Protective Effects of Ginsenosides against Bisphenol A-Induced Cytotoxicity in 15P-1 Sertoli Cells via Extracellular Signal-Regulated Kinase 1/2 Signalling and Antioxidant Mechanisms

Basic and Clinical Pharmacology and Toxicology

Volumn 111, Issue 1, 2012, Pages 42-49

  Wang, Limin ^a   Hao, Jie ^b   Hu, Jiangang ^a,c   Pu, Jun ^b   Lü, Zilan ^a   Zhao, Lina ^a   Wang, Qi ^a   Yu, Qiubo ^a   Wang, Yingxiong ^a   Li, Gang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^c The People's Hospital of Dazu Country   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANTIOXIDANT; GINSENOSIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; VIMENTIN;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; IMMUNOFLUORESCENCE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERTOLI CELL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; GINSENOSIDES; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHENOLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; SERTOLI CELLS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

PANAX GINSENG;

EID: 84862827706     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2012.00857.x     Document Type: Article

References (55)

1. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for deacreasing quality of semen during past 50 years. Br Med J 1992;305:609-13.
2. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C et al. National cooperative reproductive medicine network. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001;345:1388-13893.
3. Irvine DS. Epidemiology and aetiology of male infertility. Hum Reprod 1998;13(Suppl 1):33-44.
4. Paasch U, Salzbrunn A, Glander HJ, Plambeck K, Salzbrunn H, Grunewald S et al. Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. Int J Androl 2008;31:93-102.
5. Hauser R. The environment and male fertility: recent research on emerging chemicals and semen quality. Semin Reprod Med 2006;24:156-67.
6. Petrelli G, Mantovani A. Environmental risk factors and male fertility and reproduction. Contraception 2002;65:297-300.
7. Patisaul HB, Adewale HB. Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior. Front Behav Neurosci 2009;3:10.
8. U.S. Food and Drug Administration. Update on bisphenol a for use in food contact applications. 2010.
9. Staples CA, Dorn PB, Klecka GM, O'Block ST, Harris LR. A review of the environmental fate, effects, and exposures of bisphenol A. Chemosphere 1998;36:2149-73.
10. Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev 2009;30:75-95.
11. Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, Talsness CE et al. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 2007;24:199-224.
12. Al-Hiyasat AS, Darmani H, Elbetieha AM. Effects of bisphenol A on adult male mouse fertility. Eur J Oral Sci 2002;110:163-7.
13. Takahashi O, Oishi S. Testicular toxicity of dietary 2, 2-bis(4-hydroxyphenly)propane (bisphenol A) in F344 rats. Arch Toxicol 2001;75:42-51.
14. Toyama Y, Suzuki-Toyota F, Maekawa M, Ito C, Toshimori K. Adverse effects of bisphenol A to spermiogenesis in mice and rats. Arch Histol Cytol 2004;67:373-81.
15. Toyama Y, Yuasa S. Effects of neonatal administration of 17beta-estradiol, beta-estradiol 3-benzoate, or bisphenol A on mouse and rat spermatogenesis. Reprod Toxicol 2004;19:181-8.
16. Li MW, Mruk DD, Lee WM, Cheng CY. Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics? Int J Biochem Cell Biol 2009;41:2302-14.
17. Farabollini F, Porrini S, Della Seta D, Bianchi F, Dessi-Fulgheri F. Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats. Environ Health Perspect 2002;110(Suppl 3):409-14.
18. Bahrke MS, Morgan WR. Evaluation of the ergogenic properties of ginseng: an update. Sports Med 2000;29:113-33.
19. Coleman CI, Hebert JH, Reddy P. The effects of Panax ginseng on quality of life. J Clin Pharm Ther 2003;28:5-15.
20. Xiang YZ, Shang HC, Gao XM, Zhang BL. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res 2008;22:851-8.
21. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-8.
22. Kumar M, Sharma MK, Saxena PS, Kumar A. Radioprotective effect of Panax ginseng on the phosphatases and lipid peroxidation level in testes of Swiss albino mice. Biol Pharm Bull 2003;26:308-12.
23. Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-6.
24. Naval MV, Gómez-Serranillos MP, Carretero ME, Villar AM. Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocytes primary culture. J Ethnopharmacol 2007;112:262-70.
25. Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 2006;11:128-50.
26. Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M et al. Effects of Panax ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38:249-54.
