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Volumn 20, Issue 3, 2012, Pages 1240-1250
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Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis
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Author keywords
Docking; Human African trypanosomiasis; Leucyl tRNA synthetase; Pharmacophore; Trypanosoma brucei; Virtual screening
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Indexed keywords
1 (3 AMINOPROPYL) 5 (4 ETHYLPHENYL) 3 HYDROXY 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
1 (4 AMINOMETHYLPHENYL) 5 (4 ETHYLPHENYL) 3 HYDROXY 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
1 (BENZO[1,3]DIOXOL 5 YL METHYL) 5 (4 ETHYLPHENYL) 3 HYDROXY 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 5 (4 TRIFLUOROMETHYLPHENYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 5 NAPHTHALEN 2 YL 1,5 DIHYDRO 2H PYRROL 2 ONE;
3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 5 PENTYL 1,5 DIHYDRO 2H PYRROL 2 ONE;
3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 5 (4 ISOBUTYLPHENYL) 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 5 (4 ISOPROPYLPHENYL) 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
4 (2,4 DIFLUOROPHENYL) 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 5 (4 ISOBUTYLPHENYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
4 (4 CHLOROBENZOYL) 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 5 (4 ISOBUTYLPHENYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
4 [2 (4 ETHYLPHENYL) 4 HYDROXY 3 (4 METHOXYBENZOYL) 5 OXO 2,5 DIHYDRO 1H PYRROL 1 YL]METHYL BENZOIC ACID;
4 N BUTYLBENZALDEHYDE;
5 (2 BROMO 4 FLUOROPHENYL) 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
5 (4 BUTYLPHENYL) 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
5 (4 ETHYLPHENYL) 3 HYDROXY 1 (3 IMIDAZOL 1 YL PROPYL) 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
5 (4 ETHYLPHENYL) 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (NAPHTHALENE 1 CARBONYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
5 (4 TERT BUTYLPHENYL) 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
5 BIPHENYL 4 YL 3 HYDROXY 1 [2 (INDOL 3 YL)ETHYL] 4 (4 METHOXYBENZOYL) 1,5 DIHYDRO 2H PYRROL 2 ONE;
ENZYME INHIBITOR;
ETHYL 2 HYDOXY 4 (4 METHOXYPHENYL) 4 OXO 2 BUTENOIC ACID;
ETHYL 2 HYDROXY 4 (NAPHTHALEN 1 YL) 4 OXO 2 BUTENOIC ACID;
ETHYL 4 (2, 4 DIFLUOROPHENYL) 2 HYDROXY 4 OXO 2 BUTENOIC ACID;
ETHYL 4 (4 CHLOROPHENYL) 2 HYDROXY 4 OXO 2 BUTENOIC ACID;
LEUCINE TRANSFER RNA LIGASE;
N (3 AMINOPROPYL) 3 METHYLBUTYRAMIDE;
N 3 [2 (4 ETHYLPHENYL) 4 HYDROXY 3 (4 METHOXYBENZOYL) 5 OXO 2,5 DIHYDRO 1H PYRROL 1 YL]PROPYL 3 METHYLBUTYRAMIDE;
TERT BUTYL 3 [2 (4 ETHYLPHENYL) 4 HYDROXY 3 (4 METHOXYBENZOYL) 5 OXO 2,5 DIHYDRO 1H PYRROL 1 YL]PROPYLCARBAMIC ACID;
TERT BUTYL 4 [2 (4 ETHYLPHENYL) 4 HYDROXY 3 (4 METHOXYBENZOYL) 5 OXO 2,5 DIHYDRO 1H PYRROL 1 YL]BENZYL CARBAMIC ACID;
UNCLASSIFIED DRUG;
ARTICLE;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
DRUG IDENTIFICATION;
DRUG MECHANISM;
DRUG SCREENING;
DRUG SYNTHESIS;
DRUG TARGETING;
IC 50;
MOLECULAR DOCKING;
MOLECULAR RECOGNITION;
PHARMACOPHORE;
PROTEIN INTERACTION;
SEQUENCE ALIGNMENT;
STRUCTURE ACTIVITY RELATION;
THREE DIMENSIONAL IMAGING;
TRYPANOSOMA BRUCEI;
AMINO ACID SEQUENCE;
ANTIPROTOZOAL AGENTS;
CATALYTIC DOMAIN;
DRUG DESIGN;
HUMANS;
LEUCINE-TRNA LIGASE;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
SEQUENCE ALIGNMENT;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRYPANOSOMA BRUCEI BRUCEI;
TRYPANOSOMIASIS, AFRICAN;
PROTOZOA;
TRYPANOSOMA BRUCEI;
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EID: 84862810944
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2011.12.035 Document Type: Article |
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Times cited : (43)
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References (39)
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