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Volumn 46, Issue 1, 2008, Pages 293-302

Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells

Author keywords

Anti oxidant enzyme; Comet assay; Cyclophosphamide; GSH; Total saponins of Panax ginseng

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLOPHOSPHAMIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; PHOSPHATIDYLSERINE; SAPONIN DERIVATIVE; SUPEROXIDE DISMUTASE;

EID: 36849093425     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.025     Document Type: Article
Times cited : (86)

References (82)
  • 1
    • 0021090338 scopus 로고
    • Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice
    • Aburada M., Takeda S., Ito E., Nakamura M., and Hosoya E. Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice. J. Pharmacobiodyn. 6 (1983) 1000-1004
    • (1983) J. Pharmacobiodyn. , vol.6 , pp. 1000-1004
    • Aburada, M.1    Takeda, S.2    Ito, E.3    Nakamura, M.4    Hosoya, E.5
  • 3
    • 0031755770 scopus 로고    scopus 로고
    • Comet assay responses as indicators of carcinogen exposure
    • Anderson D., Tian-wei Y., and McGregor D.B. Comet assay responses as indicators of carcinogen exposure. Mutagenesis 13 (1998) 539-555
    • (1998) Mutagenesis , vol.13 , pp. 539-555
    • Anderson, D.1    Tian-wei, Y.2    McGregor, D.B.3
  • 4
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: multiple constituents and multiple actions
    • Attele A.S., Wu J.A., and Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pahrmacol. 58 (1999) 1685-1693
    • (1999) Biochem. Pahrmacol. , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 6
    • 3543144845 scopus 로고    scopus 로고
    • Parallel evaluation of doxorubicin-induced genetic damage in human lymphocytes and sperm using the comet assay and spectral karyotyping
    • Baumgartner A., Schmid T.E., Cemeli E., and Anderson D. Parallel evaluation of doxorubicin-induced genetic damage in human lymphocytes and sperm using the comet assay and spectral karyotyping. Mutagenesis 19 (2004) 313-318
    • (2004) Mutagenesis , vol.19 , pp. 313-318
    • Baumgartner, A.1    Schmid, T.E.2    Cemeli, E.3    Anderson, D.4
  • 7
    • 0033378084 scopus 로고    scopus 로고
    • Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes
    • Benitez-Bribiesca L., and Sanchez-Suarez P. Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes. A Comet Assay Study. Ann. NY Acad. Sci. 887 (1999) 133-149
    • (1999) A Comet Assay Study. Ann. NY Acad. Sci. , vol.887 , pp. 133-149
    • Benitez-Bribiesca, L.1    Sanchez-Suarez, P.2
  • 8
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • Beutler E., Duron O., and Kelly B.M. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61 (1963) 882-888
    • (1963) J. Lab. Clin. Med. , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 9
    • 0025185778 scopus 로고
    • The early history of the biological alkylating agents
    • Brookes P. The early history of the biological alkylating agents. Mutat. Res. 233 (1990) 3-14
    • (1990) Mutat. Res. , vol.233 , pp. 3-14
    • Brookes, P.1
  • 10
    • 0027892639 scopus 로고
    • Effect of combined treatment with interleukin-3 and interleukin-6 on 4- hydroperoxycyclo-phosphamide-induced programmed cell death or apoptosis in human myeloid leukemia cells
    • Bullock G., Tang C., Tourkina E., Ibrado A.M., Lutzky J., Huang Y., Mahoney M.E., and Bhalla K. Effect of combined treatment with interleukin-3 and interleukin-6 on 4- hydroperoxycyclo-phosphamide-induced programmed cell death or apoptosis in human myeloid leukemia cells. Exp. Hematol. 21 (1993) 1640-1647
    • (1993) Exp. Hematol. , vol.21 , pp. 1640-1647
    • Bullock, G.1    Tang, C.2    Tourkina, E.3    Ibrado, A.M.4    Lutzky, J.5    Huang, Y.6    Mahoney, M.E.7    Bhalla, K.8
  • 11
