Immunogenicity Study of Plasmid DNA Encoding Mouse Cysteine-Rich Secretory Protein-1 (mCRISP1) as a Contraceptive Vaccine

American Journal of Reproductive Immunology

Volumn 68, Issue 1, 2012, Pages 47-55

  Luo, Jin ^a   Yang, Jing ^a   Cheng, Yan ^a   Li, Wei ^a   Yin, Tai Lang ^a   Xu, Wang Ming ^a   Zou, Yu Jie ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

CRISP 1; DNA vaccine; Fertility; Immunocontraception

Indexed keywords

CONTRACEPTIVE VACCINE; MOUSE CYSTEINE RICH SECRETORY PROTEIN 1; PLASMID DNA; PROTEIN ANTIBODY; RECOMBINANT MOUSE CYSTEINE RICH SECRETORY PROTEIN 1; RECOMBINANT PROTEIN; SECRETORY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FERTILITY; FERTILIZATION IN VITRO; HISTOLOGY; IMMUNE RESPONSE; IMMUNOCONTRACEPTION; IMMUNOFLUORESCENCE; IMMUNOGENICITY; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; LITTER SIZE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOZOON PENETRATION; WESTERN BLOTTING;

ANIMALS; AUTOANTIBODIES; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; PLASMIDS; VACCINES, CONTRACEPTIVE; VACCINES, DNA;

EID: 84862825529     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2012.01117.x     Document Type: Article

References (31)

