Molecular effects of activated BV-2 microglia by mitochondrial toxin 1-methyl-4-phenylpyridinium

NeuroToxicology

Volumn 33, Issue 2, 2012, Pages 147-155

  Jin, Meihua ^a   Kim, Byung Wook ^a   Koppula, Sushruta ^a   Kim, In Su ^a   Park, Ji Hwan ^a   Kumar, Hemant ^a   Choi, Dong Kug ^a  

^a Konkuk University   (South Korea)

Author keywords

BV 2 cells; Caspase 3; Microglia; MPP +; PARP

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BIOLOGICAL MARKER; CASPASE 3; CD11B ANTIGEN; CYTOTOXIN; IODIDE ION; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL FATE; CELL VIABILITY; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY TEST; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME DEGRADATION; GLIOSIS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MALE; MICROGLIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOUSE; NERVE CELL NECROSIS; NERVE CELL STIMULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SUBSTANTIA NIGRA PARS COMPACTA;

1-METHYL-4-PHENYLPYRIDINIUM; ANALYSIS OF VARIANCE; ANIMALS; ANNEXIN A5; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CASPASE 3; CELL COUNT; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HERBICIDES; LIPOPOLYSACCHARIDES; MACROPHAGE-1 ANTIGEN; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84862794060     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.12.019     Document Type: Article

References (39)

1. Albright A.V., Gonzalez-Scarano F. Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression. J Neuroimmunol 2004, 157:27-38.
2. Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 1990, 27:229-237.
3. Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005, 76:77-98.
4. Block M.L., Li G., Qin L., Wu X., Pei Z., Wang T., et al. Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin. FASEB J 2006, 20:251-258.
5. Blum D., Torch S., Lambeng N., Nissou M., Benabid A.L., Sadoul R., et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001, 65:135-172.
6. Bocchini V., Mazzolla R., Barluzzi R., Blasi E., Sick P., Kettenmann H. An immortalized cell line expresses properties of activated microglial cells. J Neurosci Res 1992, 31:616-621.
7. Boulet I., Ralph S., Stanley E., Lock P., Dunn A.R., Green S.P., et al. Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogene 1992, 7:703-710.
8. Chetsawang B., Chetsawang J., Govitrapong P. Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. J Pineal Res 2009, 46:36-42.
9. Chun H.S., Gibson G.E., DeGiorgio L.A., Zhang H., Kidd V.J., Son J.H. Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem 2001, 76:1010-1021.
10. Czlonkowska A., Kohutnicka M., Kurkowska-Jastrzebska I., Czlonkowski A. Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model. Neurodegeneration 1996, 5:137-143.
11. Eikelenboom P., Bate C., Van Gool W.A., Hoozemans J.J., Rozemuller J.M., Veerhuis R., et al. Neuroinflammation in Alzheimer's disease and prion disease. Glia 2002, 40:232-239.
12. Fadeel B. Programmed cell clearance. Cell Mol Life Sci 2003, 60:2575-2585.
13. Gao H.M., Hong J.S., Zhang W., Liu B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2002, 22:782-790.
14. Gao H.M., Liu B., Hong J.S. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2003, 23:6181-6187.
15. Henn A., Lund S., Hedtjarn M., Schrattenholz A., Porzgen P., Leist M. The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. ALTEX 2009, 26:83-94.
16. +) and in vivo against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a comparison to ropinirole. Exp Neurol 2003, 184:393-407.
17. Kannan K., Jain S.K. Oxidative stress and apoptosis. Pathophysiology 2000, 7:153-163.
18. Kim E.J., Won R., Sohn J.H., Chung M.A., Nam T.S., Lee H.J., et al. Anti-oxidant effect of ascorbic and dehydroascorbic acids in hippocampal slice culture. Biochem Biophys Res Commun 2008, 366:8-14.
19. Kitamura Y., Kosaka T., Kakimura J.I., Matsuoka Y., Kohno Y., Nomura Y., et al. Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells. Mol Pharmacol 1998, 54:1046-1054.
20. Kohutnicka M., Lewandowska E., Kurkowska-Jastrzebska I., Czlonkowski A., Czlonkowska A. Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunopharmacology 1998, 39:167-180.
21. Langston J.W., Irwin I. MPTP: current concepts and controversies. Clin Neuropharmacol 1986, 9:485-507.
22. Lee C.S., Park W.J., Ko H.H., Han E.S. Differential involvement of mitochondrial permeability transition in cytotoxicity of 1-methyl-4-phenylpyridinium and 6-hydroxydopamine. Mol Cell Biochem 2006, 289:193-200.
23. Lee P., Lee J., Kim S., Lee M.S., Yagita H., Kim S.Y., et al. NO as an autocrine mediator in the apoptosis of activated microglial cells: correlation between activation and apoptosis of microglial cells. Brain Res 2001, 892:380-385.
24. Liberatore G.T., Jackson-Lewis V., Vukosavic S., Mandir A.S., Vila M., McAuliffe W.G., et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 1999, 5:1403-1409.
25. Liu B., Wang K., Gao H.M., Mandavilli B., Wang J.Y., Hong J.S. Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J Neurochem 2001, 77:182-189.
26. Lund S., Christensen K.V., Hedtjarn M., Mortensen A.L., Hagberg H., Falsig J., et al. The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. J Neuroimmunol 2006, 180:71-87.
27. Miller R.L., Sun G.Y., Sun A.Y. Cytotoxicity of paraquat in microglial cells: involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. Brain Res 2007, 1167:129-139.
28. Nelson P.T., Soma L.A., Lavi E. Microglia in diseases of the central nervous system. Ann Med 2002, 34:491-500.
29. Park K.W., Lee D.Y., Joe E.H., Kim S.U., Jin B.K. Neuroprotective role of microglia expressing interleukin-4. J Neurosci Res 2005, 81:397-402.
30. Polster B.M., Fiskum G. Mitochondrial mechanisms of neural cell apoptosis. J Neurochem 2004, 90:1281-1289.
31. Ryu J.K., Nagai A., Kim J., Lee M.C., McLarnon J.G., Kim S.U. Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies. Neurobiol Dis 2003, 12:121-132.
32. Shin W.H., Lee D.Y., Park K.W., Kim S.U., Yang M.S., Joe E.H., et al. Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo. Glia 2004, 46:142-152.
33. Suk K. Regulation of neuroinflammation by herbal medicine and its implications for neurodegenerative diseases. A focus on traditional medicines and flavonoids. Neurosignals 2005, 14:23-33.
34. Suk K. Role of caspases in activation-induced cell death of neuroglia. Curr Enzyme Inhib 2005, 1:8.
35. Takano K., Nakamura Y., Yoneda Y. Microglial cell death induced by a low concentration of polyamines. Neuroscience 2003, 120:961-967.
36. Thomas D.M., Walker P.D., Benjamins J.A., Geddes T.J., Kuhn D.M. Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. J Pharmacol Exp Ther 2004, 311:1-7.
37. Wu D.C., Teismann P., Tieu K., Vila M., Jackson-Lewis V., Ischiropoulos H., et al. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A 2003, 100:6145-6150.
38. Wu Y., Shang Y., Sun S., Liu R. Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells. Eur J Pharmacol 2007, 564:47-56.
39. Zierler S., Klein B., Furtner T., Bresgen N., Lutz-Meindl U., Kerschbaum H.H. Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2. Brain Res 2006, 1121:12-21.