Construction of a plasmid vector for liver-specific inhibition of hepatocyte nuclear factor 4 alpha expression

Plasmid

Volumn 67, Issue 1, 2012, Pages 60-66

  Song, Xue Qin ^a,b   Chen, En Qiang ^a,b   Wang, Yue Bin ^a,b   Zhou, Tao You ^a,b   Liu, Li ^a,b   Liu, Cong ^a,b   Cheng, Xing ^a,b   Tang, Hong ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Hepatocyte nuclear factor 4 alpha; Liver specific; Short hairpin RNA

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; PLASMID VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA HAIRPIN; ENHANCER REGION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REGULATORY SEQUENCE;

ALBUMINS; ALPHA-FETOPROTEINS; ANIMALS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; LIVER; MALE; MICE; MICE, INBRED BALB C; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

MUS;

EID: 83555174571     PISSN: 0147619X     EISSN: 10959890     Source Type: Journal    
DOI: 10.1016/j.plasmid.2011.08.001     Document Type: Article

References (25)

1. Chen E.Q., et al. Construction of a highly-active, liver-specific transcriptional regulatory element through combination of the albumin promoter and alpha-fetoprotein enhancer. Plasmid 2011, 65:125-131.
2. Chen W.S., et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, le ads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994, 8:2466-2477.
3. Cheung C., et al. Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice. Biochem. Pharmacol. 2003, 66:2011-2020.
4. Costa R.H., et al. Transcription factors in liver development, differentiation, and regeneration. Hepatology 2003, 38:1331-1347.
5. Guo H., et al. Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. Am. J. Physiol. Cell Physiol. 2003, 284:C1090-C1099.
6. Hanniman E.A., et al. Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. J. Lipid Res. 2006, 47:2503-2514.
7. Herweijer H., et al. Time course of gene expression after plasmid DNA gene transfer to the liver. J. Gene Med. 2001, 3:280-291.
8. Inoue Y., et al. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J. Lipid Res. 2006, 47:215-227.
9. Jin J.R., et al. Enhancer sharing in a plasmid model containing the alpha-fetoprotein and albumin promoters. DNA Cell Biol. 1995, 14:267-272.
10. Karagiannis T.C., El-Osta A. RNA interference and potential therapeutic applications of short interfering RNAs. Cancer Gene Ther. 2005, 12:787-795.
11. Lam P.Y., et al. An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas. Mol. Ther. 2007, 15:1129-1136.
12. Lazarevich N.L., et al. Deregulation of hepatocyte nuclear factor 4 (HNF4)as a marker of epithelial tumors progression. Exp. Oncol. 2010, 32:167-171.
13. Li X., et al. Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway. Biochem. J. 2002, 368:203-211.
14. Long Y., et al. Expression of hepatocyte nuclear factor 4α and 3β in human tissues. Shijie Huaren Xiaohua Zazhi 2006, 14:2504-2509.
15. Milhavet O., et al. RNA interference in biology and medicine. Pharmacol. Rev. 2003, 55:629-648.
16. Miura A., et al. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J. Biol. Chem. 2006, 281:5246-5257.
17. Parviz F., et al. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat. Genet. 2003, 34:292-296.
18. Ren X., et al. Construction, modification and evaluation of apolipoprotein A-I promoter-driven shRNA expression vectors against hTERT. Plasmid 2011, 65:42-50.
19. Tang H., et al. Hepatitis B virus transcription and replication. Drug News Perspect. 2001, 14:325-334.
20. Tang H., et al. Replication of the wild type and a natural hepatitis B virus nucleocapsid promoter variant is differentially regulated by nuclear hormone receptors in cell culture. J. Virol. 2001, 75:8937-8948.
21. Vacher J., Tilghman S.M. Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver. Science 1990, 250:1732-1735.
22. Wang Z., et al. Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4alpha. BMC Genom. 2011, 12:128.
23. Watt A.J., et al. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 2003, 37:1249-1253.
24. Wen P., et al. Enhancer, repressor, and promoter specificities combine to regulate the rat alpha-fetoprotein gene. DNA Cell Biol. 1991, 10:525-536.
25. Wooddell C.I., et al. Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery. J. Gene Med. 2008, 10:551-563.