Inhibition of hepatitis B Virus replication by hepatocyte nuclear factor 4-alpha specific short hairpin RNA

Liver International

Volumn 32, Issue 5, 2012, Pages 742-751

  He, Fang ^a,b   Chen, En Qiang ^a,b   Liu, Li ^a,b   Zhou, Tao You ^a,b   Liu, Cong ^a,b   Cheng, Xing ^a,b   Liu, Feng Jun ^a,b   Tang, Hong ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Hepatitis B virus; Hepatocyte nuclear factor 4 ; Replication; RNA interference; Transcription

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; SHORT HAIRPIN RNA; VIRUS RNA;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; DNA REPLICATION; GENE EXPRESSION; GENE SILENCING; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PROTEIN EXPRESSION; RNA INTERFERENCE; SOUTHERN BLOTTING; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, VIRAL; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; LIVER; MICE; RNA INTERFERENCE; RNA, SMALL INTERFERING; VIRUS REPLICATION;

EID: 84862820756     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02748.x     Document Type: Article

References (50)

1. Williams R. Global challenges in liver disease. Hepatology 2006; 44: 521-6.
2. McMahon BJ. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005; 25(Suppl. 1): 3-8.
3. Ganem D, Prince AM. Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 2004; 350: 1118-29.
4. Wu CF, Yu MW, Lin CL, et al. Long-term tracking of hepatitis B viral load and the relationship with risk for hepatocellular carcinoma in men. Carcinogenesis 2008; 29: 106-12.
5. Chan HL, Tse CH, Mo F, et al. High viral load and hepatitis B virus subgenotype Ce are associated with increased risk of hepatocellular carcinoma. J Clin Oncol 2008; 26: 177-82.
6. Iloeje UH, Yang HI, Su J, et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678-86.
7. Chen G, Lin W, Shen F, et al. Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. Am J Gastroenterol 2006; 101: 1797-803.
8. Schiff ER, Sorrell MF, Maddrey WC. Schiff's Diseases of the Liver Volume 1, 8th edn. Philadelphia: Lippincott-Raven Publishers, 1999.
9. Papatheodoridis GV, Dimou E, Papadimitropoulos V. Nucleoside analogues for chronic hepatitis B: antiviral efficacy and viral resistance. Am J Gastroenterol 2002; 97: 1618-28.
10. Thomas HC. Best practice in the treatment of chronic hepatitis B: a summary of the European viral hepatitis educational initiative (EVHEI). J Hepatol 2007; 47: 588-97.
11. Craxi A, Antonucci G, Camma C. Treatment options in HBV. J Hepatol 2006; 44: S77-83.
12. Liaw YF. Hepatitis B virus replication and liver disease progression: the impact of antiviral therapy. Antivir Ther 2006; 11: 669-79.
13. Tang H, Banks KE, Anderson AL, McLachlan A. Hepatitis B virus transcription and replication. Drug News Perspect 2001; 14: 325-34.
14. Tang H, McLachlan A. Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism. Proc Natl Acad Sci USA 2001; 98: 1841-6.
15. Oropeza CE, Li L, McLachlan A. Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner. J Virol 2008; 82: 3814-21.
16. Tang H, McLachlan A. Mechanisms of inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by hepatocyte nuclear factor 3beta. J Virol 2002; 76: 8572-81.
17. Tang H, McLachlan A. Avian and Mammalian hepadnaviruses have distinct transcription factor requirements for viral replication. J Virol 2002; 76: 7468-72.
18. Tang H, Raney AK, McLachlan A. Replication of the wild type and a natural hepatitis B virus nucleocapsid promoter variant is differentially regulated by nuclear hormone receptors in cell culture. J Virol 2001; 75: 8937-48.
19. Yu X, Mertz JE. Critical roles of nuclear receptor response elements in replication of hepatitis B virus. J Virol 2001; 75: 11354-64.
20. Zheng Y, Li J, Ou JH. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J Virol 2004; 78: 6908-14.
