A high-powered view of the filtration barrier

Journal of the American Society of Nephrology

Volumn 21, Issue 11, 2010, Pages 1835-1841

  Peti Peterdi, János ^a   Sipos, Arnold ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; DEXTRAN;

ALBUMINURIA; BOWMAN CAPSULE; DIAGNOSTIC IMAGING; FOCAL GLOMERULOSCLEROSIS; GLOMERULOSCLEROSIS; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; JUXTAGLOMERULAR APPARATUS; MACROMOLECULE; MEMBRANE PERMEABILITY; MULTIPHOTON MICROSCOPY; NEPHRON; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; REVIEW;

EID: 78149355567     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010040378     Document Type: Review

References (47)

1. Denk W, Strickler J, Webb WW: Two-photon laser scanning fluorescence microscopy. Science 248: 73-76, 1990 (Pubitemid 20139273)
2. Peti-Peterdi J, Morishima S, Bell PD, Okada Y: Two-photon excitation fluorescence imaging of the living juxtaglomerular apparatus. Am J Physiol Renal Physiol 283: F197-F201, 2002 (Pubitemid 34680486)
3. Dunn KW, Sandoval RM, Kelly KJ, Dagher PC, Tanner GA, Atkinson SJ, Bacallao RL, Molitoris BA: Functional studies of the kidney of living animals using multicolor twophoton microscopy. Am J Physiol Cell Physiol 283: C905-C916, 2002
4. Peti-Peterdi J: Multiphoton imaging of renal tissues in vitro. Am J Physiol Renal Physiol 288: F1079-F1083, 2005
5. Molitoris BA, Sandoval RM: Intravital multiphoton microscopy of dynamic renal processes. Am J Physiol Renal Physiol 288: F1084-F109, 2005
6. Kang JJ, Toma I, Sipos A, McCulloch F, Peti- Peterdi J: Quantitative imaging of basic functions in renal (patho)physiology. Am J Physiol Renal Physiol 291: F495-F502, 2006 (Pubitemid 44148139)
7. Sipos A, Toma I, Kang JJ, Rosivall L, Peti-Peterdi J: Advances in renal (patho)physiology using multiphoton microscopy. Kidney Int 72: 1188-1191, 2007 (Pubitemid 350059655)
8. Peti-Peterdi J, Toma I, Sipos A, Vargas SL: Multiphoton imaging of renal regulatory mechanisms. Physiology (Bethesda) 24: 88-96, 2009
9. Schnermann J, Briggs JP: Function of the juxtaglomerular apparatus: Control of glomerular hemodynamics and renin secretion. In: The Kidney Physiology and Pathophysiology, edited by Alpern RJ and Hebert SC, London, Elsevier Academic Press, 2008, pp 589-626
10. Thomson SC, Blantz RC: Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis. J Am Soc Nephrol 19: 2272-2275, 2008
11. Peti-Peterdi J: Calcium wave of tubuloglomerular feedback. Am J Physiol Renal Physiol 291: F473-480, 2006
12. Peti-Peterdi J, Fintha A, Fuson AL, Tousson A, Chow RH: Real-time imaging of renin release in vitro. Am J Physiol Renal Physiol 287: F329-F35, 2004
13. Peti-Peterdi J, Harris RC: Macula densa sensing and signaling mechanisms of renin release.JAm Soc Nephrol 21: 1093-1096, 2010
14. Saleem MA, Zavadil J, Bailly M, McGee K, Witherden IR, Pavenstadt H, Hsu H, Sanday J, Satchell SC, Lennon R, Ni L, Bottinger EP, Mundel P, Mathieson PW: The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells. Am J Physiol Renal Physiol 295: F959-F970, 2008
15. Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB: A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804, 2005
16. Tanner GA, Rippe C, Shao Y, Evan AP, Williams JC Jr: Glomerular permeability to macromolecules in the Necturus kidney. Am J Physiol Renal Physiol 296: F1269-1278, 2009
17. Farquhar MG: The glomerular basement membrane: Not gone, just forgotten. J Clin Invest 116: 2090-2093, 2006
18. Smithies O: Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function. Proc Natl Acad Sci U S A 100: 4108-4113, 2003
19. Tryggvason K: Unraveling the mechanisms of glomerular ultrafiltration: Nephrin, a key component of the slit diaphragm. J Am Soc Nephrol 10: 2440-2445, 1999
20. Goldberg S, Adair-Kirk TL, Senior RM, Miner JH: Maintenance of glomerular filtration barrier integrity requires laminin alpha5. J Am Soc Nephrol 21: 579-586, 2010
21. Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB, Miner JH, Roopenian DC, Unanue ER, Shaw AS: Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A 105: 967-972, 2008
22. Neal CR, Crook H, Bell E, Harper SJ, Bates DO: Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space. J Am Soc Nephrol 16: 1223-1235, 2005 (Pubitemid 41716507)
