Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters

Pulmonary Pharmacology and Therapeutics

Volumn 21, Issue 6, 2008, Pages 884-891

  Hagio, Tetsuya ^a   Kishikawa, Katsuya ^a   Kawabata, Kazuhito ^a   Tasaka, Sadatomo ^b   Hashimoto, Satoru ^c   Hasegawa, Naoki ^b   Ishizaka, Akitoshi ^b  

^a ONO PHARMACEUTICAL CO   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Acute lung injury; Bacterial infection; Protease inhibitor; Sivelestat; Surfactant protein D

Indexed keywords

ELASTASE INHIBITOR; HUMAN SERUM ALBUMIN; LEUKOCYTE ELASTASE; SIVELESTAT; SODIUM CHLORIDE; SURFACTANT PROTEIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL INFECTION; CELL MEMBRANE PERMEABILITY; CONTINUOUS INFUSION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; ENZYME INHIBITION; HAMSTER; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STREPTOCOCCUS PNEUMONIAE;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; COLONY COUNT, MICROBIAL; CRICETINAE; DISEASE MODELS, ANIMAL; GLYCINE; LEUKOCYTE ELASTASE; MESOCRICETUS; PNEUMONIA, PNEUMOCOCCAL; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; STREPTOCOCCUS PNEUMONIAE; SULFONAMIDES; TIME FACTORS;

EID: 56949084283     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.10.002     Document Type: Article

References (25)

1. Havemann K., and Gramse M. Physiology and pathophysiology of neutral proteinases of human granulocytes. Adv Exp Med Biol 167 (1984) 1-20
2. Belaaouaj A., McCarthy R., Baumann M., Gao Z., Ley T.J., Abraham S.N., et al. Mice lacking neutrophil elastase reveal impaired host defense against Gram-negative bacterial sepsis. Nat Med 4 (1998) 615-618
3. Weiss S.J. Tissue destruction by neutrophils. N Engl J Med 320 (1989) 365-376
4. Morrison H.M., Welgus H.G., Stockley R.A., Burnett D., and Campbell E.J. Inhibition of human leukocyte elastase bound to elastin: relative ineffectiveness and two mechanisms of inhibitory activity. Am J Respir Cell Mol Biol 2 (1990) 263-269
5. Kawabata K., Moore A.R., and Willoughby D.A. Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage. Ann Rheum Dis 55 (1996) 248-252
6. Kawabata K., Hagio T., Matsumoto S., Nakao S., Orita S., Aze, et al. Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. Am J Respir Crit Care Med 161 (2000) 2013-2018
7. Hagio T., Nakao S., Matsuoka H., Matsumoto S., Kawabata K., and Ohno H. Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. Eur J Pharmacol 426 (2001) 131-138
8. Hagio T., Matsumoto S., Nakao S., Abiru T., Ohno H., and Kawabata K. Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. Eur J Pharmacol 488 (2004) 173-180
9. Hirche T.O., Crouch E.C., Espinola M., Brokelman T.J., Mecham R.P., DeSilva N., et al. Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. J Biol Chem 279 (2004) 27688-27698
10. Rubio F., Cooley J., Accurso F.J., and Remold-O'Donnell E. Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease. Thorax 59 (2004) 318-323
11. Wright J.R. Immunoregulatory functions of surfactant proteins. Nat Rev Immunol 5 (2005) 58-68
12. Hartl D., Latzin P., Hordijk P., Marcos V., Rudolph C., Woischnik M., et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med 13 (2007) 1423-1430
13. Kawabata K., Suzuki M., Sugitani M., Imaki K., Toda M., and Miyamoto T. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun 177 (1991) 814-820
14. Zeiher B.G., Matsuoka S., Kawabata K., and Repine J.E. Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. Crit Care Med 30 (2002) S281-S287
15. Akimoto A., Mori H., Namba T., Matsuoka S., Ohshima Y., Suzuki T., et al. The effects of sivelestat sodium hydrate (ONO-5046·Na) on neutrophil phylaxis function in vitro. Jpn Pharmacol Ther 31 (2003) 85-91
16. Neeleman C., Geelen S.P., Aerts P.C., Daha M.R., Mollnes T.E., Roord J.J., et al. Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H. Infect Immun 67 (1999) 4517-4524
17. Yoshimura K., Nakagawa S., Koyama S., Kobayashi T., and Homma T. Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit. J Appl Physiol 76 (1994) 91-96
18. Sibille Y., and Reynolds H.Y. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 141 (1990) 471-501
19. Tonai T., Shiba K., Taketani Y., Ohmoto Y., Murata K., Muraguchi M., et al. A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. J Neurochem 78 (2001) 1064-1072
20. Garcia-Suarez Mdel M., Florez N., Astudillo A., Vazquez F., Villaverde R., Fabrizio K., et al. The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model. Respir Res 8 (2007) 3
21. Moreland J.G., and Bailey G. Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent. Am J Physiol Lung Cell Mol Physiol 290 (2006) L833-L840
22. Hartshorn K.L., Crouch E., White M.R., Colamussi M.L., Kakkanatt A., Tauber B., et al. Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria. Am J Physiol 274 (1998) L958-L969
23. Marks M., Burns T., Abadi M., Seyoum B., Thornton J., Tuomanen E., et al. Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun 75 (2007) 1586-1597
24. Sedor J., Hogue L., Akers K., Boslaugh S., Schreiber J., and Ferkol T. Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs. Pediatr Res 61 (2007) 26-31
25. Benarafa C., Priebe G.P., and Remold-O'Donnell E. The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. J Exp Med 204 (2007) 1901-1909