Inhibitory effect of calcitonin gene-related peptide on hypoxia-induced rat pulmonary artery smooth muscle cells proliferation: Role of ERK1/2 and p27

European Journal of Pharmacology

Volumn 679, Issue 1-3, 2012, Pages 117-126

  Li, Xian Wei ^a,b   Hu, Chang Ping ^a   Wu, Wei Hua ^a   Zhang, Wei Fang ^a   Zou, Xiao Zhou ^a   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b WANNAN MEDICAL COLLEGE   (China)

Author keywords

Calcitonin gene related peptide; ERK1 2; p27; Proliferation; Pulmonary artery smooth muscle cell; Pulmonary hypertension

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; PROTEIN C FOS; PROTEIN P27;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CGRP GENE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE PRODUCT; HYPOXIA; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ANIMALS; ANOXIA; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HYPERTENSION, PULMONARY; MALE; MAP KINASE SIGNALING SYSTEM; MYOCYTES, SMOOTH MUSCLE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-MYC; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862789010     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.01.015     Document Type: Article

References (33)

1. S.L. Archer, G. Marsboom, G.H. Kim, H.J. Zhang, P.T. Toth, E.C. Svensson, and J.R. Dyck Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target Circulation 121 2010 2661 2671
2. T.J. Bivalacqua, A.L. Hyman, P.J. Kadowitz, N. Paolocci, D.A. Kass, and H.C. Champion Role of calcitonin gene-related peptide (CGRP) in chronic hypoxia-induced pulmonary hypertension in the mouse. Influence of gene transfer in vivo Regul. Pept. 108 2002 129 133 (Pubitemid 35239869)
3. S. Chakraborti, and T. Chakraborti Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: a brief overview Cell. Signal. 10 1998 675 683 (Pubitemid 28520019)
4. H.C. Champion, T.J. Bivalacqua, K. Toyoda, D.D. Heistad, A.L. Hyman, and P.J. Kadowitz In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse Circulation 101 2000 923 930 (Pubitemid 30117889)
5. T. Charron, N. Nili, and B.H. Strauss The cell cycle: a critical therapeutic target to prevent vascular proliferative disease Can. J. Cardiol. 22 2006 41B 55B (Pubitemid 44963571)
6. N.N. Chattergoon, F.M. D'Souza, W. Deng, H. Chen, A.L. Hyman, P.J. Kadowitz, and J.R. Jeter Antiproliferative effects of calcitonin gene-related peptide in aortic and pulmonary artery smooth muscle cells Am. J. Physiol. Lung Cell. Mol. Physiol. 288 2005 L202 211
7. B.K. Dahal, T. Cornitescu, A. Tretyn, S.S. Pullamsetti, D. Kosanovic, R. Dumitrascu, H.A. Ghofrani, N. Weissmann, R. Voswinckel, G.A. Banat, W. Seeger, F. Grimminger, and R.T. Schermuly Role of epidermal growth factor inhibition in experimental pulmonary hypertension Am. J. Respir. Crit. Care Med. 181 2010 158 167
8. W. Deng, R.C. St Hilaire, N.N. Chattergoon, J.R. Jeter Jr., and P.J. Kadowitz Inhibition of vascular smooth muscle cell proliferation in vitro by genetically engineered marrow stromal cells secreting calcitonin gene-related peptide Life Sci. 78 2006 1830 1838
9. L.H. Dong, J.K. Wen, S.B. Miao, Z. Jia, H.J. Hu, R.H. Sun, Y. Wu, and M. Han Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFR beta-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia Cell Res. 20 2010 1252 1262
10. D. Egozi, M. Shapira, G. Paor, O. Ben-Izhak, K. Skorecki, and D.D. Hershko Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells FASEB J. 21 2007 2807 2817 (Pubitemid 47372748)
11. B.W. Fouty, B. Grimison, K.A. Fagan, T.D. Le Cras, J.W. Harral, M. Hoedt-Miller, R.A. Sclafani, and D.M. Rodman p27 (KIP1) is important in modulating pulmonary artery smooth muscle cell proliferation Am. J. Respir. Cell Mol. Biol. 25 2001 652 658 (Pubitemid 33087117)
12. Y. Hou, C. Okamoto, K. Okada, N. Kawao, S. Kawata, S. Ueshima, and O. Matsuo c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells Cardiovasc. Res. 75 2007 186 194 (Pubitemid 46873509)
