Introduction to the interaction between gonadal steroids and the central nervous system

Current Topics in Behavioral Neurosciences

Volumn 8, Issue , 2011, Pages 1-13

  Marshall, Kay M ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Androgen; Mechanism of action; Oestrogen; Progesterone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANDROGEN; AROMATASE; BRAIN DERIVED NEUROTROPHIC FACTOR; DEHYDROEPIANSTROSTERONE; ESTRADIOL; ESTRIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTRONE; G PROTEIN COUPLED RECEPTOR 30; GLUTAMATE DECARBOXYLASE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; STEROID HORMONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CENTRAL NERVOUS SYSTEM FUNCTION; ENZYME ACTIVITY; GABAERGIC TRANSMISSION; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; NEUROMODULATION; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STEROIDOGENESIS;

EID: 84862837005     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2011_136     Document Type: Article

References (87)

1. Aguirre C, Jayaraman A, Pike C, Baudry M (2010) Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-b. J Neurochem 115:1277-1287
2. Ahlbom E, Prins GS, Ceccatelli S (2001) Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism. Brain Res 892:255-262
3. Amantea D, Russo R, Bagetta G, Corasaniti MT (2005) From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 52:119-132
4. Arevalo MA, Santos-Galindo M, Lagunas N, Azcoitia I, Garcia-Segura LM (2011) Selective estrogen receptor modulators as brain therapeutic agents. J Mol Endocrinol 46:R1-R9
5. Balthazart J, Ball GF (2006) Is brain estradiol a hormone or a neurotransmitter? Trends Neurosci 29:241-249
6. Balthazart J, Baillien M, Charlier TD, Cornil CA, Ball GF (2003) Multiple mechanisms control brain aromatase activity at the genomic and non-genomic level. J Steroid Biochem Mol Biol 86:367-379
7. Baulieu EE, Robel P (1996) Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids. J Endocrinol (Suppl)150:S221-S239
8. Beato M, Sanchez-Pacheco A (1996) Interaction of steroid hormone receptors with the transcription initiation complex. Endocr Rev 17:587-609
9. Beery AK, Zucker I (2011) Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev 35:565-572
10. Beyenberg S, Watzka M, Clusmann H, Blumcke I, Bidlingmaier F, Elger CE, Stoffel-Wagner B (2000) Androgen receptor mRNA expression in the human hippocampus. Neurosci Lett 94:25-28
11. Bezdickova M, Molikova R, Bebarova L, Kolar Z (2007) Distribution of nuclear receptor for steroid hormones in the human brain: a preliminary study. Biomedical Papers of the Medical Faculty of The University Palacky, Olomouc 151:69-71
12. Bodo C, Rissman EF (2006) New roles for estrogen receptor beta in behaviour and neuroendocrinology. Front Neuroendocrinol 27:217-232
13. Bowers JM, Waddell J, McCarthy MM (2010) A developmental sex difference in hippocampal neurogenesis is mediated by endogenous oestradiol. Biol Sex Differ 1:1-8
14. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ (2007) Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 193:311-321
15. Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J (2008) Progesterone receptors: form and function in brain. Front Neuroendocrinol 29:313-339
16. Brunton PJ, Russell JA (2010) Endocrine induced changes in brain function during pregnancy. Brain Res 1364:198-215
17. Caruso D, Pesaresi M, Maschi O, Garcia-Segura LM, Melcangi RC (2010) Effect of short-and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats. J Neuroendocrinol 22:1137-1147
18. Chabbert Buffet N, Djakoure C, Maitre SC, Bouchard P (1998) Regulation of the human menstrual cycle. Front Neuroendocrinol 19:151-186
19. Coughlan T, Gibson C, Murphy S (2009) Progesterone, BDNF and neuroprotection in the injured CNS. Int J Neurosci 119:1718-1740
20. Damdimopoulos AE, Spyrou G, Gustafsson JA (2000) Ligands differentially modify the nuclear ability of estrogen receptors alpha and beta. Endocrinology 149:339-345
21. Delaunay F, Pettersson K, Tujague M, Gustafsson JA (2000) Functional differences between thye amino-terminals of estrogen receptors alpha and beta. Mol Pharmacol 58:584-590
22. Dressing GE, Goldberg JE, Charles NJ, Schwertfeger KL, Lange CA (2011) Membrane progesterone receptor expression in mammalian tissues: A review of regulation and physiological implications. Steroids 76:11-17
23. Fargo KN, Foecking EM, Jones KJ, Sengelaub DR (2009) Neuroprotective actions of androgens on motoneurons. Front Neuroendocrinol 30:130-141
