Physical characterization and osteogenic activity of the quaternized chitosan-loaded PMMA bone cement

Acta Biomaterialia

Volumn 8, Issue 6, 2012, Pages 2166-2174

  Tan, Honglue ^a,b   Guo, Shengrong ^a   Yang, Shengbing ^c   Xu, Xiaofen ^a   Tang, Tingting ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

^c East China University of Science and Technology   (China)

Author keywords

Hydroxypropyltrimethyl ammonium chloride chitosan; Osteogenic activity; Physical properties; PMMA bone cement

Indexed keywords

ANTIBIOTICS; APATITE; ARTHROPLASTY; BONE; BONE CEMENT; CELL CULTURE; CELL PROLIFERATION; CHITOSAN; GENE EXPRESSION; HYDROPHILICITY; ORTHOPEDICS; STEM CELLS;

AMMONIUM CHLORIDE; ANTIBIOTIC-RESISTANT BACTERIA; APATITE FORMATION; HYDROXYPROPYLTRIMETHYL AMMONIUM CHLORIDE CHITOSAN; OSTEOGENIC ACTIVITY; OSTEOINTEGRATION; PHYSICAL CHARACTERIZATION; POLYMETHYLMETHACRYLATE BONE CEMENTS; QUATERNIZED CHITOSANS; REVISION SURGERY;

CHLORINE COMPOUNDS;

ALKALINE PHOSPHATASE; ANTIBIOTIC AGENT; BONE CEMENT; CHITOSAN DERIVATIVE; GENTAMICIN BONE CEMENT; HYDROXYPROPYLTRIMETHYLAMMONIUM CHLORIDE CHITOSAN; POLY(METHYL METHACRYLATE); UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTHROPLASTY; ARTICLE; BIOFILM; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL PROLIFERATION; CEMENTED ARTHROPLASTY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROPHILICITY; INFECTION; MESENCHYMAL STEM CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; ORTHOPEDIC SURGERY; OSTEOMYELITIS; PHYSICAL PARAMETERS; POLYMERIZATION; POWDER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TEMPERATURE; X RAY DIFFRACTION;

STAPHYLOCOCCUS;

EID: 84862816064     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.03.013     Document Type: Article

References (46)