13. I.M. Keith, A.L.S. Tjen, H. Kraiczi, and R. Ekman Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats Am. J. Physiol. Heart Circ. Physiol. 279 2000 H1571 1578
14. D.J. Klemm, S.M. Majka, J.T. Crossno Jr., J.C. Psilas, J.E. Reusch, and C.V. Garat Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells J. Cardiovasc. Pharmacol. 58 2011 181 191
15. J.G. Lee, and E.P. Kay PI3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2 Invest. Ophthalmol. Vis. Sci. 52 2011 417 426
16. D.J. Lightell Jr., S.C. Moss, and T.C. Woods Loss of canonical insulin signaling accelerates vascular smooth muscle cell proliferation and migration through changes in p27Kip1 regulation Endocrinology 152 2011 651 658
17. X.H. Li, J. Peng, N. Tan, W.H. Wu, T.T. Li, R.Z. Shi, and Y.J. Li Involvement of asymmetric dimethylarginine and Rho kinase in the vascular remodeling in monocrotaline-induced pulmonary hypertension Vascul. Pharmacol. 53 2010 223 229
18. D. Lykouras, F. Sampsonas, A. Kaparianos, G. Efremidis, K. Karkoulias, G. Tsoukalas, and K. Spiropoulos Pulmonary arterial hypertension: need to treat Inflamm. Allergy Drug Targets 7 2008 260 269
19. J.A. Miyake, M. Benadiba, and A. Colquhoun Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression Lipids Health Dis. 8 2009 8
20. J. Perez, R.A. Torres, P. Rocic, M.J. Cismowski, D.S. Weber, V.M. Darley-Usmar, and P.A. Lucchesi PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation Am. J. Physiol. Cell Physiol. 301 2011 C242 C251
21. M. Prabha, H.F. Jin, Y. Tian, C.S. Tang, and J.B. Du Mechanisms responsible for pulmonary hypertension Chin. Med. J. (Engl) 121 2008 2604 2609
22. X.P. Qin, F. Ye, C.P. Hu, D.F. Liao, H.W. Deng, and Y.J. Li Effect of calcitonin gene-related peptide on angiotensin II-induced proliferation of rat vascular smooth muscle cells Eur. J. Pharmacol. 488 2004 45 49 (Pubitemid 38388522)
23. X. Qing, and I.M. Keith Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats Am. J. Physiol. Lung Cell. Mol. Physiol. 285 2003 L86 L96
24. S. Sakao, and K. Tatsumi Vascular remodeling in pulmonary arterial hypertension: multiple cancer-like pathways and possible treatment modalities Int. J. Cardiol. 147 2011 4 12
25. R. Shi, C. Hu, Q. Yuan, T. Yang, J. Peng, Y. Li, Y. Bai, Z. Cao, G. Cheng, and G. Zhang Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation Cardiovasc. Res. 91 2011 27 36
26. S.J. Smillie, and S.D. Brain Calcitonin gene-related peptide (CGRP) and its role in hypertension Neuropeptides 45 2011 93 104
27. Suh, S.J., Jin, U.H., Kim, S.H., Chang, H.W., Son, J.K., Lee, S.H., Son, K.H., Kim, C.H., 2006. Ochnaflavone inhibits TNF-alpha-induced human VSMC proliferation via regulation of cell cycle, ERK1/2, and MMP-9. J. Cell. Biochem. 99, 1298-1307.
28. F.C. Tanner, M. Boehm, L.M. Akyurek, H. San, Z.Y. Yang, J. Tashiro, G.J. Nabel, and E.G. Nabel Differential effects of the cyclin-dependent kinase inhibitors p27 (Kip1), p21 (Cip1), and p16 (Ink4) on vascular smooth muscle cell proliferation Circulation 101 2000 2022 2025 (Pubitemid 30233162)
29. A.L.S. Tjen, H. Kraiczi, R. Ekman, and I.M. Keith Sensory CGRP depletion by capsaicin exacerbates hypoxia-induced pulmonary hypertension in rats Regul. Pept. 74 1998 1 10 (Pubitemid 28234169)
30. M. Vokurkova, S. Xu, and R.M. Touyz Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension Future Cardiol. 3 2007 53 63 (Pubitemid 46157671)
31. L. Yu, D.A. Quinn, H.G. Garg, and C.A. Hales Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia induced pulmonary hypertension and remodeling by heparin in mice Circ. Res. 97 2005 937 945 (Pubitemid 41552680)
32. Q. Zhao, Z. Liu, Z. Wang, C. Yang, J. Liu, and J. Lu Effect of prepro-calcitoningene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension Ann. Thorac. Surg. 84 2007 544 552 (Pubitemid 47069188)
33. B. Zheng, M. Han, M. Bernier, X.H. Zhang, F. Meng, S.B. Miao, M. He, X.M. Zhao, and J.K. Wen Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells J. Biol. Chem. 284 2009 22773 22785