    • 0032787082 scopus 로고    scopus 로고
    • Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng
    • Chang M.S., Lee S.G., and Rho H.M. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytother. Res. 13 (1999) 641-644
    • (1999) Phytother. Res. , vol.13 , pp. 641-644
    • Chang, M.S.1    Lee, S.G.2    Rho, H.M.3
  • 12
    • 36849088952 scopus 로고    scopus 로고
    • Observation of curalive effect of combined 20(R)-ginsenoside Rg3 with chemotherapy on non-small - cell lung cancers
    • Chen M.W., Yao Y., and Shi Z.H. Observation of curalive effect of combined 20(R)-ginsenoside Rg3 with chemotherapy on non-small - cell lung cancers. Milit. Med. J. South China 19 (2005) 4-6
    • (2005) Milit. Med. J. South China , vol.19 , pp. 4-6
    • Chen, M.W.1    Yao, Y.2    Shi, Z.H.3
  • 13
    • 13444293396 scopus 로고    scopus 로고
    • Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action
    • Cheng Y., Shen L.H., and Zhang J.T. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol. Sin. 26 (2005) 143-149
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 143-149
    • Cheng, Y.1    Shen, L.H.2    Zhang, J.T.3
  • 14
    • 5144233210 scopus 로고    scopus 로고
    • Use of whole blood directly for single-cell gel electrophoresis (comet) assay in vivo and white blood cells for in vitro assay
    • Chuang C.H., and Hu M.L. Use of whole blood directly for single-cell gel electrophoresis (comet) assay in vivo and white blood cells for in vitro assay. Mutat. Res. 564 (2004) 75-82
    • (2004) Mutat. Res. , vol.564 , pp. 75-82
    • Chuang, C.H.1    Hu, M.L.2
  • 15
    • 0032826199 scopus 로고    scopus 로고
    • An overview of cyclophosphamide development and clinical applications
    • Colvin O.M. An overview of cyclophosphamide development and clinical applications. Curr. Pharm. Des. 5 (1999) 555-560
    • (1999) Curr. Pharm. Des. , vol.5 , pp. 555-560
    • Colvin, O.M.1
  • 16
    • 0022452407 scopus 로고
    • Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells
    • Crook T.R., Souhami R.L., and McLean A.E. Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells. Cancer Res. 46 (1986) 5029-5034
    • (1986) Cancer Res. , vol.46 , pp. 5029-5034
    • Crook, T.R.1    Souhami, R.L.2    McLean, A.E.3
  • 17
    • 0022444380 scopus 로고
    • Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide
    • Crook T.R., Souhami R.L., Whyman G.D., and McLean A.E. Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide. Cancer Res. 46 (1986) 5035-5038
    • (1986) Cancer Res. , vol.46 , pp. 5035-5038
    • Crook, T.R.1    Souhami, R.L.2    Whyman, G.D.3    McLean, A.E.4
  • 18
    • 0035045748 scopus 로고    scopus 로고
    • Flow cytometry in analysis of cell cycle and apoptosis
    • Darzynkiewicz Z., Bedner E., and Smolewski P. Flow cytometry in analysis of cell cycle and apoptosis. Semin. Hematol. 38 (2001) 179-193
    • (2001) Semin. Hematol. , vol.38 , pp. 179-193
    • Darzynkiewicz, Z.1    Bedner, E.2    Smolewski, P.3
  • 19
    • 0028937961 scopus 로고
    • Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress
    • Das D.K., Maulik N., and Moraru II. Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress. J. Mol. Cell. Cardiol. 27 (1995) 181-193
    • (1995) J. Mol. Cell. Cardiol. , vol.27 , pp. 181-193
    • Das, D.K.1    Maulik, N.2    Moraru, II.3
  • 21
    • 36849049160 scopus 로고    scopus 로고
    • Comparison research of whole blood specimen and abstracted lymphocyte in comet assay
    • Duan L., Yang J.Y., Yu H., and Wu C.F. Comparison research of whole blood specimen and abstracted lymphocyte in comet assay. Carcinogen. Teratogene. Mutagene. 16 (2004) 307-309
    • (2004) Carcinogen. Teratogene. Mutagene. , vol.16 , pp. 307-309
    • Duan, L.1    Yang, J.Y.2    Yu, H.3    Wu, C.F.4
  • 24
    • 0018938396 scopus 로고
