A novel and chemoselective synthesis of substituted 3,4-dihydroisoquinolin- 1(2H)-ones from o-oxiranylmethylbenzonitrile intermediates and TBAB/NaCN

Tetrahedron

Volumn 68, Issue 14, 2012, Pages 3030-3036

  Chen, Po Yuan ^a   Chen, Hsing Ming ^b   Chiang, Michael Y ^c   Wang, You Feng ^a   Li, Sie Rong ^a   Wang, Tzu Pin ^a   Wang, Eng Chi ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b FOOYIN UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

3,4 Dihydroisoquinolin 1(2H) one; Isovanillin; o Oxiranylmethylbenzonitriles; Tandem reaction

Indexed keywords

2 OXIRANYLMETHYLBENZONITRILE; 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 5 BENZYLOXY 3 METHYLCYANO 6 METHOXY 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 5 ETHOXY 3 METHYLCYANO 6 METHOXY 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 5 HYDROXY 3 METHYLCYANO 6 METHOXY 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 5 ISOPENTYLOXY 3 METHYLCYANO 6 METHOXY 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 5 ISOPROPOXY 3 METHYLCYANO 6 METHOXY 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; 5 N BUTOXY 3 METHYLCYANO 6 METHOXY 3,4 DIHYDROISOQUINOLINE 1(2H) ONE; 5,6 DIMETHOXY 3 METHYLCYANO 3,4 DIHYDROISOQUINOLIN 1(2H) ONE; BENZONITRILE; BROMINE DERIVATIVE; EPOXIDE; ISOCHROMAN DERIVATIVE; ISOQUINOLINE DERIVATIVE; ISOVANILLIN; SODIUM CYANIDE; TETRA N BUTYLAMMONIUM BROMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONJUGATE; CYCLIZATION; MICHAEL ADDITION; ONE POT SYNTHESIS; PRIORITY JOURNAL;

EID: 84862787545     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.02.023     Document Type: Article

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