-
2
-
-
0035398526
-
A genomic perspective on human proteases as drug targets
-
Southan C: A genomic perspective on human proteases as drug targets. Drug Discov Today 2001;6(13):681-688.
-
(2001)
Drug Discov Today
, vol.6
, Issue.13
, pp. 681-688
-
-
Southan, C.1
-
3
-
-
45849098735
-
The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis
-
Cruz-Munoz W, Khokha R: The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis. Crit Rev Clin Lab Sci 2008;45(3):291-338.
-
(2008)
Crit Rev Clin Lab Sci
, vol.45
, Issue.3
, pp. 291-338
-
-
Cruz-Munoz, W.1
Khokha, R.2
-
4
-
-
0031736007
-
Protease inhibitors as antiviral agents
-
Patick AK, Potts KE: Protease inhibitors as antiviral agents. Clin Microbiol Rev 1998;11(4):614-627.
-
(1998)
Clin Microbiol Rev
, vol.11
, Issue.4
, pp. 614-627
-
-
Patick, A.K.1
Potts, K.E.2
-
5
-
-
26044454078
-
Medical aspects of toxin weapons
-
Bigalke H, Rummel A: Medical aspects of toxin weapons. Toxicology 2005;214(3):210-220.
-
(2005)
Toxicology
, vol.214
, Issue.3
, pp. 210-220
-
-
Bigalke, H.1
Rummel, A.2
-
6
-
-
0032748657
-
Clostridial toxins as therapeutic agents: Benefits of nature's most toxic proteins
-
Johnson EA. Clostridial toxins as therapeutic agents: Benefits of nature's most toxic proteins. Annu Rev Microbiol 1999;53:551-575.
-
(1999)
Annu Rev Microbiol
, vol.53
, pp. 551-575
-
-
Johnson, E.A.1
-
7
-
-
23144438784
-
New insights into clostridial neurotoxin-SNARE interactions
-
Breidenbach MA, Brunger AT: New insights into clostridial neurotoxin-SNARE interactions. Trends Mol Med 2005;11(8):377-381.
-
(2005)
Trends Mol Med
, vol.11
, Issue.8
, pp. 377-381
-
-
Breidenbach, M.A.1
Brunger, A.T.2
-
8
-
-
0035961566
-
Botulinum toxin as a biological weapon: Medical and public health management
-
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, et al.: Botulinum toxin as a biological weapon: Medical and public health management. JAMA 2001;285(16):2081.
-
(2001)
JAMA
, vol.285
, Issue.16
, pp. 2081
-
-
Arnon, S.S.1
Schechter, R.2
Inglesby, T.V.3
Henderson, D.A.4
Bartlett, J.G.5
Ascher, M.S.6
-
9
-
-
0028090321
-
Snare motif and neurotoxins
-
Rossetto O, Schiavo G, Montecucco C, Poulain B, Deloye F, Lozzi L, et al.: Snare motif and neurotoxins. Nature 1994;372(6505):415-416.
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 415-416
-
-
Rossetto, O.1
Schiavo, G.2
Montecucco, C.3
Poulain, B.4
Deloye, F.5
Lozzi, L.6
-
10
-
-
0030732413
-
Botulinum neurotoxin types A and e require the SNARE motif in SNAP-25 for proteolysis
-
Washbourne P, Pellizzari R, Baldini G, Wilson MC, Montecucco C: Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis. FEBS Lett 1997;418(1-2):1-5.
-
(1997)
FEBS Lett
, vol.418
, Issue.1-2
, pp. 1-5
-
-
Washbourne, P.1
Pellizzari, R.2
Baldini, G.3
Wilson, M.C.4
Montecucco, C.5
-
11
-
-
0032953048
-
Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: Domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage
-
Vaidyanathan VV, Yoshino K, Jahnz M, Dörries C, Bade S, Nauenburg S, et al.: Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: Domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage. J Neurochem 1999;72(1):327-337.
-
(1999)
J Neurochem
, vol.72
, Issue.1
, pp. 327-337
-
-
Vaidyanathan, V.V.1
Yoshino, K.2
Jahnz, M.3
Dörries, C.4
Bade, S.5
Nauenburg, S.6
-
12
-
-
11144341950
-
Substrate recognition strategy for botulinum neurotoxin serotype A
-
Breidenbach MA, Brunger AT: Substrate recognition strategy for botulinum neurotoxin serotype A. Nature 2004;432(7019):925-929.
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 925-929
-
-
Breidenbach, M.A.1
Brunger, A.T.2
-
13
-
-
33847323110
-
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists
-
Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, et al.: An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci USA 2007;104(8):2602- 2607.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.8
, pp. 2602-2607
-
-
Eubanks, L.M.1
Hixon, M.S.2
Jin, W.3
Hong, S.4
Clancy, C.M.5
Tepp, W.H.6
-
14
-
-
33746184737
-
Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors
-
Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, et al.: Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors. J Comb Chem 2006;8(4):513-521.