21. Yu X, Mertz JE. Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1. J Virol 2003; 77: 2489-99.
22. Yu X, Mertz JE. Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily. J Virol 1997; 71: 9366-74.
23. Raney AK, Johnson JL, Palmer CN, McLachlan A. Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter. J Virol 1997; 71: 1058-71.
24. Huan B, Kosovsky MJ, Siddiqui A. Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor. J Virol 1995; 69: 547-51.
25. Garcia AD, Ostapchuk P, Hearing P. Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I. J Virol 1993; 67: 3940-50.
26. Sladek FM, Zhong WM, Lai E, Darnell JE Jr. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 1990; 4: 2353-65.
27. Li L, Oropeza CE, Sainz BJr, et al. Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. PLoS ONE 2009; 4: e5489.
28. Chen WS, Manova K, Weinstein DC, et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 1994; 8: 2466-77.
29. Neilson JR, Sharp PA. Small RNA regulators of gene expression. Cell 2008; 134: 899-902.
30. Stevenson M. Therapeutic potential of RNA interference. N Engl J Med 2004; 351: 1772-7.
31. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296: 550-3.
32. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-11.
33. Rauschhuber C, Xu H, Salazar FH, Marion PL, Ehrhardt A. Exploring gene-deleted adenoviral vectors for delivery of short hairpin RNAs and reduction of hepatitis B virus infection in mice. J Gene Med 2008; 10: 878-89.
34. Chen Y, Cheng G, Mahato RI. RNAi for treating hepatitis B viral infection. Pharm Res 2008; 25: 72-86.
35. Wen WH, Liu JY, Qin WJ, et al. Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery. Hepatology 2007; 46: 84-94.
36. Weinberg MS, Ely A, Barichievy S, et al. Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA. Mol Ther 2007; 15: 534-41.
37. Carmona S, Ely A, Crowther C, et al. Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs. Mol Ther 2006; 13: 411-21.
38. Liu FJ, Liu L, He F, et al. Establishment and primary application of a mouse model with hepatitis B virus replication. World J Gastroenterol 2007; 13: 5324-30.
39. Yang PL, Althage A, Chung J, Chisari FV. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 2002; 99: 13825-30.
40. Tang H, Delgermaa L, Huang F, et al. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J Virol 2005; 79: 5548-56.
41. Long Y, Chen E, Liu C, et al. The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients. J Viral Hepat 2009; 16: 537-46.
42. Axiotis CA, Monteagudo C, Merino MJ, LaPorte N, Neumann RD. Immunohistochemical detection of P-glycoprotein in endometrial adenocarcinoma. Am J Pathol 1991; 138: 799-806.
43. Blum HE, Galun E, Liang TJ, von Weizsacker F, Wands JR. Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J Virol 1991; 65: 1836-42.
44. Yokosuka O, Arai M. Molecular biology of hepatitis B virus: effect of nucleotide substitutions on the clinical features of chronic hepatitis B. Med Mol Morphol 2006; 39: 113-20.
45. Sohn SY, Kim SB, Kim J, Ahn BY. Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins. J Gen Virol 2006; 87: 1883-91.
46. Bonino F, Ponzetto A, Veglio V, et al. The immunological diagnosis of HBsAg liver disease by combined screening for the e system in the serum and the HB core and surface antigens in liver biopsy samples. Ric Clin Lab 1977; 7: 365-72.
47. Song XQ, Chen EQ, Wang YB, et al. Construction of a plasmid vector for liver-specific inhibition of hepatocyte nuclear factor 4 alpha expression. Plasmid 2012; 67: 60-6.
48. Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 2001; 21: 1393-403.
49. Wang Z, Bishop EP, Burke PA. Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4alpha. BMC Genomics 2011; 12: 128.
50. Stanulovic VS, Kyrmizi I, Kruithof-de Julio M, et al. Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes. Hepatology 2007; 45: 433-44.