MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer

Cancer Letters

Volumn 320, Issue 2, 2012, Pages 189-197

  Li, Chenglong ^a   Nie, Hui ^a,b   Wang, Ming ^a   Su, Liping ^a   Li, Jianfang ^a   Yu, Beiqin ^a   Wei, Min ^a   Ju, Jingfang ^c   Yu, Yingyan ^a   Yan, Min ^a   Gu, Qinlong ^a   Zhu, Zhenggang ^a   Liu, Bingya ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Gastric cancer; MiR 409 3p; PHF10; Proliferation

Indexed keywords

MICRORNA; MICRORNA 409 3P; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INVASION; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE PHF10; PRIORITY JOURNAL; STOMACH CANCER; STOMACH MUCOSA; TUMOR VOLUME; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MICE, NUDE; MICRORNAS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; STOMACH NEOPLASMS; TRANSFECTION;

EID: 84862787132     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.02.030     Document Type: Article

References (36)

1. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
2. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, D.M. Parkin, GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer. <>, 2010 (accessed 09.16.11). http://globocan.iarc.fr.
3. Moon Y.W., Jeung H.C., Rha S.Y., Yoo N.C., Roh J.K., Noh S.H., Kim B.S., Chung H.C. Changing patterns of prognosticators during 15-year follow-up of advanced gastric cancer after radical gastrectomy and adjuvant chemotherapy: a 15-year follow-up study at a single Korean institute. Ann. Surg. Oncol. 2007, 14:2730-2737.
4. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
5. Kim V.N., Nam J.W. Genomics of microRNA. Trends Genet. 2006, 22:165-173.
6. Croce C.M. Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 2009, 10:704-714.
7. Nicoloso M.S., Spizzo R., Shimizu M., Rossi S., Calin G.A. MicroRNAs - the micro steering wheel of tumour metastases. Nat. Rev. Cancer 2009, 9:293-302.
8. Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
9. Calin G.A., Croce C.M. MicroRNA signatures in human cancers. Nat. Rev. Cancer 2006, 6:857-866.
10. Lewis B.P., Shih I.H., Jones-Rhoades M.W., Bartel D.P., Burge C.B. Prediction of mammalian microRNA targets. Cell 2003, 115:787-798.
11. Zhu S., Wu H., Wu F., Nie D., Sheng S., Mo Y.Y. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 2008, 18:350-359.
12. Johnson S.M., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K.L., Brown D., Slack F.J. RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647.
13. Cimmino A., Calin G.A., Fabbri M., Iorio M.V., Ferracin M., Shimizu M., Wojcik S.E., Aqeilan R.I., Zupo S., Dono M., Rassenti L., Alder H., Volinia S., Liu C.G., Kipps T.J., Negrini M., Croce C.M. MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. USA 2005, 102:13944-13949.
14. Ueda T., Volinia S., Okumura H., Shimizu M., Taccioli C., Rossi S., Alder H., Liu C.G., Oue N., Yasui W., Yoshida K., Sasaki H., Nomura S., Seto Y., Kaminishi M., Calin G.A., Croce C.M. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol. 2010, 11:136-146.
15. Wu W.K., Lee C.W., Cho C.H., Fan D., Wu K., Yu J., Sung J.J. MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene 2010, 29:5761-5771.
16. Li X., Zhang Y., Ding J., Wu K., Fan D. Survival prediction of gastric cancer by a seven-microRNA signature. Gut 2010, 59:579-585.
17. Feng R., Chen X., Yu Y., Su L., Yu B., Li J., Cai Q., Yan M., Liu B., Zhu Z. MiR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett. 2010, 298:50-63.
18. Guo X., Guo L., Ji J., Zhang J., Chen X., Cai Q., Li J., Gu Q., Liu B., Zhu Z., Yu Y. MiRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer. Biochem. Biophys. Res. Commun. 2010, 398:1-6.
