Effects of strontium on proliferation and differentiation of rat bone marrow mesenchymal stem cells

Biochemical and Biophysical Research Communications

Volumn 418, Issue 4, 2012, Pages 725-730

  Li, Yunfeng ^a   Li, Jihua ^a   Zhu, Songsong ^a   Luo, En ^a   Feng, Ge ^a   Chen, Qianming ^a   Hu, Jing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Adipocyte; BMMSCs; Differentiation; Osteoblast; Osteoporosis; Strontium

Indexed keywords

ADIPOCYTE LIPID BINDING PROTEIN 2; ALKALINE PHOSPHATASE; BINDING PROTEIN; BONE SIALOPROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPOPROTEIN LIPASE; MESSENGER RNA; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; STRONTIUM RANELATE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BONE MARROW MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; HEMATOPOIETIC STEM CELL; MALE; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FLOW CYTOMETRY; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); MESENCHYMAL STEM CELLS; ORGANOMETALLIC COMPOUNDS; PPAR GAMMA; RATS; THIOPHENES;

RATTUS;

EID: 84862813469     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.088     Document Type: Article

References (31)

1. Diagnosis, and Therapy, Osteoporosis Prevention, Diagnosis, and Therapy. JAMA 2001, 285:785-795. NIH Consensus Development Panel on Osteoporosis Prevention.
2. Liu Z., Piao J., Pang L., Qing X., Nan S., Pan Z., Guo Y., Wang X., Li F., Liu J., Cheng X. The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J. Bone Miner. Metab. 2002, 20:181-189.
3. Bonnelye E., Chabadel A., Saltel F., Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 2008, 42:129-138.
4. Bain S.D., Jerome C., Shen V., Dupin-Roger I., Ammann P. Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants. Osteoporos Int. 2009, 20:1417-1428.
5. Hwang J.S., Chen J.F., Yang T.S., Wu D.J., Tsai K.S., Ho C., Wu C.H., Su S.L., Wang C.J., Tu S.T. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis. Calcif. Tissue Int. 2008, 83:308-314.
6. Brennan T.C., Rybchyn M.S., Green W., Atwa S., Conigrave A.D., Mason R.S. Osteoblasts play key roles in the mechanisms of action of strontium ranelate. Br. J. Pharmacol. 2009, 157:1291-1300.
7. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
8. Nuttall M.E., Gimble J.M. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr. Opin. Pharmacol. 2004, 4:290-294.
9. Gimble J.M., Robinson C.E., Wu X., Kelly K.A. The function of adipocytes in the bone marrow stroma: an update. Bone 1996, 19:421-428.
10. Nuttall M.E., Patton A.J., Olivera D.L., Nadeau D.P., Gowen M. Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders. J. Bone Miner. Res. 1998, 13:371-382.
11. Meunier P., Aaron J., Edouard C., Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin. Orthop. Relat. Res. 1971, 80:147-154.
12. Rodríguez J.P., Garat S., Gajardo H., Pino A.M., Seitz G. Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics. J. Cell Biochem. 1999, 75:414-423.
13. Rodríguez J.P., Montecinos L., Ríos S., Reyes P., Martínez J. Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J. Cell Biochem. 2000, 79:557-565.
14. Astudillo P., Ríos S., Pastenes L., Pino A.M., Rodríguez J.P. Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action. J. Cell Biochem. 2008, 103:1054-1065.
15. Sugiura F., Kitoh H., Ishiguro N. Osteogenic potential of rat mesenchymal stem cells after several passages. Biochem. Biophys. Res. Commun. 2004, 316:233-239.
16. Meunier P.J., Roux C., Seeman E., Ortolani S., Badurski J.E., Spector T.D., Cannata J., Balogh A., Lemmel E.M., Pors-Nielsen S., Rizzoli R., Genant H.K., Genant H.K. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N. Engl. J. Med. 2004, 350:459-468.
17. Atkins G.J., Welldon K.J., Halbout P., Findlay D.M. Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response. Osteoporos Int. 2009, 20:653-664.
18. Elabd C., Chiellini C., Massoudi A., Cochet O., Zaragosi L.E., Trojani C., Michiels J.F., Weiss P., Carle G., Rochet N., Dechesne C.A., Dechesne C.A. Human adipose tissue-derived multipotent stem cells differentiate in vitro and in vivo into osteocyte-like cells. Biochem. Biophys. Res. Commun. 2007, 361:342-348.
19. Leskelä H.V., Olkku A., Lehtonen S., Mahonen A., Koivunen J., Turpeinen M., Uusitalo J., Pelkonen O., Kangas L., Selander K., Lehenkari P. Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts. Bone 2006, 39:1026-1034.
20. Sen A., Lea-Currie Y.R., Sujkowska D., Franklin D.M., Wilkison W.O., Halvorsen Y.D., Gimble J.M. Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J. Cell Biochem. 2001, 81:312-319.
21. Fromigué O., Marie P.J., Lomri A. Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. J. Cell Biochem. 1998, 68:411-426.
22. Marie P.J., Hott M., Modrowski D., De Pollak C., Guillemain J., Deloffre P., Tsouderos Y. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J. Bone Miner. Res. 1993, 8:607-615.
23. Hott M., Deloffre P., Tsouderos Y., Marie P.J. S12911-2 reduces bone loss induced by short-term immobilization in rats. Bone 2003, 33:115-123.
24. Arlot M.E., Jiang Y., Genant H.K., Zhao J., Burt-Pichat B., Roux J.P., Delmas P.D., Meunier P.J. Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J. Bone Miner. Res. 2008, 23:215-222.
25. Jiang Y., Jahagirdar B.N., Reinhardt R.L., Schwartz R.E., Keene C.D., Ortiz-Gonzalez X.R., Reyes M., Lenvik T., Lund T., Blackstad M., Du J., Aldrich S. L.i.s.b.e.r.g. A, Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002, 418:41-49.
26. Beresford J.N., Bennett J.H., Devlin C., Leboy P.S., Owen M.E. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 1992, 102(Pt 2):341-351.
27. Canalis E., Hott M., Deloffre P., Tsouderos Y., Marie P.J. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 1996, 18:517-523.
28. Sila-Asna M., Bunyaratvej A., Maeda S., Kitaguchi H., Bunyaratavej N. Osteoblast differentiation and bone formation gene expression in strontium-inducing bone marrow mesenchymal stem cell. Kobe J Med Sci. 2007, 53:25-35.
29. Zhu L.L., Zaidi S., Peng Y., Zhou H., Moonga B.S., Blesius A., Dupin-Roger I., Zaidi M., Sun L. Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Biochem. Biophys. Res. Commun. 2007, 355:307-311.
30. Ducy P., Zhang R., Geoffroy V., Ridall A.L., Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997, 89:747-754.
31. Peng S., Liu X.S., Wang T., Li Z., Zhou G., Luk K.D., Guo X.E., Lu W.W. In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells. J. Orthop. Res. 2010, 28:1208-1214.