Harpagoside attenuates MPTP/MPP + induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor

Journal of Neurochemistry

Volumn 120, Issue 6, 2012, Pages 1072-1083

  Sun, Xiaoyu ^a   Xiong, Zhongkui ^a   Zhang, Yongfang ^a,b   Meng, Ya ^c   Xu, Gang ^a   Xia, Zhiming ^a   Li, Jiamei ^a   Zhang, Rui ^a,b   Ke, Zunji ^c   Xia, Zongqin ^a,b   Hu, Yaer ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b China swzlym onlineshcn   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Dopaminergic neurons; Glial cell line derived neurotrophic factor; Harpagoside; MPTP MPP + intoxication; Neurodegeneration; Tyrosine hydroxylase

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE TRANSPORTER; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HARPAGOSIDE; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; EMBRYO; FEMALE; LOCOMOTION; MALE; MESENCEPHALON; MOTOR DYSFUNCTION; MOUSE; NERVE CELL CULTURE; NERVE DEGENERATION; NERVE FIBER; NEUROPROTECTION; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SUBSTANTIA NIGRA PARS COMPACTA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ANTIBODIES; AXONS; CELLS, CULTURED; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINERGIC NEURONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLYCOSIDES; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; MPTP POISONING; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PREGNANCY; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; ROTAROD PERFORMANCE TEST; TYROSINE 3-MONOOXYGENASE;

SCROPHULARIA NINGPOENSIS;

EID: 84862794801     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07635.x     Document Type: Article

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