Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy

Journal of Ethnopharmacology

Volumn 141, Issue 1, 2012, Pages 111-118

  Zhang, Mianzhi ^a   Liu, Miao ^a   Xiong, Min ^b   Gong, Junbo ^c   Tan, Xiaoyue ^b  

^a Nephrology Division   (China)

^b NANKAI UNIVERSITY   (China)

^c TianjinUniversity   (China)

Author keywords

Diabetic nephropathy; Epithelial to mesenchymal transition; Glomerulosclerosis; Podocyte; Schisandra chinensis

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; MESSENGER RNA; METHENAMINE; NEPHRIN; PERIODIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; SCHISANDRA CHINENSIS EXTRACT; UVOMORULIN;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL CULTURE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; EXTRACELLULAR MATRIX; FRUIT; GLOMERULOSCLEROSIS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PODOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SNAIL; STAINING; STREPTOZOCIN DIABETES; TRICHOME; URINARY EXCRETION; URINE LEVEL; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ALBUMINURIA; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; EPITHELIAL-MESENCHYMAL TRANSITION; FRUIT; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PODOCYTES; PROTECTIVE AGENTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHISANDRA; TIME FACTORS;

GASTROPODA; MUS; SCHISANDRA CHINENSIS;

EID: 84862826094     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.02.007     Document Type: Article

References (33)

1. C.F. Chien, Y.T. Wu, and T.H. Tsai Biological analysis of herbal medicines used for the treatment of liver diseases Biomedical Chromatography 25 2011 21 38
2. P.Y. Chiu, H.Y. Leung, and K.M. Ko Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats Biological & Pharmaceutical Bulletin 31 2008 602 605
3. P.Y. Chiu, H.Y. Leung, A.H. Siu, M.K. Poon, and K.M. Ko Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts Acta Pharmacologica Sinica 28 2007 1559 1565
4. P.Y. Chiu, M.H. Tang, D.H. Mak, M.K. Poon, and K.M. Ko Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins Free Radical Biology & Medicine 35 2003 368 380
5. A. Dixon, and C. Maric 17beta-Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factor-beta protein expression and signaling American Journal of Physiology. Renal Physiology 293 2007 F1678 F1690
6. R.V. Durvasula, and S.J. Shankland Podocyte injury and targeting therapy: an update Current Opinion in Nephrology and Hypertension 15 2006 1 7
7. V.V. Giridharan, R.A. Thandavarayan, S. Sato, K.M. Ko, and T. Konishi Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice Free Radical Biology & Medicine 45 2011 950 958
8. S.P. Gray, and M.E. Cooper Diabetic nephropathy in 2010: alleviating the burden of diabetic nephropathy Nature Review Nephrology 7 2011 71 73
9. A. Hartner, N. Cordasic, C. Menendez-Castro, G. Volkert, J.M. Yabu, M. Kupraszewicz-Hutzler, W. Rascher, and K.F. Hilgers Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy American Journal of Physiology. Renal Physiology 299 2010 F1151 F1157
10. G. Jarad, and J.H. Miner Update on the glomerular filtration barrier Current Opinion in Nephrology and Hypertension 18 2009 226 232
11. Y.S. Kang, Y. Li, C. Dai, L.P. Kiss, C. Wu, and Y. Liu Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria Kidney International 78 2010 363 373
12. T. Kanjanabuch, L.J. Ma, J. Chen, A. Pozzi, Y. Guan, P. Mundel, and A.B. Fogo PPAR-gamma agonist protects podocytes from injury Kidney International 71 2007 1232 1239
13. J. Karalliedde, and G. Viberti Proteinuria in diabetes: bystander or pathway to cardiorenal disease? Journal of the American Society of Nephrology 21 2010 2020 2027
14. D. Kerjaschki Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis Journal of Clinical Investigation 108 2001 1583 1587
15. H.J. Kim, M.S. Oh, J. Hong, and Y.P. Jang Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS Phytochemical Analysis 22 2011 258 262
16. T. Konishi Brain oxidative stress as basic target of antioxidant traditional oriental medicines Neurochemical Research 34 2009 711 716
17. D.Y. Kwon, S. Kim da, H.J. Yang, and S. Park The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-gamma pathways in in vitro and in vivo studies Journal of Ethnopharmacology 135 2011 455 462
18. Y. Liu New insights into epithelial-mesenchymal transition in kidney fibrosis Journal of the American Society of Nephrology 21 2010 212 222
19. Y. Lu, and D.F. Chen Analysis of Schisandra chinensis and Schisandra sphenanthera Journal of Chromatography A 1216 2009 1980 1990
20. A.K. Mandal, and L.M. Hiebert Renal protection in diabetes: is it affected by glucose control or inhibition of the renin-angiotensin pathway? Clinical Nephrology 69 2008 169 178
21. R.W. Mankhey, F. Bhatti, and C. Maric 17beta-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy American Journal of Physiology. Renal Physiology 288 2005 F399 F405
22. R.M. Mason, and N.A. Wahab Extracellular matrix metabolism in diabetic nephropathy Journal of the American Society of Nephrology 14 2003 1358 1373
23. G. Moreno-Bueno, F. Portillo, and A. Cano Transcriptional regulation of cell polarity in EMT and cancer Oncogene 27 2008 6958 6969
24. T. Ninomiya, V. Perkovic, B.E. de Galan, S. Zoungas, A. Pillai, M. Jardine, A. Patel, A. Cass, B. Neal, N. Poulter, C.E. Mogensen, M. Cooper, M. Marre, B. Williams, P. Hamet, G. Mancia, M. Woodward, S. Macmahon, and J. Chalmers Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes Journal of the American Society of Nephrology 20 2009 1813 1821
25. S.Y. Oh, Y.H. Kim, D.S. Bae, B.H. Um, C.H. Pan, C.Y. Kim, H.J. Lee, and J.K. Lee Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Bioscience Biotechnology and Biochemistry 74 2010 285 291
26. M.E. Pagtalunan, P.L. Miller, S. Jumping-Eagle, R.G. Nelson, B.D. Myers, H.G. Rennke, N.S. Coplon, L. Sun, and T.W. Meyer Podocyte loss and progressive glomerular injury in type II diabetes Journal of Clinical Investigation 99 1997 342 348
27. J. Peti-Peterdi, and A. Sipos A high-powered view of the filtration barrier Journal of the American Society of Nephrology 21 2010 1835 1841
28. Y. Qian, E. Feldman, S. Pennathur, M. Kretzler, and F.C. Brosius 3rd From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy Diabetes 57 2008 1439 1445
29. T. Saito, E. Sumithran, E.F. Glasgow, and R.C. Atkins The enhancement of aminonucleoside nephrosis by the co-administration of protamine Kidney International 32 1987 691 699
30. A. Stacchiotti, G. Li Volti, A. Lavazza, I. Schena, M.F. Aleo, L.F. Rodella, and R. Rezzani Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro Toxicology 286 2011 48 57
31. G.H. Tesch, and T.J. Allen Rodent models of streptozotocin-induced diabetic nephropathy Nephrology (Carlton) 12 2007 261 266
32. B.L. Wharram, M. Goyal, J.E. Wiggins, S.K. Sanden, S. Hussain, W.E. Filipiak, T.L. Saunders, R.C. Dysko, K. Kohno, L.B. Holzman, and R.C. Wiggins Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene Journal of the American Society of Nephrology 16 2005 2941 2952
33. J. Yang, and Y. Liu Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis Journal of the American Society of Nephrology 13 2002 96 107