24. Freedman LP (1999) Multimeric coactivator complexes for steroid/nuclear receptors. Trends Endocrinol Metab 10:403-407
25. Furr BJA (2006) Aromatase inhibitors. Birkḧauser Verlag, Basel-Boston-Berlin.
26. Gao W, Dalton JT (2007) Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs). Drug Discov Today 12:241-248
27. Garcia-Segura LM, Melcangi RC (2006) Steroids and glial cell function. Glia 54:485-498
28. Garcia-Segura LM, Veiga S, Sierra A, Melcangi RC, Azcoitia I (2003) Aromatase: a neuroprotective enzyme. Prog Neurobiol 71:31-41
29. Genazzani AR, Monteleone P, Gambacciani M (2002) Hormonal influence on the central nervous system. Maturitas 43:S11-S17
30. Giangrande PH, McDonnell DP (1999) The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encodes by a single gene. Recent Prog Horm Res 54:291-313
31. Gilep AA, Sushko TA, Usanov SA (2011) At the cross-roads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17. Biochim Biophys Acta 1814:200-209
32. Gillies GE, McArthur S (2010) Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev 62:155-198
33. Goren LJG, Kruijver FPM (2002) Androgens and male behavior. Mol Cell Endocrinol 198:31-40
34. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320:134-139
35. Gustafson DR, Karlsson C, Skoog I, Rosengren L, Lissner L, Blennow K (2007) Mid-life adiposity factors relate to blood-brain barrier integrity in late life. J Intern Med 262:643-650
36. Hapgood JP, Koubovec D, Louw A, Africander D (2004) Not all progestins are the same: implications for usage. Trends Pharmacol Sci 25:554-557
37. Harrison PJ, Tunbridge EM (2008) Catechol-O-Methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology 33:3037-3045
38. Ishrat T, Sayeed I, Atif F, Hua F, Stein DG (2010) Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases. Exp Neurol 226:183-190
39. Keenan DM, Veldhuis JD (2009) Age-dependent regression analysis of male gonadal axis. Am J Physiol Regul Integr Comp Physiol 297:R1215-R1227
40. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930
41. Kumar RC, Thakur MK (2004) Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain. Neurobiol Aging 25:925-933
42. Lappano R, Rosano C, De Marco P, De Francesco EM, Pezzi V, Maggiolini M (2010) Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol 320:162-170
43. Lephart E (1996) A review of brain aromatase cytochrome P450. Brain Res Rev 22:1-26
44. Leranth C, Hajszan T, MacLusky NJ (2004) Androgens increase spine synapse density in the CA1 hippocampal subfield of ovariectomized female rats. J Neurosci 24:485-499
45. Levin-Allerhand JA, Lominska CE, Wang J, Smith JD (2002) 17Alpha-estradiol and 17betaestradiol treatment are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice. J Alzheimers Dis 4:449-457
46. Liehr JG, Roy D (1990) Free radical generation by redox cycling of estrogens. Free Radic Biol Med 8:415-423
47. Lonard DM, Lanz RB, O'Malley BW (2007) Nuclear receptor coregulators and human disease. Endocr Rev 28:575-587
48. Lubbers LS, Zafian PT, Gautreaux C, Gordon M, Alves SE, Correa L, Lorrain DS, Hickey GJ, Luine V (2010) Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain. J Steroid Biochem Mol Biol 122:310-317
49. Maggiolini M, Picard D (2010) The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 204:105-114
50. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Mark M, Chambon P, Evans RM (1995) The nuclear receptor superfamily: the second decade. Cell 83:835-839
51. Mannella P, Sanchez AM, Giretti MS, Genazzani AR, Simoncini T (2009) Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons depending on prior hormonal exposure via the induction of neural nitric oxide synthase. Steroids 74:650-656
52. Matsumoto A, Prins G (2002) Androgenic regulation of expression of androgen receptor protein in peripheral motoneurons of aged male rats. J Comp Neurol 443:383-387
53. Mesiano S (2001) Roles of estrogen and progesterone in human parturition. Front Horm Res 27:86-104
54. Million Women Study Collaborators (2003) Breast cancer and hormone replacement therapy in the Million Women Study. Lancet 362:419-427
55. Mooradian AD, Morley JE, Korenman SG (1987) Biological actions of androgens. Endocr Rev 8:1-28
56. Murphy DD, Segal M (2000) Progesterone prevents estradiol-induced dendritic spine density formation in hippocamp0la neurons. Neuroendocrinology 72:133-143
57. Nakhla AM, Hryb DJ, Hryb DJ, Rosner W, Romas NA, Xiang Z, Kahn SM (2009) Human sex hormone-binding globulin gene expression-multiple promoters and complex alternative splicing. BMC Mol Biol 10:37-55