    • Cytotoxicity and DNA cross-linking activity of 4-sulfidocyclophosphamides in mouse leukemia cells in vitro
    • Erickson L.C., Ramonas L.M., Zaharko D.S., and Kohn K.W. Cytotoxicity and DNA cross-linking activity of 4-sulfidocyclophosphamides in mouse leukemia cells in vitro. Cancer Res. 40 (1980) 4216-4220
    • (1980) Cancer Res. , vol.40 , pp. 4216-4220
    • Erickson, L.C.1    Ramonas, L.M.2    Zaharko, D.S.3    Kohn, K.W.4
  • 26
    • 0029838904 scopus 로고    scopus 로고
    • The clinical use of mutagenic anti-cancer drugs
    • Ferguson L.R., and Pearson A.E. The clinical use of mutagenic anti-cancer drugs. Mutat. Res. 355 (1996) 1-12
    • (1996) Mutat. Res. , vol.355 , pp. 1-12
    • Ferguson, L.R.1    Pearson, A.E.2
  • 28
    • 0016414528 scopus 로고
    • Superoxide dismutases
    • Fridovich I. Superoxide dismutases. Annu. Rev. Biochem. 44 (1975) 147-159
    • (1975) Annu. Rev. Biochem. , vol.44 , pp. 147-159
    • Fridovich, I.1
  • 29
    • 0026032095 scopus 로고
    • A simple method for determination of serum catalase activity and revision of reference range
    • Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clin. Chim. Acta 196 (1991) 143-151
    • (1991) Clin. Chim. Acta , vol.196 , pp. 143-151
    • Goth, L.1
  • 30
    • 0032544268 scopus 로고    scopus 로고
    • Apoptotic pathways: the roads to ruin
    • Green D.R. Apoptotic pathways: the roads to ruin. Cell 94 (1998) 695-698
    • (1998) Cell , vol.94 , pp. 695-698
    • Green, D.R.1
  • 31
    • 0030694580 scopus 로고    scopus 로고
    • Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1
    • Hengstler J.G., Hengst A., Fuchs J., Tanner B., Pohl J., and Oesch F. Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1. Mutat. Res. 373 (1997) 215-223
    • (1997) Mutat. Res. , vol.373 , pp. 215-223
    • Hengstler, J.G.1    Hengst, A.2    Fuchs, J.3    Tanner, B.4    Pohl, J.5    Oesch, F.6
  • 32
    • 0024594731 scopus 로고
    • Effects of ginseng saponins on the survival of cerebral cortex neurons in cell cultures
    • Himi T., Saito H., and Nishiyama N. Effects of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chem. Pharm. Bull. 37 (1989) 481-484
    • (1989) Chem. Pharm. Bull. , vol.37 , pp. 481-484
    • Himi, T.1    Saito, H.2    Nishiyama, N.3
  • 33
    • 32944469640 scopus 로고    scopus 로고
    • Experimental study on anti-angiogenesis in mice with Lewis lung carcinoma by low-dose of cyclophosphamide combined with ginsenoside Rg3
    • Kang X.M., Zhang Q.Y., Tong D.D., and Zhao W. Experimental study on anti-angiogenesis in mice with Lewis lung carcinoma by low-dose of cyclophosphamide combined with ginsenoside Rg3. Zhongguo Zhong Xi Yi Jie He Za Zhi 25 (2005) 730-733
    • (2005) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.25 , pp. 730-733
    • Kang, X.M.1    Zhang, Q.Y.2    Tong, D.D.3    Zhao, W.4
  • 34
    • 0032717659 scopus 로고    scopus 로고
    • The effect of melatonin application on lipid peroxidation during cyclophosphamide therapy in female rats
    • Kaya H., Oral B., Ozguner F., Tahan V., Babar Y., and Delibas N. The effect of melatonin application on lipid peroxidation during cyclophosphamide therapy in female rats. Zentralbl Gynakol 121 (1999) 499-502
    • (1999) Zentralbl Gynakol , vol.121 , pp. 499-502
    • Kaya, H.1    Oral, B.2    Ozguner, F.3    Tahan, V.4    Babar, Y.5    Delibas, N.6
  • 35
    • 0033864802 scopus 로고    scopus 로고
    • The molecular effect of acrolein
    • Kehrer J.P., and Biswal S.S. The molecular effect of acrolein. Toxicol. Sci. 57 (2000) 6-15
    • (2000) Toxicol. Sci. , vol.57 , pp. 6-15
    • Kehrer, J.P.1    Biswal, S.S.2
  • 37
    • 0000626726 scopus 로고    scopus 로고
    • Transcriptional activation of the Cu, Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng
