L-theanine partially counteracts caffeine-induced sleep disturbances in rats

Pharmacology Biochemistry and Behavior

Volumn 101, Issue 2, 2012, Pages 217-221

  Jang, Hwan Soo ^a,b   Jung, Ji Young ^a   Jang, Il Sung ^b   Jang, Kwang Ho ^b   Kim, Sang Hyun ^a   Ha, Jeoung Hee ^a   Suk, Kyoungho ^a,b   Lee, Maan Gee ^a,b  

^a Kyungpook National University School of Medicine   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Caffeine; Insomnia; L theanine; Rat; Sleep wake architecture

Indexed keywords

CAFFEINE; THEANINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; INSOMNIA; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REM SLEEP; SLOW WAVE SLEEP; WAKEFULNESS;

ANIMALS; CAFFEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMATES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SLEEP DISORDERS; SLEEP STAGES; WAKEFULNESS;

RATTUS;

EID: 84862791079     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.01.011     Document Type: Article

References (17)

1. J.J. Barone, and H.R. Roberts Caffeine consumption Food Chem Toxicol 34 1996 119 129 (Pubitemid 26057854)
2. M.H. Bonnet, and D.L. Arand Caffeine use as a model of acute and chronic insomnia Sleep 15 1992 526 536
3. J. Deckert, and C.H. Gleiter Adenosinergic psychopharmaceuticals? Trends Pharmacol Sci 10 1989 99 100
4. B.A. Edelstein, C. Keaton-Brasted, and M.M. Burg Effects of caffeine withdrawal on nocturnal enuresis, insomnia, and behavior restraints J Consult Clin Psychol 52 1984 857 862 (Pubitemid 15124758)
5. C.F. Haskell, D.O. Kennedy, A.L. Milne, K.A. Wesnes, and A.B. Scholey The effects of L-theanine, caffeine and their combination on cognition and mood Biol Psychol 77 2008 113 122
6. S. Heatherley, E. Mullings, M. Tidbury, and P. Rogers Caffeine consumption among a sample of UK adults Appetite 47 2006 266
7. T. Kakuda, A. Nozawa, T. Unno, N. Okamura, and O. Okai Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat Biosci Biotechnol Biochem 64 2000 287 293
8. I. Karacan, J.I. Thornby, M. Anch, G.H. Booth, R.L. Williams, and P.J. Salis Dose-related sleep disturbances induced by coffee and caffeine Clin Pharmacol Ther 20 1976 682 689 (Pubitemid 8020948)
9. K. Kimura, M. Ozeki, L.R. Juneja, and H. Ohira L-Theanine reduces psychological and physiological stress responses Biol Psychol 74 2007 39 45 (Pubitemid 44781395)
10. D.H. Kwon, S.H. Won, K.M. Kim, S.M. Chang, S.H. Kim, and M.G. Lee Effect of caffeine on sleep and EEG spectra in rats J Korean Soc Biol Ther Psychiatry 12 2006 252 267
11. K. Morgan, D.W. Healey, and P.J. Healey Factors influencing persistent subjective insomnia in old age: a follow-up study of good and poor sleepers aged 65 to 74 Age Ageing 18 1989 117 122 (Pubitemid 19206287)
12. L.M. Paterson, S.J. Wilson, D.J. Nutt, P.H. Hutson, and M. Ivarsson A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers Psychopharmacology (Berl) 191 2007 943 950 (Pubitemid 46399141)
13. P.J. Rogers, J.E. Smith, S.V. Heatherley, and C.W. Pleydell-Pearce Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together Psychopharmacology (Berl) 195 2008 569 577 (Pubitemid 350160491)
14. B. Schwierin, A.A. Borbely, and I. Tobler Effects of N6- cyclopentyladenosine and caffeine on sleep regulation in the rat Eur J Pharmacol 300 1996 163 171 (Pubitemid 26144794)
15. K. Shinomiya, J. Omichi, R. Ohnishi, H. Ito, T. Yoshida, and C. Kamei Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats Eur J Pharmacol 504 2004 185 189 (Pubitemid 39488214)
16. J.K. Walsh, J.L. Sugerman, and G.W. Chambers Evaluation of insomnia Am Fam Physician 33 1986 185 194 (Pubitemid 16043085)
17. J.P. Wisor, D.M. Edgar, J. Yesavage, H.S. Ryan, C.M. McCormick, and N. Lapustea Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission Neuroscience 131 2005 375 385 (Pubitemid 40222446)