FUS rearrangements are rare in 'pure' sclerosing epithelioid fibrosarcoma

Modern Pathology

Volumn 25, Issue 6, 2012, Pages 846-853

  Wang, Wei Lien ^a   Evans, Harry L ^a   Meis, Jeanne M ^a   Liegl Atzwanger, Bernadette ^b   Bovee, Judith V M G ^c   Goldblum, John R ^d   Billings, Steven D ^d   Rubin, Brian P ^d   López Terrada, Dolores ^e   Lazar, Alexander J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d LERNER RESEARCH INSTITUTE   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

FUS; low grade fibromyxoid sarcoma; sclerosing epithelioid sarcoma

Indexed keywords

FUSED IN SARCOMA PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; FIBROMYXOID SARCOMA; FIBROSARCOMA; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS; MORTALITY; PRIORITY JOURNAL; SARCOMA; SCLEROSING EPITHELIOID FIBROSARCOMA;

ADOLESCENT; ADULT; AGED; EPITHELIOID CELLS; EUROPE; FEMALE; FIBROSARCOMA; FIXATIVES; FORMALDEHYDE; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; NEOPLASM GRADING; PARAFFIN EMBEDDING; PROGNOSIS; RNA-BINDING PROTEIN FUS; SCLEROSIS; TIME FACTORS; TISSUE FIXATION; UNITED STATES; YOUNG ADULT;

EID: 84862814971     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.214     Document Type: Article

References (31)

1. Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. Am J Surg Pathol 1995;19:979-993.
2. Antonescu CR, Rosenblum MK, Pereira P, et al. Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am J Surg Pathol 2001;25:699-709. (Pubitemid 32496859)
3. Meis-Kindblom JM, Kindblom LG, van den Berg E, et al. Sclerosing epithelioid fibrosarcoma. In: Fletcher CDM, Unni KK, Mertens FF (eds). Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC-Press: Lyon France, 2002, pp 106-107.
4. Weiss SR, Goldblum JR, (eds). Enzinger and Weiss's Soft Tissue Tumors, 5th edn. Mosby Elsevier: St Louis, 2008, pp 310-325.
5. Lane KL, Shannon RJ, Weiss SW. Hyalinizing spindle cell tumor with giant rosettes: a distinctive tumor closely resembling low-grade fibromyxoid sarcoma. Am J Surg Pathol 1997;21:1481-1488. (Pubitemid 27528259)
6. Woodruff JM, Antonescu CR, Erlandson RA, et al. Lowgrade fibrosarcoma with palisaded granulomalike bodies (giant rosettes): report of a case that metastasized. Am J Surg Pathol 1999;23:1423-1428. (Pubitemid 29517338)
7. Folpe AL, Lane KL, Paull G, et al. Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes: a clinicopathologic study of 73 cases supporting their identity and assessing the impact of high-grade areas. Am J Surg Pathol 2000;24:1353-1360.
8. Reid R, de Silva MV, Paterson L, et al. Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes share a common t(7;16)(q34;p11) translocation. Am J Surg Pathol 2003;27:1229-1236. (Pubitemid 37040585)
9. Guillou L, Benhattar J, Gengler C, et al. Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. Am J Surg Pathol 2007;31:1387-1402. (Pubitemid 47329676)
10. Evans HL. Low-grade fibromxyoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 2011;35:1450-1462.
11. Rekhi B, Deshmukh M, Jambhekar NA. Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases. Ann Diagn Pathol 2011;15:303-311.
12. Rekhi B, Folpe AL, Deshmukh M, et al. Sclerosing epithelioid fibrosarcoma - a report of two cases with cytogenetic analysis of FUS gene rearrangement by FISH technique. Pathol Oncol Res 2011;17:145-148.
13. Elkins CT, Wakely Jr PE. Sclerosing epithelioid fibrosarcoma of the oral cavity. Head Neck Pathol 2011;5:428-423.
14. Gisselsson D, Andreasson P, Meis-Kindblom JM, et al. Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma. Cancer Genet Cytogenet 1998;107:102-106. (Pubitemid 28553112)
15. Donner LR, Clawson K, Dobin SM. Sclerosing epithelioid fibrosarcoma: a cytogenetic, immunohistochemical, and ultrastructural study of an unusual histological variant. Cancer Genet Cytogenet 2000;119:127-131. (Pubitemid 30365291)
16. Ogose A, Kawashima H, Umezu H, et al. Sclerosing epithelioid fibrosarcoma with der(10)t(10;17)(p11;q11). Cancer Genet Cytogenet 2004;152:136-140. (Pubitemid 38953016)
17. Jiao YF, Nakamura S, Sugai T, et al. Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: genetic, immunohistochemical and ultrastructural study of a case. Pathol Int 2002;52:135-140. (Pubitemid 34298100)
18. Sawyer JR, Binz RL, Gilliland JC, et al. A novel reciprocal (10;17)(p11.2;q23) in myxoid fibrosarcoma. Cancer Genet Cytogenet 2001;124:144-146. (Pubitemid 32112245)
19. Downs-Kelly E, Goldblum JR, Patel RM, et al. The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms. Am J Surg Pathol 2008;32:8-13.
20. Patel RM, Downs-Kelly E, Dandekar MN, et al. FUS (16p11) gene rearrangement as detected by fluorescence in-situ hybridization in cutaneous lowgrade fibromyxoid sarcoma: a potential diagnostic tool. Am J Dermatopathol 2011;33:140-143.
21. Weindel M, Wang WL, Demicco EG, et al. Genetic characterization and MUC4 expression in a series of histiologically characteristic low-grade fibromxyoid sarcoma [Abstract]. Mod Pathol 2011;24:23A.
22. Matsuyama A, Hisaoka M, Shimajiri S, et al. Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens. Am J Surg Pathol 2006;30:1077-1084. (Pubitemid 44299339)
23. Mertens F, Fletcher CD, Antonescu CR, et al. Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Lab Invest 2005;85:408-415. (Pubitemid 40333157)
24. Miettinen M. From morphological to molecular diagnosis of soft tissue tumors. Adv Exp Med Biol 2006;587:99-113.
25. Riggi N, Cironi L, Suva ML, et al. Sarcomas: genetics, signalling, and cellular origins. Part 1: the fellowship of TET. J Pathol 2007;213:4-20. (Pubitemid 47354561)
26. Antonescu CR, Katabi N, Zhang L, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer 2011;50:559-570.
27. Antonescu CR, Dal Cin P, Nafa K, et al. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 2007;46:1051-1060. (Pubitemid 47614539)
28. Antonescu CR, Nafa K, Segal NH, et al. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma - association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res 2006; 12:5356-5362. (Pubitemid 44497248)
29. Antonescu CR, Tschernyavsky SJ, Woodruff JM, et al. Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases. J Mol Diagn 2002;4:44-52. (Pubitemid 44698435)
30. Rossi S, Szuhai K, Ijszenga M, et al. EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res 2007;13:7322-7328.
31. Kralik JM, Kranewitter W, Boesmueller H, et al. Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia. Diagn Pathol 2011;6:19.