Translocation-positive low-grade fibromyxoid sarcoma: Clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma - A study from the French sarcoma group

American Journal of Surgical Pathology

Volumn 31, Issue 9, 2007, Pages 1387-1402

  Guillou, Louis ^a   Benhattar, Jean ^a   Gengler, Carole ^a   Gallagher, Gabrielle ^a   Ranchère Vince, Dominique ^b   Collin, Françoise ^c   Terrier, Philippe ^d   Terrier Lacombe, Marie José ^d   Leroux, Agnès ^e   Marquès, Bernard ^f   Aubain Somerhausen, Nicolas De Saint ⁱ   Keslair, Frédérique ^g   Pedeutour, Florence ^g   Coindre, Jean Michel ^h  

^a UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

^b CENTRE LÉON BÉRARD   (France)

^c Georges Francois Leclerc Cancer Center   (France)

^d INSTITUT GUSTAVE ROUSSY   (France)

^e Alexis Vautrin Cancer Center   (France)

^f INSTITUT CLAUDIUS REGAUD   (France)

^g UNIVERSITY HOSPITAL OF NICE   (France)

^h INSTITUT BERGONIÉ   (France)

ⁱ JULES BORDET INSTITUTE   (Belgium)

Author keywords

Low grade fibromyxoid sarcoma; RT PCR; Sclerosing epithelioid fibrosarcoma; t(11, 16); t(7, 16)

Indexed keywords

CD34 ANTIGEN; CD99 ANTIGEN; DESMIN; KERATIN; PARAFFIN; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN S 100; SMOOTH MUSCLE ACTIN; STEM CELL FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FIBROSARCOMA; GENE TRANSLOCATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGICAL TRAIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

ADOLESCENT; ADULT; AGED; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CHILD; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EPITHELIOID CELLS; FEMALE; FIBROMA; FIBROSARCOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; PARAFFIN EMBEDDING; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEIN FUS; SENSITIVITY AND SPECIFICITY; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 34548207864     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3180321959     Document Type: Article

References (33)