19. Ding L., Xu Y., Zhang W., Deng Y., Si M., Du Y., Yao H., Liu X., Ke Y., Si J., Zhou T. MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res. 2010, 20:784-793.
20. Gao C., Zhang Z., Liu W., Xiao S., Gu W., Lu H. Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer. Cancer 2010, 116:41-49.
21. Du Y., Xu Y., Ding L., Yao H., Yu H., Zhou T., Si J. Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. J. Gastroenterol. 2009, 44:556-561.
22. Bou Kheir T., Futoma-Kazmierczak E., Jacobsen A., Krogh A., Bardram L., Hother C., Gronbaek K., Federspiel B., Lund A.H., Friis-Hansen L. MiR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol. Cancer 2011, 10:29.
23. Zhang Z., Li Z., Gao C., Chen P., Chen J., Liu W., Xiao S., Lu H. MiR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab. Invest. 2008, 88:1358-1366.
24. Li X., Zhang Y., Shi Y., Dong G., Liang J., Han Y., Wang X., Zhao Q., Ding J., Wu K., Fan D. MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer. J. Cell. Mol. Med. 2011, 15:1887-1895.
25. Wu Q., Jin H., Yang Z., Luo G., Lu Y., Li K., Ren G., Su T., Pan Y., Feng B., Xue Z., Wang X., Fan D. MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2. Biochem. Biophys. Res. Commun. 2010, 392:340-345.
26. Jin Z., Selaru F.M., Cheng Y., Kan T., Agarwal R., Mori Y., Olaru A.V., Yang J., David S., Hamilton J.P., Abraham J.M., Harmon J., Duncan M., Montgomery E.A., Meltzer S.J. MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. Oncogene 2011, 30:1577-1585.
27. Wei M., Liu B., Su L., Li J., Zhang J., Yu Y., Yan M., Yang Z., Chen X., Liu J., Lv X., Nie H., Zhang Q., Zheng Z., Yu B., Ji J., Zhu Z., Gu Q. A novel plant homeodomain finger 10-mediated antiapoptotic mechanism involving repression of caspase-3 in gastric cancer cells. Mol. Cancer Ther. 2010, 9:1764-1774.
28. Fort A., Borel C., Migliavacca E., Antonarakis S.E., Fish R.J., Neerman-Arbez M. Regulation of fibrinogen production by microRNAs. Blood 2010, 116:2608-2615.
29. Bloomston M., Frankel W.L., Petrocca F., Volinia S., Alder H., Hagan J.P., Liu C.G., Bhatt D., Taccioli C., Croce C.M. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 2007, 297:1901-1908.
30. Shimizu S., Takehara T., Hikita H., Kodama T., Miyagi T., Hosui A., Tatsumi T., Ishida H., Noda T., Nagano H., Doki Y., Mori M., Hayashi N. The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J. Hepatol. 2010, 52:698-704.
31. Tsai K.W., Wu C.W., Hu L.Y., Li S.C., Liao Y.L., Lai C.H., Kao H.W., Fang W.L., Huang K.H., Chan W.C., Lin W.C. Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. Int. J. Cancer 2011, 129:2600-2610.
32. Zheng B., Liang L., Huang S., Zha R., Liu L., Jia D., Tian Q., Wang Q., Wang C., Long Z., Zhou Y., Cao X., Du C., Shi Y., He X. MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. Oncogene 2011, (Epub ahead of print).
33. Breving K., Esquela-Kerscher A. The complexities of microRNA regulation: mirandering around the rules. Int. J. Biochem. Cell Biol. 2010, 42:1316-1329.
34. Aasland R., Gibson T.J., Stewart A.F. The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci. 1995, 20:56-59.
35. Cavalieri D., Dolara P., Mini E., Luceri C., Castagnini C., Toti S., Maciag K., De Filippo C., Nobili S., Morganti M., Napoli C., Tonini G., Baccini M., Biggeri A., Tonelli F., Valanzano R., Orlando C., Gelmini S., Cianchi F., Messerini L., Luzzatto L. Analysis of gene expression profiles reveals novel correlations with the clinical course of colorectal cancer. Oncol. Res. 2007, 16:535-548.
36. Banga S.S., Peng L., Dasgupta T., Palejwala V., Ozer H.L. PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells. Cytogenet. Genome Res. 2009, 126:227-242.