-
(2006)
J Comb Chem
, vol.8
, Issue.4
, pp. 513-521
-
-
Boldt, G.E.1
Kennedy, J.P.2
Hixon, M.S.3
McAllister, L.A.4
Barbieri, J.T.5
Tzipori, S.6
-
15
-
-
38949154627
-
Use of a recombinant fluorescent substrate with cleavage sites for all botulinum neurotoxins in high-throughput screening of natural product extracts for inhibitors of serotypes A, B, and e
-
Hines HB, Kim AD, Stafford RG, Badie SS, Brueggeman EE, Newman DJ, et al.: Use of a recombinant fluorescent substrate with cleavage sites for all botulinum neurotoxins in high-throughput screening of natural product extracts for inhibitors of serotypes A, B, and E. Appl Environ Microbiol 2008;74(3):653-659.
-
(2008)
Appl Environ Microbiol
, vol.74
, Issue.3
, pp. 653-659
-
-
Hines, H.B.1
Kim, A.D.2
Stafford, R.G.3
Badie, S.S.4
Brueggeman, E.E.5
Newman, D.J.6
-
16
-
-
0033618337
-
Matrix metalloproteinases
-
Nagase H, Woessner JF, Jr.: Matrix metalloproteinases. J Biol Chem 1999;274(31):21491-21494.
-
(1999)
J Biol Chem
, vol.274
, Issue.31
, pp. 21491-21494
-
-
Nagase, H.1
Woessner Jr., J.F.2
-
17
-
-
0027140429
-
Bacterial extracellular zinc-containing metalloproteases
-
Hase CC, Finkelstein RA: Bacterial extracellular zinc-containing metalloproteases. Microbiol Rev 1993;57(4):823-837.
-
(1993)
Microbiol Rev
, vol.57
, Issue.4
, pp. 823-837
-
-
Hase, C.C.1
Finkelstein, R.A.2
-
18
-
-
33745792627
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa
-
Saunders MJ, Kim H, Woods TA, Nolan JP, Sklar LA, Edwards BS, et al.: Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry A 2006;69(5):342-352.
-
(2006)
Cytometry A
, vol.69
, Issue.5
, pp. 342-352
-
-
Saunders, M.J.1
Kim, H.2
Woods, T.A.3
Nolan, J.P.4
Sklar, L.A.5
Edwards, B.S.6
-
19
-
-
0036088710
-
Flow cytometric analysis of ligand-receptor interactions and molecular assemblies
-
Sklar LA, Edwards BS, Graves SW, Nolan JP, Prossnitz ER.: Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annu Rev Biophys Biomol Struct 2002;31:97-119.
-
(2002)
Annu Rev Biophys Biomol Struct
, vol.31
, pp. 97-119
-
-
Sklar, L.A.1
Edwards, B.S.2
Graves, S.W.3
Nolan, J.P.4
Prossnitz, E.R.5
-
20
-
-
0035028041
-
HTPS flow cytometry: A novel platform for automated high throughput drug discovery and characterization
-
Edwards BS, Kuckuck FW, Prossnitz ER, Ransom JT, Sklar LA: HTPS flow cytometry: A novel platform for automated high throughput drug discovery and characterization. J Biomol Screen 2001;6(2):83-90.
-
(2001)
J Biomol Screen
, vol.6
, Issue.2
, pp. 83-90
-
-
Edwards, B.S.1
Kuckuck, F.W.2
Prossnitz, E.R.3
Ransom, J.T.4
Sklar, L.A.5
-
22
-
-
0028269133
-
Interaction of ebselen with glutathione-S-transferase and papain in-vitro
-
Nikawa T, Schuch G, Wagner G, Sies H: Interaction of ebselen with glutathione-S-transferase and papain in-vitro. Biochem Pharmacol 1994;47(6):1007-1012.
-
(1994)
Biochem Pharmacol
, vol.47
, Issue.6
, pp. 1007-1012
-
-
Nikawa, T.1
Schuch, G.2
Wagner, G.3
Sies, H.4
-
23
-
-
34547506296
-
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists
-
Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, et al.: An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci USA 2007;104(15):6490
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.15
, pp. 6490
-
-
Eubanks, L.M.1
Hixon, M.S.2
Jin, W.3
Hong, S.4
Clancy, C.M.5
Tepp, W.H.6
-
24
-
-
35349000590
-
Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats
-
Bubolz AH, Wu QP, Larsen BT, Gutterman DD, Liu YP: Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats. Am J Physiol Heart Circ Physiol 2007;293(4):H2231-H2237.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
, Issue.4
-
-
Bubolz, A.H.1
Wu, Q.P.2
Larsen, B.T.3
Gutterman, D.D.4
Liu, Y.P.5
-
25
-
-
0029114721
-
Molecular actions of ebselen-an antiinflammatory antioxidant
-
Schewe T: Molecular actions of ebselen-an antiinflammatory antioxidant. Gen Pharmacol 1995;26(6):1153-1169.
