A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1

Inflammation

Volumn 31, Issue 4, 2008, Pages 227-234

  Hagiwara, Satoshi ^a   Iwasaka, Hideo ^a   Togo, Kazumi ^a   Noguchi, Takayuki ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Cytokine; High mobility group box 1; Inflammation; NF B; Nitric oxide; Sepsis

Indexed keywords

ENDOTOXIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LEUKOCYTE ELASTASE INHIBITOR; LIPOPOLYSACCHARIDE; NITRATE; NITRITE; SIVELESTAT; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRY WEIGHT; HISTOPATHOLOGY; LUNG PARENCHYMA; MALE; NONHUMAN; PNEUMONIA; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RANDOMIZATION; RAT; SEPSIS; SHOCK; TISSUE LEVEL; TREATMENT OUTCOME;

ANIMALS; GLYCINE; HMGB1 PROTEIN; INTERLEUKIN-6; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDES; LUNG; MALE; NF-KAPPA B; NITRATES; NITRITES; RATS; RATS, WISTAR; SERINE PROTEINASE INHIBITORS; SHOCK, SEPTIC; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 47649096971     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-008-9069-z     Document Type: Article

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