1. L. Lazzarini, J.T. Mader, and J.H. Calhoun Osteomyelitis in long bones J Bone J Surg (Am) 10 2004 2305 2318
2. C.G. Zalavras, M.J. Patzakis, and P. Holtom Local antibiotic therapy in the treatment of open fractures and osteomyelitis Clin Orthop Relat Res 427 2004 86 93
3. S. Gitelis, and G.T. Brebach The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant J Orthop Surg (Hong Kong) 10 2002 53 60
4. Z.P. Xie, X. Liu, W.T. Jia, C.Q. Zhang, W.H. Huang, and J.Q. Wang Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin J Controlled Release 139 2009 118 126
5. A. Simchi, E. Tamjid, F. Pishbin, and A.R. Boccaccini Resent progress in inorganic and composite coating with bactericidal capability for orthopaedic applications Nanomedicine:NBM 7 2011 22 39
6. H.W. Buchholz, R.A. Elson, E. Engelbrecht, H. Lodenkämper, J. Röttger, and A. Siegel Management of deep infection of total hip replacement J Bone J Surg (Br) 63-B 1981 342 353
7. A.D. Hanssen Local antibiotic delivery vehicles in the treatment of musculoskeletal infection Clin Orthop Relat Res 437 2005 91 96
8. N. Passuti, and F. Gouin Antibiotic-loaded bone cement in orthopaedic surgery Joint Bone Spine 70 2003 169 174
9. J.G. Hendriks, J.R. van Horn, H.C. van der Mei, and H.J. Busscher Backgrounds of antibiotic-loaded bone cement and prosthetic related infection Biomaterials 25 2004 545 556
10. T. Jaeblon Polymethylmethacrylate: properties and contemporary uses in orthopaedics J Am Acad Orthop Surg 18 2010 297 305
11. R.B. Bourne Prophylactic use of antibiotic bone cement: an emerging standard - in the affirmative J Arthroplasty (4 Suppl 1)19 2004 69 72
12. N. Dunne, J. Hill, P. McAfee, K. Todd, R. Kirkpatrick, and M. Tunney In vitro study of the efficacy of acrylic bone cement loaded with supplementary amounts of gentamicin effect on mechanical properties, antibiotic release, and biofilm formation Acta Orthopaedica 78 2007 774 785
13. V. Vecsei, and A. Barquet Treatment of chronic osteomyelitis by necrectomy and gentamicin-PMMA beads Clin Orthop Relat Res 159 1981 201 207
14. H. Wahlig, E. Dingeldein, R. Bergmann, and K. Reuss The release of gentamicin from polymethylmethacrylate beads: an experimental and pharmacokinetic study J Bone Joint Surg (Br) 60 1978 270 275
15. A. Montali Antibacterial coating systems Injury 37 2006 S81 S86
16. D. Campoccia, L. Montanaro, P. Speziale, and C.R. Arciola Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use Biomaterials 31 2010 6363 6377
17. L. Montanaro, D. Campoccia, and C.R. Arciol Nanostructured materials for inhibition of bacterial adhesion in orthopedic implants: a minireview Int J Artif Organs 31 2008 771 776
18. Z.L. Shi, P.H. Chua, K.G. Neoh, E.T. Kang, and W. Wang Bioactive titanium implant surfaces with bacterial inhibition and osteoblast function enhancement properties Int J Artif Organs 31 2008 777 785
19. H. Wahlig, E. Dingeldein, H.W. Buchholz, M. Buchholz, and F. Bachmann Pharmacokinetic study of gentamicin loaded cement in total hip replacements: comparative effects of varying dosage J Bone Joint Surg (Br) 66 1984 175 179
20. Y.H. Chang, V.M. Goldberg, I. Arnold, and A.I. Caplan Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells Clin Orthop Relat Res 452 2006 242 249
21. A. Ince, N. Schütze, N. Karl, J.F. Löhr, and J. Eulert Gentamicin negatively influenced osteogenic function in vitro Int Orthop 31 2007 223 228
22. S. Isefuku, C.J. Joyner, and A.H. Simpson Gentamicin may have an adverse effect on osteogenesis J Orthop Trauma 17 2003 212 216
23. C.R. Rathbone, J.D. Cross, K.V. Brown, C.K. Murray, and J.C. Wenke Effect of various concentrations of antibiotics on osteogenic cell viability and activity J Orthop Res 29 2011 1070 1074
24. N. Duewelhenke, O. Krut, and P. Eysel Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines Antimicrob Agents Chemother 51 2007 54 63
25. A. Ince, N. Schütze, C. Hendrich, F. Jakob, J. Eulert, and J.F. Löhr Effect of polyhexanide and gentamicin on human osteoblasts and endothelial cells Swiss Med Wkly 137 2007 139 145
26. R.A. Parker, P.D. Clegg, and S.E. Taylor The in vitro effects of antibiotics on cell viability and gene expression of equine bone marrow-derived mesenchymal stromal cells Equine Vet J 2011 00437x
27. I. Pountos, T. Georgouli, H. Bird, G. Kontakis, and P.V. Giannoudis The effect of antibiotics on bone healing: current evidence Expert Opin. Drug Saf 10 2011 935 945
28. Z.X. Peng, L. Wang, L. Du, S.R. Guo, X.Q. Wang, and T.T. Tang Adjustment of the antibacterial activity and biocompatibility of hydroxypropyltrimethyl ammonium chloride chitosan by varying the degree of substitution of quaternary ammonium Carbohydr Polym 81 2010 275 283
29. H.L. Tan, Z.X. Peng, Q.T. Li, X.F. Xu, S.R. Guo, and T.T. Tang The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant staphylococcus Biomaterials 33 2012 365 377
30. S.B. Kim, Y.J. Kim, T.L. Yoon, S.A. Park, I.H. Cho, and E.J. Kim The characteristics of a hydroxyapatite-chitosan-PMMA bone cement Biomaterials 25 2004 5715 5723
31. B. Pascual, B. Vázquez, M. Gurrachaga, I. Goñi, M.P. Ginebra, and F.J. Gil New aspects of the effect of size and size distribution on the setting parameters and mechanical properties of acrylic bone cements Biomaterials 17 1996 509 516
32. ISO 5833 Implants for surgery - acrylic resin cements. Switzerland: International Testing Organization; 2002.
33. T. Kokubo, and H. Takadama How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27 2006 2907 2915
34. H.L. Sun, C.T. Wu, K.R. Dai, J. Chang, and T.T. Tang Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite bioactive ceramics Biomaterials 27 2006 5651 5657
35. N. Bock, A. Riminucci, C. Dioniqi, A. Russo, A. Tampieri, and E. Landi A novel route in bone tissue engineering: magnetic biomimetic scaffolds Acta Biomaterialia 6 2010 786 796
36. L.Z. Zhao, S.G. Mei, P.K. Chu, Y.M. Zhang, and Z.F. Wu The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions Biomaterials 31 2010 5072 5082
37. C. Fukuda, K. Goto, M. Imamura, M. Neo, and T. Nakamura Bone bonding ability and handling properties of a titania-polymethylmethacrylate(PMMA) composite bioactive bone cement modified with a unique PMMA powder Acta Biomaterialia 7 2011 3595 3600
38. M. Kawashita, K. Kawamura, and Z. Li PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer Acta Biomaterialia 6 2010 3187 3192
39. K. Anselme, B. Noël, and P. Hardouin Human osteoblast adhesion on titanium alloy, stainless steel, glass and plastic substrates with same surface topography J Mater Sci Mater Med 10 1999 815 819
40. G. Altankov, F. Grinnell, and T. Groth Studies on the biocompatibility of materials: fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability J Biomed Mater Res 30 1996 385 391
41. J.M. Schakenraad, H.J. Busscher, C.R. Wildevuur, and J. Arends The influence of substratum surface free energy on growth and spreading of human fibroblasts in the presence and absence of serum proteins J Biomed Mater Res 20 1986 773 784
42. I.F. Amaral, A.L. Cordeiro, P. Sampaio, and M.A. Barbosa Attachment, spreading and short-term proliferation of human osteoblastic cells cultured on chitosan films with different degrees of acetylation J Biomater Sci Polymer Edn 18 2007 469 485
43. X. Hu, K.G. Neoh, Z. Shi, E.T. Kang, C. Poh, and W. Wang An in vitro assessment of titanium functionalized with polysaccharides conjugated with vascular endothelial growth factor for enhanced osseointegration and inhibition of bacterial adhesion Biomaterials 31 2010 1 10
44. J.L. Moreau, and H.H.K. Xu Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate - chitosan composite scaffold Biomaterials 30 2009 2675 2682
45. P.R. Klokkevold, L. Vandemark, E.B. Kenney, and G.W. Bernard Osteogenesis enhanced by chitosan (poly-n-acetyl-glucosamine) in vitro J Periodontol 67 1996 1170 1175
46. R.A. Muzzarelli, M. Mattioli-Belmonte, C. Teitz, R. Biaqini, G. Ferioli, and M.A. Brunelli Stimulatory effect on bone formation exerted by a modified chitosan Biomaterials 15 1994 1075 1081