1. Naz RK, Gupta SK, Gupta JC, Vyas HK, Talwar GP: Recent advances in contraceptive vaccine development: a mini-review. Hum Reprod 2005; 20:3271-3283.
2. Finer LB, Henshaw SK: Disparities in rates of unintended pregnancy in the United States, 1994 and 2001. Perspect Sex Reprod Health 2006; 38:90-96.
3. Ellerman DA, Busso D, Maldera JA, Cuasnicú PS: Immunocontraceptive properties of recombinant sperm protein DE: implications for the development of novel contraceptives. Fertil Steril 2008; 89:199-205.
4. Naz RK: Vaccine for contraception targeting sperm. Immunol Rev 1999; 171:193-202.
5. Naz RK: Antisperm contraceptive vaccines: where we are and where we are going? Am J Reprod Immunol 2011; 66:5-12.
6. Cameo MS, Blaquier JA: Androgen-controlled specific proteins in rat epididymis. J Endocr 1976; 69:317-324.
7. Kohane AC, Cameo MS, Piñeiro L, Garberi JC, Blaquier JA: Distribution and site of production of specific proteins in the rat epididymis. Biol Reprod 1980; 23:181-187.
8. Kohane AC, González Echeverría FM, Piñeiro L, Blaquier JA: Interaction of proteins of epididymal origin with spermatozoa. Biol Reprod 1980; 23:737-742.
9. Rochwerger L, Cohen DJ, Cuasnicu PS: Mammalian sperm-egg fusion: the rat egg has complementary sites for a sperm protein that mediates gamete fusion. Dev Biol 1992; 153:83-90.
10. Perez Martinez S, Conesa D, Cuasnicu PS: Potential contraceptive use of epididymal proteins: evidence for the participation of specific antibodies against rat epididymal protein DE in male and female fertility inhibition. J Reprod Immunol 1995; 29:31-45.
11. Ellerman DA, Brantua VS, Martinez SP, Cohen DJ, Conesa D, Cuasnicu PS: Potential contraceptive use of epididymal proteins: immunization of male rats with epididymal protein DE inhibits sperm fusion ability. Biol Reprod 1998; 59:1029-1036.
12. Cohen DJ, Ellerman DA, Cuasnicú PS: Mammalian sperm-egg fusion: Evidence that epididymal protein DE plays a role in mouse gamete Fusion. Biol Reprod 2000; 63:462-468.
13. Ellerman DA, Cohen DJ, Weigel Muñoz M, Da Ros VG, Ernesto JI, Tollner TL, et al.: Immunologic behavior of human cysteine-rich secretory protein 1 (hCRISP1) in primates: prospects for immunocontraception. Fertil Steril 2010; 93:2551-2556.
14. Cohena AD, Boyer JD, Weiner DB: Modulating the immune response to genetic immunization. FASEB J 1998; 12:1611-1626.
15. Naz RK: Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice. Mol Reprod Dev 2006; 73:1473-1479.
16. Naz RK: Effect of sperm DNA vaccine on fertility of female mice. Mol Reprod Dev 2006; 73:918-928.
17. Chen Y, Zhang D, Xin N, Xiong Y, Chen P, Li B, Tu X, Lan F: Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immunocontraceptive effect on mice. Sci China C Life Sci 2008; 51:308-316.
18. Sun J, Xia HF, Yang Y, Peng JP: The antifertility effects of DNA vaccine-induced immune responses against uroguanylin. Vaccine 2008; 26:3696-3704.
19. An G, Huang TH, Wang DG, Xie QD, Ma L, Chen DY: In vitro and in vivo studies evaluating recombinant plasmid pCXN2-mIzumo as a potential immunocontraceptive antigen. Am J Reprod Immunol 2009; 61:227-235.
20. Sun Z, Jin F, Li Y, Zhang J: Immunocontraceptive effect of DNA vaccine targeting fertilin beta in male mice. Am J Reprod Immunol 2010; 63:282-290.
21. Yu MF, Fang WN, Xiong GF, Yang Y, Peng JP: Evidence for the inhibition of fertilization in vitro by anti-ZP3 antisera derived from DNA vaccine. Vaccine 2011; 29:4933-4939.
22. Luo J, Yang J, Xu WM, Yin TL: Construction of recombinant plasmid of mouse cysteine-rich secretory protein-1 and Its expression in COS-7 Cells. Reprod Contracep 2010; 8:509-513.
23. Jagadish N, Rana R, Mishra D, Garg M, Selvi R, Suri A: Characterization of immune response in mice to plasmid DNA encoding human sperm associated antigen 9 (SPAG9). Vaccine 2006; 24:3695-3703.
24. Yanagimachi R: Zona-free hamster eggs: their use in assessing fertilizing capacity and examining chromosomes of human spermatozoa. Gamete Res 1984; 10:187-232.
25. Dubé E, Legaré C, Gaudreault C, Sullivan R: Contraceptive responses of female hamsters immunized with recombinant sperm protein P26h. Contraception 2005; 72:459-467.
26. Calvo PA, Daly TM, Long CA: Plasmodium yoelii: the role of the individual epidermal growth factor-like domains of the merozoite surface protein-1 in protection from malaria. Exp Parasitol 1996; 82:54-64.
27. Ling IT, Ogun SA, Holder AA: The combined epidermal growth factor-like modules of Plasmodium yoelii merozoite surface protein-1 are required for a protective immune responses to the parasite. Parasite Immunol 1995; 17:425-433.
28. Ryuko K, Schol DJ, Snijdewint FG, von Mensdorff-Pouilly S, Poort-Keesom RJ, Karuntu-Wanamarta YA, et al.: Characterization of a new MUC1 monoclonal antibody (vu-2-g7) directed to the glycosylated PDTR sequence of MUC1. Tumor Biol 2000; 21:197-210.
29. Sakurai H, Williamson RA, Crow JE, Beeler JA, Poignard P, Bastidas RB, et al.: Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines. J Virol 1999; 73:2956-2962.
30. Cohen DJ, Ellerman DA, Busso D, Morgenfeld MM, Piazza AD, Hayashi M, et al.: Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg. Biol Reprod 2001; 65:1000-1005.
31. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, et al.: Direct gene transfer into mouse muscle in vivo. Science 1990; 247:1465-1468.