A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers

Psychopharmacology

Volumn 191, Issue 4, 2007, Pages 943-950

  Paterson, Louise M ^a   Wilson, Sue J ^a   Nutt, David J ^a   Hutson, Peter H ^b   Ivarsson, Magnus ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Caffeine; Healthy volunteer; Insomnia; Polysomnography; Rat; Sleep; Telemetry; Trazodone; Zolpidem

Indexed keywords

CAFFEINE; DRUG VEHICLE; PLACEBO; TRAZODONE; ZOLPIDEM;

ADULT; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CLUMSINESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COORDINATION DISORDER; CROSSOVER PROCEDURE; DISEASE MODEL; DOSE TIME EFFECT RELATION; DRUG EFFECT; ELECTROCARDIOGRAM; ELECTRODE; ELECTROMYOGRAM; EXPERIMENTAL STUDY; FATIGUE; HOME MONITORING; HUMAN; HUMAN EXPERIMENT; INSOMNIA; MALE; NONHUMAN; NORMAL HUMAN; PATIENT COMPLIANCE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RAT; RECORDING; SLEEP; SLEEP INDUCTION; TELEMETRY; VALIDATION PROCESS; VOLUNTEER;

ADULT; ANIMALS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CROSS-OVER STUDIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GABA AGONISTS; HUMANS; HYPNOTICS AND SEDATIVES; MALE; POLYSOMNOGRAPHY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SEROTONIN UPTAKE INHIBITORS; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; TELEMETRY; TRAZODONE;

EID: 33947128584     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0672-0     Document Type: Article

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