    • Kim Y.H., Park K.H., and Rho H.M. Transcriptional activation of the Cu, Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng. J. Biol. Chem. 271 (1996) 24539-24543
    • (1996) J. Biol. Chem. , vol.271 , pp. 24539-24543
    • Kim, Y.H.1    Park, K.H.2    Rho, H.M.3
  • 39
    • 0026657495 scopus 로고
    • Effects of cyclophosphamide and adriamycin on rat hepatic microsomal glucuronidation and lipid peroxidation
    • Lear L., Nation R.L., and Stupans I. Effects of cyclophosphamide and adriamycin on rat hepatic microsomal glucuronidation and lipid peroxidation. Biochem. Pharmacol. 44 (1992) 747-753
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 747-753
    • Lear, L.1    Nation, R.L.2    Stupans, I.3
  • 40
    • 0343832165 scopus 로고    scopus 로고
    • Oncosis is associated with exposure of phosphatidylserine residues on the outside layer of the plasma membrane: a reconsideration of the specificity of the annexin V/propidium iodide assay
    • Lecoeur H., Prevost M.C., and Gougeon M.L. Oncosis is associated with exposure of phosphatidylserine residues on the outside layer of the plasma membrane: a reconsideration of the specificity of the annexin V/propidium iodide assay. Cytometry 44 (2001) 65-72
    • (2001) Cytometry , vol.44 , pp. 65-72
    • Lecoeur, H.1    Prevost, M.C.2    Gougeon, M.L.3
  • 42
    • 36849048662 scopus 로고    scopus 로고
    • The efficacy analysis of low-dose cyclophosphamide combined with gimenoside Rg3 on advanced non-small cell lung cancer
    • Li H.B., Liu W.L., Zhang Q.Y., Kang X.M., and Zhao W.H. The efficacy analysis of low-dose cyclophosphamide combined with gimenoside Rg3 on advanced non-small cell lung cancer. J. Pract. Oncol. 20 (2006) 18-20
    • (2006) J. Pract. Oncol. , vol.20 , pp. 18-20
    • Li, H.B.1    Liu, W.L.2    Zhang, Q.Y.3    Kang, X.M.4    Zhao, W.H.5
  • 43
    • 0028967849 scopus 로고
    • Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells
    • Lin F., Jackson V.E., and Girotti A.W. Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells. Arch. Biochem. Biophys. 317 (1995) 7-18
    • (1995) Arch. Biochem. Biophys. , vol.317 , pp. 7-18
    • Lin, F.1    Jackson, V.E.2    Girotti, A.W.3
  • 44
    • 0026504109 scopus 로고
    • Recent advances on ginseng research in China
    • Liu C.X., and Xiao P.G. Recent advances on ginseng research in China. J. Ethnopharmacol. 36 (1992) 27-38
    • (1992) J. Ethnopharmacol. , vol.36 , pp. 27-38
    • Liu, C.X.1    Xiao, P.G.2
  • 45
    • 0037462036 scopus 로고    scopus 로고
    • In vitro study of the relationship between the structure of ginsenoside and its anti-oxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes
    • Liu Z.Q., Luo X.Y., Liu G.Z., Chen Y.P., Wang Z.C., and Sun Y.X. In vitro study of the relationship between the structure of ginsenoside and its anti-oxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. J. Agri. Food Chem. 51 (2003) 2555-2558
    • (2003) J. Agri. Food Chem. , vol.51 , pp. 2555-2558
    • Liu, Z.Q.1    Luo, X.Y.2    Liu, G.Z.3    Chen, Y.P.4    Wang, Z.C.5    Sun, Y.X.6
  • 46
    • 0028235612 scopus 로고
    • Pharmacokinetic drug interactions with anti-cancer drugs
    • Loadman P.M., and Bibby M.C. Pharmacokinetic drug interactions with anti-cancer drugs. Clin. Pharmacokinet. 26 (1994) 486-500
    • (1994) Clin. Pharmacokinet. , vol.26 , pp. 486-500
    • Loadman, P.M.1    Bibby, M.C.2
  • 47
    • 0031422883 scopus 로고    scopus 로고
    • Anti-oxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity
    • Mathew S., and Kuttan G. Anti-oxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J. Exp. Clin. Cancer Res. 16 (1997) 407-411
    • (1997) J. Exp. Clin. Cancer Res. , vol.16 , pp. 407-411
    • Mathew, S.1    Kuttan, G.2
  • 48
    • 0037186342 scopus 로고    scopus 로고
