Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 13, 2003, Pages 2687-2694

  Crasto, Curtis F ^a   Forrest, Andrew K ^b   Karoli, Tomislav ^a   March, Darren R ^a   Mensah, Lucy ^b   O'Hanlon, Peter J ^b   Nairn, Michael R ^a   Oldham, Mark D ^a   Yue, Weimin ^a   Banwell, Martin G ^a   Easton, Christopher J ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 [3 [(2 AMINO 3 METHYL 1 OXOPENTYL)AMINO]PROPANOYL] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [4 [(2 AMINO 3 METHYL 1 OXOPENTYL)AMINO]BUTANOYL] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[(2 AMINO 3 METHYL 1 OXOPENTYL)AMINO]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[(2 AMINO 3 METHYLPENTANOYL)AMINOSULFONYL]ACETAMIDO] 4 CARBAMOYL 2,4A,5,6,7,7A HEXAHYDRO 6 HYDROXY 2 METHYL 1H 2 PYRINDINE 7 CARBOXYLIC ACID; 7 [[[(2 AMINO 1 OXO 5 THIAHEXYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(2 AMINO 1 OXOHEXYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(2 AMINO 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(2 AMINO 1 OXOPROPYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(2 AMINO 3 METHYL 1 OXOBUTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(2 AMINO 3 METHYL 1 OXOBUTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXYLIC ACID METHYL ESTER; 7 [[[(2 AMINO 3 METHYL 1 OXOBUTYL)AMINO]SULFONYL]ACETYLOXY] 4,4A,5,6,7,7A HEXAHYDRO 1 METHYL 1H CYCLOPENTA[B]PYRIDINE 3 CARBOXYLIC ACID METHYL ESTER; 7 [[[(2 AMINO 3 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(2 AMINO 3 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXYLIC ACID METHYL ESTER; 7 [[[(2 AMINO 3 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 4,4A,5,6,7,7A HEXAHYDRO 1 METHYL 1H CYCLOPENTA[B]PYRIDINE 3 CARBOXYLIC ACID METHYL ESTER; 7 [[[(2 AMINO 4 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXYLIC ACID METHYL ESTER; 7 [[[(2 AMINO 4 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 4,4A,5,6,7,7A HEXAHYDRO 1 METHYL 1H CYCLOPENTA[B]PYRIDINE 3 CARBOXYLIC ACID METHYL ESTER; 7 [[[(2,6 DIAMINO 1 OXOHEXYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(3 METHYL 1 OXOBUTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(3 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(4 METHYL 1 OXOPENTYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; 7 [[[(PYRROLIDIN 2 OYL)AMINO]SULFONYL]ACETYLOXY] 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H CYCLOPENTA[C]PYRIDINE 4 CARBOXAMIDE; ALANINE TRANSFER RNA LIGASE; ISOLEUCINE TRANSFER RNA LIGASE; LEUCINE TRANSFER RNA LIGASE; METHIONINE DERIVATIVE; METHIONINE TRANSFER RNA LIGASE; PROLINE TRANSFER RNA; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VALINE TRANSFER RNA LIGASE;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; EVALUATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 12444295104     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00237-2     Document Type: Article

References (7)

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