27. Park JS, Hwang SY, Lee WS, Yu KW, Paek KY, Hwang BY et al. The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder. Arch Pharm Res 2006;29:800-7.
28. Lee JH, Sul D, Oh E, Jung WW, Hwang KW, Hwang TS et al. Panax ginseng effects on DNA damage, CYP1A1 expression and histopathological changes in testes of rats exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Food Chem Toxicol 2007;45:2237-44.
29. Park WH, Chang MS, Yang WM, Bae H, Kim NI, Park SK. Cytoprotective effect of Panax ginseng on gallic acid-induced toxicity in TM3 mouse Leydig cells. Fitoterapia 2007;78:577-9.
30. de Kretser DM, Loveland KL, Meinhardt A, Simorangkir D, Wreford N. Spermatogenesis. Hum Reprod 1998;13(Suppl 1):1-8.
31. Bernard L, Martinat N, Lécureuil C, Crépieux P, Reiter E, Tilloy-Ellul A et al. Dichlorodiphenyltrichloroethane impairs follicle-stimulating hormone receptor-mediated signaling in rat Sertoli cells. Reprod Toxicol 2007;23:158-64.
32. Gong Y, Pan X, Huang Y, Gao Z, Yu H, Han X. NP-induced biophysical and biochemical alterations of rat testicular Sertoli cell membranes related to disturbed intracellular Ca(2+) homeostasis. Toxicol Lett 2008;183:10-20.
33. Kleymenova E, Swanson C, Boekelheide K, Gaido KW. NP- Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact. Biol Reprod 2005;73:482-90.
34. Monsees TK, Franz M, Gebhardt S, Winterstein U, Schill WB, Hayatpour J. Sertoli cells as a target for reproductive hazards. Andrologia 2000;32:239-46.
35. Orini C, Tilloy-Ellul A, Chevalier S, Charuel C, Pointis G. Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. Reprod Toxicol 2004;18:413-21.
36. Siu ER, Mruk DD, Porto CS, Cheng Y. Cadmium-induced testicular injury. Toxicol Appl Pharmacol 2009;238:240-9.
37. Paramio JM, Jorcano JL. Beyond structure: do intermediate filaments modulate cell signalling? Bioessays 2002;24:836-44.
38. Show MD, Anway MD, Folmer JS, Zirkin BR. Reduced intratesticular testosterone concentration alters the polymerization state of the Sertoli cell intermediate filament cytoskeleton by degradation of vimentin. Endocrinology 2003;144:5530-6.
39. Kopecky M, Semecky V, Nachtigal P. Vimentin expression during altered spermatogenesis in rats. Acta Histochem 2005;107:279-89.
40. Wang ZQ, Watanabe Y, Toki A, Itano T. Altered distribution of Sertoli cell vimentin and increased apoptosis in cryptorchid rats. J Pediatr Surg 2002;37:648-52.
41. He D, Zhang D, Wei G, Lin T, Li X. Cytoskeleton vimentin disruption of mouse Sertoli cells injured by nitrogen mustard in vitro. J Androl 2007;28:389-96.
42. Chen M, Cai H, Yang JL, Lu CL, Liu T, Yang W et al. Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey Sertoli cells. Endocrinology 2008;149:4871-82.
43. Richburg JH, Boekelheide K. Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes. Toxicol Appl Pharmacol 1996;137:42-50.
44. Alam MS, Ohsako S, Tay TW, Tsunekawa N, Kanai Y, Kurohmaru M. Di(n-butyl). Phthalate induces vimentin filaments disruption in rat Sertoli cells: a possible relation with spermatogenic cell apoptosis. Anat Histol Embryol 2010;39:186-93.
45. Cuevas BD, Abell AN, Johnson GL. Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 2007;26:3159-71.
46. Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci 2006;31:268-75.
47. Li MW, Mruk DD, Cheng CY. Mitogen-activated protein kinases in male reproductive function. Trends Mol Med 2009;15:159-68.
48. Thuillier R, Manku G, Wang Y, Culty M. Changes in MAPK pathway in neonatal and adult testis following fetal estrogen exposure and effects on rat testicular cells. Microsc Res Tech 2009;72:773-86.
49. Lui WY, Cheng CY. Regulation of cell junction dynamics by cytokines in the testis: a molecular and biochemical perspective. Cytokine Growth Factor Rev 2007;18:299-311.
50. Almog T, Lazar S, Reiss N, Etkovitz N, Milch E, Rahamim N et al. Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality. J Biol Chem 2008;283:14479-14489.
51. Makker K, Agarwal A, Sharma R. Oxidative stress & male infertility. Indian J Med Sci 2009;129:357-67.
52. Sheweita SA, Tilmisany AM, A1-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab 2005;6:495-501.
53. Karadeniz A, Cemek M, Simsek N. The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats. Ecotoxicol Environ Saf 2009;72:231-5.
54. Zhao H, Li Q, Zhang Z, Pei X, Wang J, Li Y. Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus. Brain Res 2009;1256:111-22.
55. Zhang QH, Wu CF, Duan L, Yang JY. Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells. Food Chem Toxicol 2008;46:293-302.