    • Flow cytometric estimation of the plasma membrane diversity of bone marrow cells in mice treated with WR-2721 and cyclophosphamide
    • Mazur L., Augustynek A., and Bochenek M. Flow cytometric estimation of the plasma membrane diversity of bone marrow cells in mice treated with WR-2721 and cyclophosphamide. Toxicology 171 (2002) 63-72
    • (2002) Toxicology , vol.171 , pp. 63-72
    • Mazur, L.1    Augustynek, A.2    Bochenek, M.3
  • 50
    • 0034142356 scopus 로고    scopus 로고
    • Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide,heat shock, and staurosporine
    • Mirkes P.E., and Little S.A. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide,heat shock, and staurosporine. Toxicol. Appl. Pharmacol. 162 (2000) 197-206
    • (2000) Toxicol. Appl. Pharmacol. , vol.162 , pp. 197-206
    • Mirkes, P.E.1    Little, S.A.2
  • 52
    • 0029098678 scopus 로고
    • Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng
    • Mochizuki M., Yoo C.Y., Matsuzawa K., Sato K., Saiki I., Tono-oka S., Samukawa K., and Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol. Pharm. Bull. 18 (1995) 1197-1202
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 1197-1202
    • Mochizuki, M.1    Yoo, C.Y.2    Matsuzawa, K.3    Sato, K.4    Saiki, I.5    Tono-oka, S.6    Samukawa, K.7    Azuma, I.8
  • 53
    • 0026100542 scopus 로고
    • Clinical pharmacokinetics of cyclophosphamide
    • Moore M.J. Clinical pharmacokinetics of cyclophosphamide. Clin. Pharmacokinet. 20 (1991) 194-208
    • (1991) Clin. Pharmacokinet. , vol.20 , pp. 194-208
    • Moore, M.J.1
  • 54
    • 0021221090 scopus 로고
    • Induction of DNA damage by menadione (2-methyl-l,4-naphthoquinone) in primary cultures of rat hepatocytes
    • Morrison H., Jernstrom B., Nordenskjold M., Thor H., and Orrenius S. Induction of DNA damage by menadione (2-methyl-l,4-naphthoquinone) in primary cultures of rat hepatocytes. Biochem. Pharmacol. 33 (1984) 1763-1769
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 1763-1769
    • Morrison, H.1    Jernstrom, B.2    Nordenskjold, M.3    Thor, H.4    Orrenius, S.5
  • 55
    • 0016639130 scopus 로고
    • Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system
    • Nishikimi M. Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system. Biochem. Biophys. Res. Commun. 63 (1975) 463-468
    • (1975) Biochem. Biophys. Res. Commun. , vol.63 , pp. 463-468
    • Nishikimi, M.1
  • 56
    • 0022391637 scopus 로고
    • Cyclophosphamide-induced depression of the anti-oxidant defense mechanisms of the lung
    • Patel J.M., and Block E.R. Cyclophosphamide-induced depression of the anti-oxidant defense mechanisms of the lung. Exp. Lung Res. 8 (1985) 153-165
    • (1985) Exp. Lung Res. , vol.8 , pp. 153-165
    • Patel, J.M.1    Block, E.R.2
  • 57
    • 0030012151 scopus 로고    scopus 로고
    • Detection of DNA-crosslinking agents with the alkaline comet assay
    • Pfuhler S., and Uwe W. Detection of DNA-crosslinking agents with the alkaline comet assay. Environ. Mol. Mutagen. 27 (1996) 196-201
    • (1996) Environ. Mol. Mutagen. , vol.27 , pp. 196-201
    • Pfuhler, S.1    Uwe, W.2
  • 60
    • 0031555384 scopus 로고    scopus 로고
    • In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in multiple organ study in the mouse
    • Sasaki Y.F., Saga A., Akasaka M., Nishidate E., Watanabe-Akanuma M., Ohta T., Matsusaka N., and Tsuda S. In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in multiple organ study in the mouse. Mutat. Res. 395 (1997) 57-73
    • (1997) Mutat. Res. , vol.395 , pp. 57-73
    • Sasaki, Y.F.1    Saga, A.2    Akasaka, M.3    Nishidate, E.4    Watanabe-Akanuma, M.5    Ohta, T.6    Matsusaka, N.7    Tsuda, S.8
  • 61
    • 0028340930 scopus 로고
    • Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2
