanbo ^a   Piao, Hongyu ^a   Sun, Shaoping ^a,c   Zheng, Li ^a   Rantanen, Jukka ^b   Cui, Fude ^a   Yang, Mingshi ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c HEILONGJIANG UNIVERSITY   (China)

Author keywords

Amorphous; Anti solvent crystallization; Crystal growth; Nitrendipine; Spherical crystals

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; MACROGOL 200; NANOPARTICLE; NITRENDIPINE; POLOXAMER; POLYMER; POLYVINYL ALCOHOL; CALCIUM CHANNEL BLOCKING AGENT; MACROGOL DERIVATIVE; SOLVENT; WATER;

AQUEOUS SOLUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; FLOW KINETICS; LASER DIFFRACTION; MOLECULAR INTERACTION; NANOCHEMISTRY; PARTICLE SIZE; PHASE TRANSITION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; SURFACE PROPERTY; TEMPERATURE SENSITIVITY; VISCOSITY; X RAY POWDER DIFFRACTION; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; METHODOLOGY; SOLUTION AND SOLUBILITY; TEMPERATURE; X RAY DIFFRACTION;

CALCIUM CHANNEL BLOCKERS; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DRUG COMPOUNDING; MICROSCOPY, ELECTRON, SCANNING; NITRENDIPINE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYL ALCOHOL; SOLUTIONS; SOLVENTS; TEMPERATURE; WATER; X-RAY DIFFRACTION;

EID: 84860574355     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0522-6     Document Type: Article

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