Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica

Applied Microbiology and Biotechnology

Volumn 95, Issue 1, 2012, Pages 157-168

  Lee, Mi Jin ^a   Kong, Dekun ^b   Han, Kyuboem ^c   Sherman, David H ^d   Bai, Linquan ^b   Deng, Zixin ^b   Lin, Shuangjun ^b   Kim, Eung Soo ^a  

^a Inha University   (South Korea)

^b Shanghai Jiao Tong University   (China)

^c Cha Bio and Diostech Bio Pharmaceutical Research Institute   (South Korea)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Antifungal; Less hemolytic; Nystatin; Polyene; Pseudonocardia

Indexed keywords

ANTI-FUNGAL; LESS-HEMOLYTIC; NYSTATIN; POLYENE; PSEUDONOCARDIA;

ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; FUNGI; GENES; KETONES; SOLUBILITY; SUGARS;

ORGANIC COMPOUNDS;

ANTIFUNGAL AGENT; BACTERIAL DNA; CYTOCHROME P450; GLUCOSAMINE; GLYCOSYLTRANSFERASE; MYCOSAMINYL(ALPHA1-4) N ACETYLGLUCOSAMINE; NYSTATIN; NYSTATIN D1; POLYENE ANTIBIOTIC AGENT; POLYENE CYTOCHROME P450 HYDROXYLASE; UNCLASSIFIED DRUG;

ANTIBIOTICS; BACTERIUM; BIOENGINEERING; CYTOCHROME; ENZYME ACTIVITY; MITOCHONDRIAL DNA; PROTEIN; SOLUBILITY;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; BIOENGINEERING; BIOSYNTHESIS; CANDIDA ALBICANS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPATHOGENIC EFFECT; DELETION MUTANT; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GENE CLUSTER; GENE INACTIVATION; GENOME ANALYSIS; HEMOLYSIS; MOLECULAR CLONING; NONHUMAN; OPEN READING FRAME; PSEUDONOCARDIA AUTOTROPHICA; PSEUDONOCARDIACEAE; STRUCTURE ANALYSIS;

ACTINOMYCETALES; ANTIFUNGAL AGENTS; BIOTECHNOLOGY; CANDIDA ALBICANS; FUNGAL PROTEINS; GENETIC ENGINEERING; HEMOLYSIS; MICROBIAL SENSITIVITY TESTS; MULTIGENE FAMILY; MUTATION; NYSTATIN; POLYENES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

ACTINOBACTERIA (CLASS); CANDIDA ALBICANS; PSEUDONOCARDIA; PSEUDONOCARDIA AUTOTROPHICA;

EID: 84862794121     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-3955-x     Document Type: Article

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