    • Sato K., Mochizuki M., Saiki I., Yoo Y.C., Samukawa K., and Azuma I. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol. Pharm. Bull. 17 (1994) 635-639
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 635-639
    • Sato, K.1    Mochizuki, M.2    Saiki, I.3    Yoo, Y.C.4    Samukawa, K.5    Azuma, I.6
  • 63
    • 33644766038 scopus 로고    scopus 로고
    • Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy
    • Shen X., Zheng S., Metreveli N.S., and Epstein P.N. Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes 55 (2006) 798-805
    • (2006) Diabetes , vol.55 , pp. 798-805
    • Shen, X.1    Zheng, S.2    Metreveli, N.S.3    Epstein, P.N.4
  • 64
    • 0021332334 scopus 로고
    • Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumour cells resistant to l-phenylalanine mustard
    • Somfai-Relle S., Suzukake K., Vistica B.P., and Vistica D.T. Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumour cells resistant to l-phenylalanine mustard. Biochem. Pharmacol. 33 (1984) 485-490
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 485-490
    • Somfai-Relle, S.1    Suzukake, K.2    Vistica, B.P.3    Vistica, D.T.4
  • 65
    • 0036786572 scopus 로고    scopus 로고
    • Differential amplification of gene expression in lens cell lines conditioned to survive peroxide stress
    • Spector A., Li D., Ma W., Sun F., and Pavlidis P. Differential amplification of gene expression in lens cell lines conditioned to survive peroxide stress. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3251-3264
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , pp. 3251-3264
    • Spector, A.1    Li, D.2    Ma, W.3    Sun, F.4    Pavlidis, P.5
  • 66
    • 0032604577 scopus 로고    scopus 로고
    • The comet assay (singe-cell gel test). A sensitive genotoxicity test for the detection of DNA damage in individual cells
    • Speit G., and Hartmann A. The comet assay (singe-cell gel test). A sensitive genotoxicity test for the detection of DNA damage in individual cells. Meth. Mol. Biol. 113 (1999) 203-212
    • (1999) Meth. Mol. Biol. , vol.113 , pp. 203-212
    • Speit, G.1    Hartmann, A.2
  • 67
    • 0032831848 scopus 로고    scopus 로고
    • Bcl-2 expression correlates with apoptosis induction but not tumor growth delay in transplantable murine lymphomas treated with different chemotherapy drugs
    • Story M.D., Mirkovic N., Hunter N., and Meyn R.E. Bcl-2 expression correlates with apoptosis induction but not tumor growth delay in transplantable murine lymphomas treated with different chemotherapy drugs. Cancer Chemother. Pharmacol. 44 (1999) 367-371
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 367-371
    • Story, M.D.1    Mirkovic, N.2    Hunter, N.3    Meyn, R.E.4
  • 68
    • 0033582526 scopus 로고    scopus 로고
    • Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
    • Sun X.M., MacFarlane M., Zhuang J., Wolf B.B., Green D.R., and Cohen G.M. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 274 (1999) 5053-5060
    • (1999) J. Biol. Chem. , vol.274 , pp. 5053-5060
    • Sun, X.M.1    MacFarlane, M.2    Zhuang, J.3    Wolf, B.B.4    Green, D.R.5    Cohen, G.M.6
  • 69
    • 0035651290 scopus 로고    scopus 로고
    • Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer
    • Surh Y.J., Na H.K., Lee J.Y., and Keum Y.S. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J. Kor. Med. Sci. 16 (2001) 38-41
    • (2001) J. Kor. Med. Sci. , vol.16 , pp. 38-41
    • Surh, Y.J.1    Na, H.K.2    Lee, J.Y.3    Keum, Y.S.4
  • 70
    • 20444471551 scopus 로고    scopus 로고
    • Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    • Thiruchelvam M., Prokopenko O., Cory-Slechta D.A., Richfield E.K., Buckley B., and Mirochnitchenko O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J. Biol. Chem. 280 (2005) 22530-22539
    • (2005) J. Biol. Chem. , vol.280 , pp. 22530-22539