58. Nguyen T-V, Yao M, Pike CJ (2005) Androgens activate mitogen-activated protein kinase signaling: Role in neuroprotection. J Neurochem 94:1639-1651
59. Nguyen HP, Li L, Gatson JW, Maass D, Wigginton JG, Simpkins JW, Schug KA (2011) Simultaneous quantification of four native estrogen hormones at trace levels in human cerebrospinal fluid using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 54:830-837
60. Nilsen J, Brinton RD (2002) Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 143:205-212
61. O'Malley BW (2006) Little molecules with big goals. Science 313:1749-1750
62. Österlund MK, Hurd YL (2001) Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 64(3):251-267
63. Patchev VK, Schroeder J, Goetz F, Rohde W, Patchev AV (2004) Neurotropic action of androgens: principles, mechanisms and novel targets. Exp Gerontol 39:1651-1660
64. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322
65. Pettersson H, Lundqvist J, Oliw E, Norlin M (2009) CYP7B1-mediated metabolism of 5aandrostane-3a,17b-diol (3a-Adiol):A novel pathway for potential regulation of the cellular levels of androgensand neurosteroids. Biochim Biophys Acta 1791:1206-1215
66. Picazo O, Azcoitia I, Garcia-Segura LM (2003) Neuroprotective and neurotoxic effect of estrogens. Brain Res 990:220-227
67. Pike CJ (2001) Testosterone attenuates b-amyloid toxicity in cultured hippocampal neurons. Brain Res 919:160-165
68. Pilgrim C, Hutchison JB (1994) Developmental Regulation of Sex Differences in the Brain: Can the role of the gonadal steroids be redefined. Neuroscience 604:843-855
69. Powell SM, Christiaens V, Voulgaraki D, Waxman J, Claessens F, Bevan CL (2004) Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate. Endocr Relat-Cancer 11:117-130
70. Prokal L, Simpkins JW (2007) Structure-non-genomic neuroprotection relationship of estrogens and estrogen-derived compounds. Pharmacol Ther 114:1-12
71. Reddy DS (2004) Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3a androstanediol and 17b-estradiol. Neuroscience 129:195
72. Reyes-RomeroMA (2001) The physiological role of estriol during human fetal development is to act as antioxidant at lipophilic milieus of the central nervous system. Med Hypotheses 56:107-109
73. Rohr UW (2002) The impact of testosterone imbalance on depression and women's health. Maturitas 41:S25-S46
74. Roselli CE, Resko JA (1993) Aromatase activity in the brain:hormonal regulation and sex differences. J Steroid Biochem Mol Biol 61:365-374
75. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Grenwald D, Yu CJ, Bodor N, Day LJ (1997) Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. Neurosurgery 87:724-730
76. Steckelbroeck S, Watzka M, Reichelt R, Hans VHJ, Stoffel-Wagner B, Heidrich DD, Schramm J, Bidlingmaier F, Klingmuller D (2001) Characterization of the 5a-reductase-3a-hydroxysteroid dehydrogenase complex in the human brain. J Clin Endocrinol Metab 86:1324-1331
77. Swaab DF (2007) Sexual differentiation of the brain and behavior. Best Practice & Research Clinical Endocrinology and Metabolism 21:431-444
78. Thomas P (2008) Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions. Front Neuroendocrinol 29:292-312
79. Toran-Allerand CD (2004) Estrogen and the brain: beyond ER-alpha and ER-beta. Exp Gerontol 39:1579-1586
80. Tsai MJ, O'Malley BW (1994) Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486
81. Tunbridge EM, Harrison PJ (2011) Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. Curr Topics Behav Neurosci DOI: 10.1007/7854_2010_97.
82. Wallis CJ, Luttge WG (1980) Influence of estrogen and progesterone on gluatamic acid decarboxylase activity in discrete regions of rat brain. J Neurochem 34:609-613
83. Weiser MJ, Foradori CD, Handa RJ (2008) Estrogen receptor beta in the brain: from form to function. Brain Res Rev 57:309-320
84. WHI Investigators (2003) Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women. JAMA 289(24):3243-3253
85. Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, Salomone JP, Dent LL, Harris OA, Ander DS, Lowery DW, Patel MM, Denson DD, Gordon AB, Wald MM, Gupta S, Hoffman SW, Stein DG (2007) ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med 49:391-402
86. Yore MA, Im D, Webb LK, Zhao Y, Chadwick JG, Molenda-Figueira HA, Haidacher SJ, Denner L, Tetel MJ (2010) Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors. Neuroscience 169:1017-1028
87. Zwain IH, Yen SSC (1999) Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology 140:880-887