23. Salmon AH, Toma I, Sipos A, Muston PR, Harper SJ, Bates DO, Neal CR, Peti-Peterdi J: Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space. Am J Physiol Renal Physiol 293: F1777-F1786, 2007
24. Holstein-Rathlou N-H, Leyssac PP: TGF-mediated oscillations in proximal intratubular pressure: Differences between spontaneously hypertensive rats and Wistar-Kyoto rats. Acta Physiol Scand 126: 333-339, 1986
25. Marsh DJ, Sosnovtseva OV, Chon KH, Holstein-Rathlou NH: Nonlinear interactions in renal blood flow regulation. Am J Physiol Regul Integr Comp Physiol 288: R1143-R1159, 2005 (Pubitemid 40593697)
26. Rosivall L, Mirzahosseini S, Toma I, Sipos A, Peti-Peterdi J: Fluid flow in the juxtaglomerular interstitium visualized in vivo. Am J Physiol Renal Physiol 291: F1241-F1247, 2006 (Pubitemid 44887237)
27. Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD: The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states. Kidney Int 71: 504-513, 2007
28. Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D: Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J Am Soc Nephrol 20: 489-494, 2009
29. Tojo A, Endou H: Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol 263: F601-F606, 1992
30. Lazzara MJ, Deen WM: Model of albumin reabsorption in the proximal tubule. Am J Physiol Renal Physiol 292: F430-F439, 2007
31. Christensen EI, Birn H, Rippe B, Maunsbach AB: Controversies in nephrology: Renal albumin handling, facts, and artifacts! Kidney Int 72: 1192-1194, 2007
32. Comper WD, Haraldsson B, Deen WM: Resolved: Normal glomeruli filter nephrotic levels of albumin. J Am Soc Nephrol 19: 427-432, 2008 (Pubitemid 351355385)
33. Gekle M: Renal albumin handling: A look at the dark side of the filter. Kidney Int 71: 479-481, 2007
34. Remuzzi A, Sangalli F, Fassi A, Remuzzi G: Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique [Letter]. Kidney Int 72: 1410-1411, 2007 (Pubitemid 350126769)
35. Tanner GA: Glomerular sieving coefficient of serum albumin in the rat: A two-photon microscopy study. Am J Physiol Renal Physiol 296: F1258-F1265, 2009
36. Peti-Peterdi J: Independent two-photon measurements of albumin GSC give low values. Am J Physiol Renal Physiol 296: F1255-F1257, 2009
37. Theer P, Denk W: On the fundamental imaging- depth limit in two-photon microscopy. J Opt Soc Am A Opt Image Sci Vis 23: 3139-3149, 2006 (Pubitemid 46023808)
38. Haiss F, Jolivet R, Wyss MT, Reichold J, Braham NB, Scheffold F, Krafft MP, Weber B: Improved in vivo two-photon imaging after blood replacement by perfluorocarbon. J Physiol 587: 3153-3158, 2009
39. Kim YH, Goyal M, Kurnit D, Wharram B, Wiggins J, Holzman L, Kershaw D, Wiggins R: Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 60: 957-968, 2001 (Pubitemid 34205795)
40. Eyre J, Ioannou K, Grubb BD, Saleem MA, Mathieson PW, Brunskill NJ, Christensen EI, Topham PS: Statin-sensitive endocytosis of albumin by glomerular podocytes. Am J Physiol Renal Physiol 292: F674-F681, 2007 (Pubitemid 46220536)
41. Mundel P, Reiser J: Proteinuria: an enzymatic disease of the podocyte? Kidney Int 77: 571-580, 2010
42. Yoshikawa N, Ito H, Akamatsu R, Hazikano H, Okada S, Matsuo T: Glomerular podocyte vacuolation in focal segmental glomerulosclerosis. Arch Pathol Lab Med 110: 394-398, 1986 (Pubitemid 16104271)
43. Gassler N, Elger M, Kränzlin B, Kriz W, Gretz N, Hähnel B, Hosser H, Hartmann I: Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat. Kidney Int 60: 106-116, 2001
44. Fissell WH, Hofmann CL, Ferrell N, Schnell L, Dubnisheva A, Zydney AL, Yurchenco PD, Roy S: Solute partitioning and filtration by extracellular matrices. Am J Physiol Renal Physiol 297: F1092-F1100, 2009
45. Ohse T, Chang AM, Pippin JW, Jarad G, Hudkins KL, Alpers CE, Miner JH, Shankland SJ: A new function for parietal epithelial cells: A second glomerular barrier. Am J Physiol Renal Physiol 297: F1566-F1574, 2009
46. Ohse T, Pippin JW, Chang AM, Krofft RD, Miner JH, Vaughan MR, Shankland SJ: The enigmatic parietal epithelial cell is finally getting noticed: A review. Kidney Int 76: 1225-1238, 2009
47. Ronconi E, Sagrinati C, Angelotti ML, Lazzeri E, Mazzinghi B, Ballerini L, Parente E, Becherucci F, Gacci M, Carini M, Maggi E, Serio M, Vannelli GB, Lasagni L, Romagnani S, Romagnani P: Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 20: 322-332, 2009