Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway

Cancer Letters

Volumn 320, Issue 1, 2012, Pages 96-103

  Jiao, Jianhua ^a   Hong, Shanchao ^a   Zhang, Jin ^a   Ma, Lei ^a   Sun, Yan ^a   Zhang, Donghui ^a   Shen, Bo ^a   Zhu, Changliang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Chemoresistance; Hepatocellular carcinoma cell; OPN3

Indexed keywords

FLUOROURACIL; OPSIN; OPSIN3; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ADVANCED CANCER; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL STRAIN HEPG2; CHINA; CONTROLLED STUDY; GENE EXPRESSION; GENE REPLICATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; ROD OPSINS; TRANSFECTION;

EID: 84862826377     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.01.035     Document Type: Article

References (36)

1. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55:74-108.
2. Takayama T., Makuuchi M., Hasegawa K. Single HCC smaller than 2cm: surgery or ablation?: surgeon's perspective. J. Hepatobiliary Pancreat Sci. 2010, 17:422-424.
3. Simonetti R.G., Liberati A., Angiolini C., Pagliaro L. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann. Oncol. 1997, 8:117-136.
4. Ikeda M., Okusaka T., Ueno H., Morizane C., Kojima Y., Iwasa S., Hagihara A. Predictive factors of outcome and tumor response to systemic chemotherapy in patients with metastatic hepatocellular carcinoma. Jpn. J. Clin. Oncol. 2008, 38:675-682.
5. Jassem J. Chemotherapy of advanced non-small cell lung cancer. Ann. Oncol. 1999, 10(6):77-82.
6. Cascinu S., Graziano F., Catalano G. Chemotherapy for advanced pancreatic cancer: it may no longer be ignored. Ann. Oncol. 1999, 10:105-109.
7. Ramalingam S., Belani C. Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions. Oncologist 2008, 13(1):5-13.
8. Moertel C.G. Chemotherapy of gastrointestinal cancer. New Engl. J. Med. 1978, 299:1049-1052.
9. Pinedo H.M., Peters G.F. Fluorouracil: biochemistry and pharmacology. J. Clin. Oncol. 1988, 6:1653-1664.
10. Mukai M., Sato S., Tajima T., Ninomiya H., Wakui K., Komatsu N., Tsuchiya K., Nakasaki H., Makuuchi H. Recurrence and 5-FU sensitivity of stage I/II node-negative breast, lung, or gastric cancer with occult neoplastic cells in lymph node sinuses. Oncol. Rep. 2006, 15:815-820.
11. Lin D.Y., Lin S.M., Liaw Y.F. Non-surgical treatment of hepatocellular carcinoma. J. Gastroenterol. Hepatol. 1997, 12:S319-S328.
12. Jin J., Huang M., Wei H.L., Liu G.T. Mechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402). World J. Gastroenterol. 2002, 8:1029-1034.
13. Blackshaw S., Snyder S.H. Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. J. Neurosci. 1999, 19:3681-3690.
14. Halford S., Freedman M.S., Bellingham J., Inglis S.L., Poopalasundaram S., Soni B.G., Foster R.G., Hunt D.M. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. Genomics 2001, 72:203-208.
15. Shen W.L., Kwon Y., Adegbola A.A., Luo J., Chess A., Montell C. Function of rhodopsin in temperature discrimination in Drosophila. Science 2011, 331:1333-1336.
16. White J.H., Chiano M., Wigglesworth M., Geske R., Riley J., White N., Hall S., Zhu G., Maurio F., Savage T., Anderson W., Cordy J., Ducceschi M., Vestbo J., Pillai S.G. Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation. Hum. Mol. Genet. 2008, 17:1890-1903.
17. Peters G.J., Backus H.H., Freemantle S., van Triest B., Codacci-Pisanelli G., van der Wilt C.L., Smid K., Lunec J., Calvert A.H., Marsh S., McLeod H.L., Bloemena E., Meijer S., Jansen G., van Groeningen C.J., Pinedo H.M. Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochim. Biophys. Acta 2002, 1587:194-205.
18. Wang W., Cassidy J., O'Brien V., Ryan K.M., Collie-Duguid E. Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 2004, 64:8167-8176.
19. Metzger R., Danenberg K., Leichman C.G., Salonga D., Schwartz E.L., Wadler S., Lenz H.J., Groshen S., Leichman L., Danenberg P.V. High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. Clin. Cancer Res. 1998, 4:2371-2376.
20. Ikeguchi M., Hirooka Y., Makino M., Kaibara N. Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine. Oncol. Rep. 2001, 8:621-625.
21. Moutsaki P., Whitmore D., Bellingham J., Sakamoto K., David-Gray Z.K., Foster R.G. Teleost multiple tissue (tmt) opsin: a candidate photopigment regulating the peripheral clocks of zebrafish?. Brain Res. Mol. Brain Res. 2003, 112:135-145.
22. Elmore S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35:495-516.
23. Chu E.W., Malmgren R.A. An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons. Cancer Res. 1965, 25:884-895.
24. Zile M.H., Cullum M.E., Roltsch I.A., DeHoog J.V., Welsch C.W. Effect of moderate vitamin A supplementation and lack of dietary vitamin A on the development of mammary tumors in female rats treated with low carcinogenic dose levels of 7,12-dimethylbenz(a)anthracene. Cancer Res. 1986, 46:3495-3503.
25. Masui F., Matsuda M., Akazome Y., Imaoka T., Mori T. Prevention of neonatal estrogen imprinting by vitamin A as indicated by estrogen receptor expression in the mouse vagina. Cell Tissue. Res. 2001, 306:441-447.
26. Park S.H., Lim J.S., Jang K.L. All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27. Cancer Lett. 2011, 310:232-239.
27. Higginbotham K.B., Lozano R., Brown T., Patt Y.Z., Arima T., Abbruzzese J.L., Thomas M.B. A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2008, 134:1325-1335.
28. Shichida Y., Matsuyama T. Evolution of opsins and phototransduction. Philos Trans. R Soc. Lond B Biol. Sci. 2009, 364:2881-2895.
29. Lappano R., Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat. Rev. Drug Discov. 2011, 10:47-60.
30. Yoo B.C., Jeon E., Hong S.H., Shin Y.K., Chang H.J., Park J.G. Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line. Clin. Cancer Res. 2004, 10:4176-4184.
31. Aziz M.H., Nihal M., Fu V.X., Jarrard D.F., Ahmad N. Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl2 family proteins. Mol. Cancer Ther. 2006, 5:1335-1341.
32. Yang E., Korsmeyer S.J. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 1996, 88:386-401.
33. Chen K.F., Yeh P.Y., Yeh K.H., Lu Y.S., Huang S.Y., Cheng A.L. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res. 2008, 68:6698-6707.
34. You F., Aoki K., Ito Y., Nakashima S. AKT plays a pivotal role in the acquisition of resistance to 5-fluorouracil in human squamous carcinoma cells. Mol. Med. Report 2009, 2:609-613.
35. Shin J.Y., Kim J.O., Lee S.K., Chae H.S., Kang J.H. LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. BMC Cancer 2010, 10:425.
36. Violette S., Poulain L., Dussaulx E., Pepin D., Faussat A.M., Chambaz J., Lacorte J.M., Staedel C., Lesuffleur T. Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl2 and Bcl-X(L) in addition to Bax and p53 status. Int. J. Cancer 2002, 98:498-504.