Activation of 5-HT7 receptors increases neuronal platelet-derived growth factor β receptor expression

Neuroscience Letters

Volumn 511, Issue 2, 2012, Pages 65-69

  Vasefi, Maryam S ^a   Kruk, Jeff S ^a   Liu, Hui ^a   Heikkila, John J ^a   Beazely, Michael A ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

5 HT7; Hippocampus; PDGF; Protein expression; Schizophrenia

Indexed keywords

5 CARBAMOYLTRYPTAMINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOLIPASE C GAMMA; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SEROTONIN; SEROTONIN 7 RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; LINKAGE ANALYSIS; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION; MICE; NEURONS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, SEROTONIN; UP-REGULATION;

EID: 84862802465     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.01.016     Document Type: Article

References (33)

1. Andrae J., Gallini R., Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008, 22:1276-1312.
2. Andressen K.W., Norum J.H., Levy F.O., Krobert K.A. Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression. Mol. Pharmacol. 2006, 69:207-215.
3. Beazely M.A., Tong A., Wei W.L., Van Tol H., Sidhu B., MacDonald J.F. D2-class dopamine receptor inhibition of NMDA currents in prefrontal cortical neurons is platelet-derived growth factor receptor-dependent. J. Neurochem. 2006, 98:1657-1663.
4. Beazely M.A., Lim A., Li H., Trepanier C., Chen X., Sidhu B., Macdonald J.F. Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-d-aspartate receptors in CA1 hippocampal neurons. J. Biol. Chem. 2009, 284:8054-8063.
5. Born G.V., Juengjaroen K., Michal F. Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues. Br. J. Pharmacol. 1972, 44:117-139.
6. Crider J.Y., Williams G.W., Drace C.D., Katoli P., Senchyna M., Sharif N.A. Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2003, 44:4837-4844.
7. Eglen R.M., Jasper J.R., Chang D.J., Martin G.R. The 5-HT7 receptor: orphan found. Trends Pharmacol. Sci. 1997, 18:104-107.
8. Heldin C.H., Ostman A., Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1998, 1378:F79-F113.
9. Hirst W.D., Price G.W., Rattray M., Wilkin G.P. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. Br. J. Pharmacol. 1997, 120:509-515.
10. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 1994, 46:157-203.
11. Kotecha S.A., Oak J.N., Jackson M.F., Perez Y., Orser B.A., Van Tol H.H., MacDonald J.F. A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron 2002, 35:1111-1122.
12. Krobert K.A., Bach T., Syversveen T., Kvingedal A.M., Levy F.O. The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch. Pharmacol. 2001, 363:620-632.
13. Kvachnina E., Liu G., Dityatev A., Renner U., Dumuis A., Richter D.W., Dityateva G., Schachner M., Voyno-Yasenetskaya T.A., Ponimaskin E.G. 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology. J. Neurosci. 2005, 25:7821-7830.
14. Lei S., Lu W.Y., Xiong Z.G., Orser B.A., Valenzuela C.F., MacDonald J.F. Platelet-derived growth factor receptor-induced feed-forward inhibition of excitatory transmission between hippocampal pyramidal neurons. J. Biol. Chem. 1999, 274:30617-30623.
15. Leopoldo M., Lacivita E., Contino M., Colabufo N.A., Berardi F., Perrone R. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J. Med. Chem. 2007, 50:4214-4221.
16. Leopoldo M., Lacivita E., De Giorgio P., Fracasso C., Guzzetti S., Caccia S., Contino M., Colabufo N.A., Berardi F., Perrone R. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. J. Med. Chem. 2008, 51:5813-5822.
17. Liu Y., Li M., Warburton R.R., Hill N.S., Fanburg B.L. The 5-HT transporter transactivates the PDGFbeta receptor in pulmonary artery smooth muscle cells. FASEB J. 2007, 21:2725-2734.
18. Lovenberg T.W., Baron B.M., de Lecea L., Miller J.D., Prosser R.A., Rea M.A., Foye P.E., Racke M., Slone A.L., Siegel B.W., Danielson P.E., Sutcliffe J.G., Erlander M.G. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron 1993, 11:449-458.
19. Mahe C., Bernhard M., Bobirnac I., Keser C., Loetscher E., Feuerbach D., Dev K.K., Schoeffter P. Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines. Br. J. Pharmacol. 2004, 143:404-410.
20. Mahe C., Loetscher E., Feuerbach D., Muller W., Seiler M.P., Schoeffter P. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur. J. Pharmacol. 2004, 495:97-102.
21. May J.A., McLaughlin M.A., Sharif N.A., Hellberg M.R., Dean T.R. Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. J. Pharmacol. Exp. Ther. 2003, 306:301-309.
22. Nebigil C.G., Launay J.M., Hickel P., Tournois C., Maroteaux L. 5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:2591-2596.
23. Oak J.N., Lavine N., Van Tol H.H. Dopamine D(4) and D(2L) receptor stimulation of the mitogen-activated protein kinase pathway is dependent on trans-activation of the platelet-derived growth factor receptor. Mol. Pharmacol. 2001, 60:92-103.
24. Raymond J.R., Mukhin Y.V., Gelasco A., Turner J., Collinsworth G., Gettys T.W., Grewal J.S., Garnovskaya M.N. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol. Ther. 2001, 92:179-212.
25. Ren W., Watts S.W., Fanburg B.L. Serotonin transporter interacts with the PDGFbeta receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 2010, 300:L486-L497.
26. Romero G., Pujol M., Pauwels P.J. Reanalysis of constitutively active rat and human 5-HT7(a) receptors in HEK-293F cells demonstrates lack of silent properties for reported neutral antagonists. Naunyn Schmiedebergs Arch. Pharmacol. 2006, 374:31-39.
27. Shah B.H., Catt K.J. GPCR-mediated transactivation of RTKs in the CNS: mechanisms and consequences. Trends Neurosci. 2004, 27:48-53.
28. Smits A., Kato M., Westermark B., Nister M., Heldin C.H., Funa K. Neurotrophic activity of platelet-derived growth factor (PDGF): rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. Proc. Natl. Acad. Sci. U. S. A. 1991, 88:8159-8163.
29. Stam N.J., Roesink C., Dijcks F., Garritsen A., van Herpen A., Olijve W. Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants. FEBS Lett. 1997, 413:489-494.
30. Thomas D.R., Hagan J.J. 5-HT7 receptors. Curr. Drug Targets CNS Neurol. Disord. 2004, 3:81-90.
31. Thomas E.A., Cravatt B.F., Sutcliffe J.G. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. J. Neurochem. 1999, 72:2370-2378.
32. Valenzuela C.F., Xiong Z., MacDonald J.F., Weiner J.L., Frazier C.J., Dunwiddie T.V., Kazlauskas A., Whiting P.J., Harris R.A. Platelet-derived growth factor induces a long-term inhibition of N-methyl-d-aspartate receptor function. J. Biol. Chem. 1996, 271:16151-16159.
33. Wolfel R., Graefe K.H. Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. Naunyn Schmiedebergs Arch. Pharmacol. 1992, 345:129-136.