    • Thiruchelvam, M.1    Prokopenko, O.2    Cory-Slechta, D.A.3    Richfield, E.K.4    Buckley, B.5    Mirochnitchenko, O.6
  • 71
    • 0034643405 scopus 로고    scopus 로고
    • The alkialine singe cell electrophoresis assay with eight mouse organs: results with 22 mono-function alkyaline agents (including 9 diakyl-nitrosoamines) and 10 DNA crosslinkers
    • Tsuda S., Matsusaka N., Madarame H., Miyamae Y., Ishida K., Satoh M., Sekihashi K., and Sasaki Y.S. The alkialine singe cell electrophoresis assay with eight mouse organs: results with 22 mono-function alkyaline agents (including 9 diakyl-nitrosoamines) and 10 DNA crosslinkers. Mutat. Res. 467 (2000) 83-98
    • (2000) Mutat. Res. , vol.467 , pp. 83-98
    • Tsuda, S.1    Matsusaka, N.2    Madarame, H.3    Miyamae, Y.4    Ishida, K.5    Satoh, M.6    Sekihashi, K.7    Sasaki, Y.S.8
  • 72
  • 73
    • 0028955691 scopus 로고
    • Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory anti-oxidant
    • Venkatesan N., and Chandrakasan G. Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory anti-oxidant. Mol. Cell Biochem. 142 (1995) 79-87
    • (1995) Mol. Cell Biochem. , vol.142 , pp. 79-87
    • Venkatesan, N.1    Chandrakasan, G.2
  • 75
    • 0031303557 scopus 로고    scopus 로고
    • In vivo anti-metastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolism after oral administration
    • Wakabayashi C., Hasegawa H., Murata J., and Saiki I. In vivo anti-metastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolism after oral administration. Oncol. Res. 9 (1997) 411-417
    • (1997) Oncol. Res. , vol.9 , pp. 411-417
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4
  • 76
    • 33645702638 scopus 로고    scopus 로고
    • Ginsenoside Rh(2) enhances anti-tumour activity and decreases genotoxic effect of cyclophosphamide
    • Wang Z., Zheng Q., Liu K., Li G., and Zheng R. Ginsenoside Rh(2) enhances anti-tumour activity and decreases genotoxic effect of cyclophosphamide. Bas. Clin. Pharmacol. Toxicol. 98 (2006) 411-415
    • (2006) Bas. Clin. Pharmacol. Toxicol. , vol.98 , pp. 411-415
    • Wang, Z.1    Zheng, Q.2    Liu, K.3    Li, G.4    Zheng, R.5
  • 77
    • 0029655506 scopus 로고    scopus 로고
    • Ginseng root prevents learning disability and neuronal loss in gerbils with 5 min forebrain ischaemia
    • Wen T.C., Yoshimura H., Matsuda S., Lim J.H., and Sakanaka M. Ginseng root prevents learning disability and neuronal loss in gerbils with 5 min forebrain ischaemia. Acta Neuropathol. 91 (1996) 15-22
    • (1996) Acta Neuropathol. , vol.91 , pp. 15-22
    • Wen, T.C.1    Yoshimura, H.2    Matsuda, S.3    Lim, J.H.4    Sakanaka, M.5
  • 79
    • 0026329287 scopus 로고
    • Expression of catalase and myeloperoxidase genes in hydrogen peroxide-resistant HL-60 cells
    • Yamada M., Hashinaka K., Inazawa J., and Abe T. Expression of catalase and myeloperoxidase genes in hydrogen peroxide-resistant HL-60 cells. DNA Cell Biol. 10 (1991) 735-742
    • (1991) DNA Cell Biol. , vol.10 , pp. 735-742
    • Yamada, M.1    Hashinaka, K.2    Inazawa, J.3    Abe, T.4
  • 80
    • 32944477601 scopus 로고    scopus 로고
    • Targeting angiogenesis with integrative cancer therapies
    • Yance Jr. D.R., and Sagar S.M. Targeting angiogenesis with integrative cancer therapies. Integr. Cancer Ther. 5 (2006) 9-29
    • (2006) Integr. Cancer Ther. , vol.5 , pp. 9-29
    • Yance Jr., D.R.1    Sagar, S.M.2
  • 81
    • 1042304295 scopus 로고    scopus 로고
    • Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice
    • Yokozawa T., Satoh A., and Cho E.J. Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice. J. Pharm. Pharmacol. 56 (2004) 107-113
    • (2004) J. Pharm. Pharmacol. , vol.56 , pp. 107-113
    • Yokozawa, T.1    Satoh, A.2    Cho, E.J.3
  • 82


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