Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats

Pulmonary Pharmacology and Therapeutics

Volumn 25, Issue 1, 2012, Pages 99-103

  Tao, Wei ^a   Miao, Qian Bing ^a   Zhu, Ya Bing ^b   Shu, Yu Sheng ^a  

^a NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

^b HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

Acute lung injury; Inhalation; Neutrophil elastase; Sivelestat

Indexed keywords

LEUKOCYTE ELASTASE; OLEIC ACID; SIVELESTAT; SODIUM CHLORIDE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; LUNG PARENCHYMA; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RAT; SURVIVAL;

ACUTE LUNG INJURY; ADMINISTRATION, INHALATION; ALBUMINS; ANIMALS; BLOOD GAS ANALYSIS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; EXTRAVASCULAR LUNG WATER; FEMALE; GLYCINE; INJECTIONS, INTRAVENOUS; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; OLEIC ACID; OVALBUMIN; PEROXIDASE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE; SULFONAMIDES; SURVIVAL ANALYSIS;

EID: 84862806818     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2011.12.006     Document Type: Article

References (29)

1. Kinoshita M., Ono S., Mochizuki H. Neutrophils mediate acute lung injury in rabbits: role of neutrophil elastase. Eur Surg Res 2000, 32:337-346.
2. Bernard G.R., Artigas A., Brigham K.L., Carlet J., Falke K., Hudson L., et al. The American-European Consensus Conference on ARDS. Defi{ligature}nitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824.
3. Hagio T., Matsumoto S., Nakao S., Matsuoka S., Kawabata K. Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits. Pulm Pharmacol Ther 2005, 18:285-290.
4. Hagioa T., Kishikawaa T., Kawabataa K., Tasaka S., Hashimoto S., Hasegawa N., et al. Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters. Pulm Pharmacol Ther 2008, 21:884-891.
5. Kawabata K., Ishizaka A., Amaya F. Neutrophil elastase activity in acute lung injury and respiratory distress syndrome. Respirology 2008, 13:581-584.
6. Aikawa N., Ishizaka A., Hirasawa H., Shimazaki S., Yamamoto Y., Sugimoto H., et al. Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome a phase IV study. Pulm Pharmacol Ther 2011, 24:549-554.
7. Kawabata K., Suzuki M., Sugitani M., Imaki K., Toda M., Miyamoto T. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun 1991, 177:814-820.
8. Kropp J., Wencker M., Hotze A., Banik N., Hübner G.E., Wunderlich G. Inhalation of [123I] alpha1-protease inhibitor: toward a new therapeutic concept of alpha1-protease inhibitor deficiency?. JNucl Med 2001, 42:744-751.
9. Bueltmann M., Kong X., Mertens M., Yin N., Yin J., Liu Z., et al. Inhaled milrinone attenuates experimental acute lung injury. Intensive Care Med 2009, 35:171-178.
10. Yen C.C., Lai Y.W., Chen H.L., Lai C.W., Lin C.Y., Chen W., et al. Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury. PLoS One 2011, 6:e26870.
11. Nemzek J.A., Call D.R., Ebong S.J., Newcomb D.E., Bolgos G.L., Remick D.G. Immunopathology of a two-hit murine model of acid aspiration lung injury. Am J Physiol Lung Cell Mol Physiol 2000, 278:L512-L520.
12. Yoshimura K., Nakagawa S., Koyama S., Kobayashi T., Homma T. Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit. JAppl Physiol 1994, 76:91-96.
13. Abraham E., Carmody A., Shenkar R., Arcaroli J. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 2000, 279:L1137-L1145.
14. Abraham E. Neutrophils and acute lung injury. Crit Care Med 2003, 31:195-199.
15. Klebanoff S.J. Myeloperoxidase: friend and foe. JLeukoc Biol 2005, 77:598-625.
16. Matsuzaki K., Hiramatsu Y., Homma S., Sato S., Shigeta O., Sakakibara Y. Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. Ann Thorac Surg 2005, 80:611-617.
17. Suzuki S., Sugawara T., Tabata T., Oishi H., Niikawa H., Kondo T. Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation. JHeart Lung Transplant 2007, 26:370-375.
18. Sun Y., Yang R., Zhong J.G., Fang F., Jiang J.J., Liu M.Y., et al. Aerosolised surfactant generated by a novel noninvasive apparatus reduced acute lung injury in rats. Crit Care 2009, 13:R31.
19. Hagiwara S., Iwasaka H., Hidaka S., Hasegawa A., Noguchi T. Neutrophil elastase inhibitor (Sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm Res 2009, 58:198-203.
20. Tao W, Shu YS, Miao QB, Zhu YB. Attenuation of hyperoxia-induced lung injury in rats by adrenomedullin. Inflammation, In press.
21. Hagiwara S., Iwasaka H., Togo K., Noguchi T. Aneutrophil elastase inhibitor, Sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1. Inflammation 2008, 31:227-234.
22. Simon R.H., DeHart P.D., Todd R.F. Neutrophil-induced injury of rat pulmonary alveolar epithelial cells. JClin Invest 1986, 78:1375-1386.
23. Carden D., Xiao F., Moak C., Willis B.H., Robinson-Jackson S., Alexander S. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol 1998, 275:H385-H392.
24. Miyazaki Y., Inoue T., Kyi M., Sawada M., Miyake S., Yoshizawa Y. Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs. Am J Respir Crit Care Med 1998, 157:89-94.
25. Ishii T., Doi K., Okamoto K., Imamura M., Dohi M., Yamamoto K. Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy. Am J Pathol 2010, 177:1665-1673.
26. Harada N., Okajima K., Isobe H. Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats. Shock 2008, 30:379-387.
27. Sakashita A., Nishimura Y., Nishiuma T., et al. Neutrophil elastase inhibitor (Sivelestat) attenuates subsequent ventilator-induced lung injury in mice. Eur J Pharmacol 2007, 571:62-71.
28. Okayama N., Kakihana Y., Setoguchi D., et al. Clinical effects of a neutrophil elastase inhibitor, Sivelestat, in patients with acute respiratory distress syndrome. JAnesth 2006, 20:6-10.
29. Endo S., Sato N., Yaegashi Y., et al. Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction. Res Commun Mol Pathol Pharmacol 2006, 119:53-65.