1. Antonescu CR, Rosenblum MK, Pereira P, et al. Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am J Surg Pathol. 2001;25:699-709.
2. Arnould L, Jouannelle C, Mege F, et al. Le fibrosarcome épithélioïde sclérosant: un fibrosarcome d'évolution très lente. Ann Pathol. 2000;20:154-157.
3. Bejarano PA, Padhya TA, Smith R, et al. Hyalinizing spindle cell tumor with giant rosettes-A soft tissue tumor with mesenchymal and neuroendocrine features. An immunohistochemical, ultrastructural, and cytogenetic analysis. Arch Pathol Lab Med. 2000;124:1179-1184.
4. Billings SD, Giblen G, Fanburg-Smith JC. Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathological analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol. 2005;29:204-210.
5. Bilsky MH, Schefler AM, Sandberg DI. Sclerosing epithelioid fibrosarcomas involving the neuraxis: report of three cases. Neurosurgery. 2000;47:956-960.
6. Evans HL. Low-grade fibromyxoid sarcoma: a report of two metastasizing neoplasms having a deceptively benign appearance. Am J Clin Pathol. 1987;88:615-619.
7. Evans HL. Low-grade fibromyxoid sarcoma: a report of 12 cases. Am J Surg Pathol. 1993;17:595-600.
8. Eyden BP, Manson C, Banerjee SS, et al. Sclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria. Histopathology. 1998;33:354-360.
9. Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press; 2002.
10. Folpe AL, Lane KL, Paull G, et al. Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes: a clinicopathologic study of 73 cases supporting their identity and assessing the impact of high-grade areas. Am J Surg Pathol. 2000;24:1353-1360.
11. Gisselsson D, Andreasson P, Meis-Kindblom JM, et al. Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma. Cancer Genet Cytogenet. 1998;107:102-106.
12. Goodlad JR, Mentzel T, Fletcher CD. Low grade fibromyxoid sarcoma: clinicopathological analysis of eleven new cases in support of a distinct entity. Histopathology. 1995;26:229-237.
13. Guillou L, Coindre JM, Gallagher G, et al. Detection of the synovial sarcoma translocation t(X;18)(SYT;SXX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for the pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Hum Pathol. 2001;32:105-112.
14. Hansen Hallor K, Mertens F, Jin Y, et al. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2005;44:97-102.
15. Hanson IM, Pearson JM, Eyden BP, et al. Evidence of nerve sheath differentiation and high grade morphology in sclerosing epithelioid fibrosarcoma. J Clin Pathol. 2001;54:721-723.
16. Jiao YF, Nakamura SI, Sugai T, et al. Overexpression of MDM2 in a sclerosing epithelioid fibrosarcoma: genetic, immunohistochemical and ultrastructural study of a case. Pathol Int. 2002;52:135-140.
17. Lane KL, Shannon RJ, Weiss SW. Hyalinizing spindle cell tumor with giant rosettes: a distinctive tumor closely resembling low-grade fibromyxoid sarcoma. Am J Surg Pathol. 1997;21:1481-1488.
18. Lannon CL, Sorensen PHB. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol. 2005;15:215-223.
19. Matsuyama A, Hisaoka M, Shimajiri S, et al. Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens. Am J Surg Pathol. 2006;30:1077-1084.
20. Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. Am J Surg Pathol. 1995;19:979-993.
21. Mertens F, Fletcher C, Antonescu CR, et al. Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Lab Invest. 2005;85:408-415.
22. Mezzelani A, Sozzi G, Nessling M, et al. Low grade fibromyxoid sarcoma: a further low-grade soft tissue malignancy characterized by a ring chromosome. Cancer Genet Cytogenet. 2000;122:144-148.
23. Nielsen GP, Selig MK, O'Connell JX, et al. Hyalinizing spindle cell tumor with giant rosettes. A report of three cases with ultrastructural analysis. Am J Surg Pathol. 1999;23:1227-1232.
24. O'Sullivan MJ, Sirgi KE, Dehner LP. Low grade fibromyxoid sarcoma (hyalinizing spindle cell tumor with giant rosettes) with pulmonary metastases at presentation: case report and review of the literature. Int J Surg Pathol. 2002;10:211-216.
25. Oda Y, Takahira T, Kawaguchi K, et al. Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. A comparison of clinicopathological and immunohistochemical features. Histopathology. 2004;45:29-38.
26. Ogose A, Kawashima H, Umezu H, et al. Sclerosing epithelioid fibrosarcoma with der(10)t(10;17)(p11;q11). Cancer Genet Cytogenet. 2004;152:136-140.
27. Panagopoulos I, Storlazzi CT, Fletcher CD, et al. The chimeric FUS/CREB3L2 gene is specific for low-grade fibromyxoid sarcoma. Genes Chromosomes Cancer. 2004;40:218-228.
28. Reid R, Barrett A, Hamblen DL. Sclerosing epithelioid fibrosarcoma. Histopathology. 1996;28:451-455.
29. Reid R, Chandu de Silva MV, Paterson L, et al. Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes share a common t(7;16)(q34;p11) translocation. Am J Surg Pathol. 2003;27:1229-1236.
30. Sawyer JR, Lichti Binz R, Gilliland JC, et al. A novel reciprocal (10;17)(p11.2;q23) in myxoid fibrosarcoma. Cancer Genet Cytogenet. 2001;124:144-146.
31. Storlazzi CT, Mertens F, Nascimento A, et al. Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. Hum Mol Genet. 2003;12:2349-2358.
32. Woodruff JM, Antonescu CR, Erlandson RA, et al. Low-grade fibrosarcoma with palisaded granulomalike bodies (giant rosettes). Report of a case that metastasized. Am J Surg Pathol. 1999;23:1423-1428.
33. Zamecnik M, Michal M. Low-grade fibromyxoid sarcoma: a report of eight cases with histologic, immunohistochemical, and ultrastructural study. Ann Diagn Pathol. 2000;4:207-217.