Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: Genetic, immunohistochemical and ultrastructural study of a case

Pathology International

Volumn 52, Issue 2, 2002, Pages 135-140

  Jiao, Yu Fei ^a   Nakamura, Shin Ichi ^a,b   Sugai, Tamotsu ^a   Uesugi, Noriyuki ^a   Habano, Wataru ^a   Ogata, Masaya ^b   Fujioka, Tomoaki ^b  

^a Central Clinical Laboratory   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Electron microscopy; Immunohistochemistry; MDM2; p53; Retroperitoneum; Sclerosing epithelioid fibrosarcoma

Indexed keywords

COLLAGEN; HYALIN; PROTEIN MDM2; PROTEIN P53; VIMENTIN;

AGED; ARTICLE; CANCER GENETICS; CANCER SURGERY; CARCINOGENESIS; CASE REPORT; CELL SHAPE; CELL ULTRASTRUCTURE; CYTOARCHITECTURE; CYTOPLASM; EPITHELIOID CELL; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; FIBROSARCOMA; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOLECULAR GENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROPERITONEAL SARCOMA; ROUGH ENDOPLASMIC RETICULUM; SCLEROSING EPITHELOID FIBROSARCOMA; TUMOR CELL;

AGED; DNA MUTATIONAL ANALYSIS; EPITHELIOID CELLS; FEMALE; FIBROSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SCLEROSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036215102     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2002.01326.x     Document Type: Article

References (20)

1. Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma
2. Sclerosing epithelioid fibrosarcoma
3. Sclerosing epithelioid fibrosarcoma: Short T2 on MR imaging
4. Sclerosing epithelioid fibrosarcoma: A study of five cases emphasizing diagnostic criteria
5. Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma
6. Sclerosing epithelioid fibrosarcoma: A cytogenetic, immunohistochemical, and ultrastructural study of an unusual histological variant
7. Sclerosing epithelioid fibrosarcomas involving the neuraxis: Report of three cases
8. A rare tumour in the pelvis presenting with lower urinary symptoms: 'Sclerosing epithelioid fibrosarcoma'
9. Sclerosing epithelioid fibrosarcoma: A study of 16 cases and confirmation of a clinicopathologically distinct tumor
10. A unique method for mutation analysis of tumor suppressor genes in colorectal carcinomas using a crypt isolation technique
11. Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma
12. Amplification of a gene encoding a p53-associated protein in human sarcomas
13. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
14. Stabilization of the MDM2 oncoprotein by mutant p53
15. The p53-mdm-2 auto-regulatory feedback loop
16. Mdm2 promotes the rapid degradation of p53
17. Mdm2: The ups and downs
18. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
19. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
20. p53-independent role of MDM2 in TGF-beta1 resistance