-
(1995)
Gen Pharmacol
, vol.26
, Issue.6
, pp. 1153-1169
-
-
Schewe, T.1
-
26
-
-
0030734080
-
Neuroprotective efficacy of ebselen, an anti-oxidant with antiinflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
-
Takasago T, Peters EE, Graham DI, Masayasu H, Macrae IM: Neuroprotective efficacy of ebselen, an anti-oxidant with antiinflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. Br J Pharmacol 1997;122(6):1251-1256.
-
(1997)
Br J Pharmacol
, vol.122
, Issue.6
, pp. 1251-1256
-
-
Takasago, T.1
Peters, E.E.2
Graham, D.I.3
Masayasu, H.4
MacRae, I.M.5
-
27
-
-
67650932715
-
Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury
-
Tunc T, Uysal B, Atabek C, Kesik V, Caliskan B, Oztas E, et al.: Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. J Surg Res 2009;155(2):210-216.
-
(2009)
J Surg Res
, vol.155
, Issue.2
, pp. 210-216
-
-
Tunc, T.1
Uysal, B.2
Atabek, C.3
Kesik, V.4
Caliskan, B.5
Oztas, E.6
-
28
-
-
70349772774
-
Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: Role of the plasma membrane H+-ATPase
-
Billack B, Santoro M, Lau-Cam C: Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: Role of the plasma membrane H+-ATPase. Microb Drug Resist 2009;15(2):77-83.
-
(2009)
Microb Drug Resist
, vol.15
, Issue.2
, pp. 77-83
-
-
Billack, B.1
Santoro, M.2
Lau-Cam, C.3
-
29
-
-
54349124541
-
New organoselenium compounds active against pathogenic bacteria, fungi and viruses
-
Pietka-Ottlik M, Wojtowicz-Mlociiowska H, Kolodziejczyk K, Piasecki E, Mlochowski J: New organoselenium compounds active against pathogenic bacteria, fungi and viruses. Chem Pharm Bull 2008;56(10):1423-1427.
-
(2008)
Chem Pharm Bull
, vol.56
, Issue.10
, pp. 1423-1427
-
-
Pietka-Ottlik, M.1
Wojtowicz-Mlociiowska, H.2
Kolodziejczyk, K.3
Piasecki, E.4
Mlochowski, J.5
-
30
-
-
33749000604
-
Ebselen, a seleno-organic antioxidant, as an electrophile
-
Sakurai T, Kanayama M, Shibata T, Itoh K, Kobayashi A, Yamamoto M, et al.: Ebselen, a seleno-organic antioxidant, as an electrophile. Chem Res Toxicol 2006;19(11):1557.
-
(2006)
Chem Res Toxicol
, vol.19
, Issue.11
, pp. 1557
-
-
Sakurai, T.1
Kanayama, M.2
Shibata, T.3
Itoh, K.4
Kobayashi, A.5
Yamamoto, M.6
-
31
-
-
54249097347
-
The strange case of the botulinum neurotoxin: Using chemistry and biology to modulate the most deadly poison
-
Willis B, Eubanks LM, Dickerson TJ, Janda KD: The strange case of the botulinum neurotoxin: Using chemistry and biology to modulate the most deadly poison. Angew Chem Int Ed Engl 2008;47(44):8360-8379.
-
(2008)
Angew Chem Int Ed Engl
, vol.47
, Issue.44
, pp. 8360-8379
-
-
Willis, B.1
Eubanks, L.M.2
Dickerson, T.J.3
Janda, K.D.4
-
32
-
-
37549021097
-
Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin A intoxication
-
Eubanks LM, Dickerson TJ: Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin A intoxication. Future Microbiol 2007;2(6):677-687.
-
(2007)
Future Microbiol
, vol.2
, Issue.6
, pp. 677-687
-
-
Eubanks, L.M.1
Dickerson, T.J.2
-
33
-
-
0034022112
-
Effect of an antioxidant, ebselen, on development of chronic cerebral vasospasm after subarachnoid hemorrhage in primates
-
Handa Y, Kaneko M, Takeuchi H, Tsuchida A, Kobayashi H, Kubota T: Effect of an antioxidant, ebselen, on development of chronic cerebral vasospasm after subarachnoid hemorrhage in primates. Surg Neurol 2000;53(4):323-329.
-
(2000)
Surg Neurol
, vol.53
, Issue.4
, pp. 323-329
-
-
Handa, Y.1
Kaneko, M.2
Takeuchi, H.3
Tsuchida, A.4
Kobayashi, H.5
Kubota, T.6
|