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Volumn 14, Issue 7, 2012, Pages 994-1002

Interaction networks of hepatitis C virus NS4B: Implications for antiviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 4B; PEGINTERFERON ALPHA; RIBAVIRIN; VIRUS PROTEIN;

EID: 84862786200     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2012.01773.x     Document Type: Review
Times cited : (34)

References (64)
  • 3
    • 79961196705 scopus 로고    scopus 로고
    • Charged residues in hepatitis C virus NS4B are critical for multiple NS4B functions in RNA replication
    • Blight, K.J. (2011) Charged residues in hepatitis C virus NS4B are critical for multiple NS4B functions in RNA replication. J Virol 85: 8158-8171.
    • (2011) J Virol , vol.85 , pp. 8158-8171
    • Blight, K.J.1
  • 4
    • 72049111250 scopus 로고    scopus 로고
    • ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains
    • Boleti, H., Smirlis, D., Dalagiorgou, G., Meurs, E.F., Christoforidis, S., and Mavromara, P. (2010) ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains. Mol Membr Biol 27: 50-74.
    • (2010) Mol Membr Biol , vol.27 , pp. 50-74
    • Boleti, H.1    Smirlis, D.2    Dalagiorgou, G.3    Meurs, E.F.4    Christoforidis, S.5    Mavromara, P.6
  • 5
    • 77956255823 scopus 로고    scopus 로고
    • Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication
    • Chen, Y.J., Chen, Y.H., Chow, L.P., Tsai, Y.H., Chen, P.H., Huang, C.Y., etal. (2010) Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication. J Biol Chem 285: 28183-28190.
    • (2010) J Biol Chem , vol.285 , pp. 28183-28190
    • Chen, Y.J.1    Chen, Y.H.2    Chow, L.P.3    Tsai, Y.H.4    Chen, P.H.5    Huang, C.Y.6
  • 6
    • 77953016640 scopus 로고    scopus 로고
    • Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B
    • Cho, N.J., Dvory-Sobol, H., Lee, C., Cho, S.J., Bryson, P., Masek, M., etal. (2010) Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B. Sci Transl Med 2: 15ra16.
    • (2010) Sci Transl Med , vol.2
    • Cho, N.J.1    Dvory-Sobol, H.2    Lee, C.3    Cho, S.J.4    Bryson, P.5    Masek, M.6
  • 7
    • 0037081563 scopus 로고    scopus 로고
    • Protein phosphatase 1 - targeted in many directions
    • Cohen, P.T. (2002) Protein phosphatase 1 - targeted in many directions. J Cell Sci 115: 241-256.
    • (2002) J Cell Sci , vol.115 , pp. 241-256
    • Cohen, P.T.1
  • 9
    • 79952125247 scopus 로고    scopus 로고
    • The future of HCV therapy: NS4B as an antiviral target
    • Dvory-Sobol, H., Pang, P.S., and Glenn, J.S. (2010) The future of HCV therapy: NS4B as an antiviral target. Viruses 2: 2481-2492.
    • (2010) Viruses , vol.2 , pp. 2481-2492
    • Dvory-Sobol, H.1    Pang, P.S.2    Glenn, J.S.3
  • 10
    • 0036100578 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    • Egger, D., Wolk, B., Gosert, R., Bianchi, L., Blum, H.E., Moradpour, D., and Bienz, K. (2002) Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol 76: 5974-5984.
    • (2002) J Virol , vol.76 , pp. 5974-5984
    • Egger, D.1    Wolk, B.2    Gosert, R.3    Bianchi, L.4    Blum, H.E.5    Moradpour, D.6    Bienz, K.7
  • 11
    • 4644222500 scopus 로고    scopus 로고
    • A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication
    • Einav, S., Elazar, M., Danieli, T., and Glenn, J.S. (2004) A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication. J Virol 78: 11288-11295.
    • (2004) J Virol , vol.78 , pp. 11288-11295
    • Einav, S.1    Elazar, M.2    Danieli, T.3    Glenn, J.S.4
  • 12
    • 51349138269 scopus 로고    scopus 로고
    • Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
    • Einav, S., Gerber, D., Bryson, P.D., Sklan, E.H., Elazar, M., Maerkl, S.J., etal. (2008) Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol 26: 1019-1027.
    • (2008) Nat Biotechnol , vol.26 , pp. 1019-1027
    • Einav, S.1    Gerber, D.2    Bryson, P.D.3    Sklan, E.H.4    Elazar, M.5    Maerkl, S.J.6
  • 13
    • 4644281168 scopus 로고    scopus 로고
    • An N-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication
    • Elazar, M., Liu, P., Rice, C.M., and Glenn, J.S. (2004) An N-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication. J Virol 78: 11393-11400.
    • (2004) J Virol , vol.78 , pp. 11393-11400
    • Elazar, M.1    Liu, P.2    Rice, C.M.3    Glenn, J.S.4
  • 14
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller, M. (2008) Epigenetics in cancer. N Engl J Med 358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 15
    • 67949109561 scopus 로고    scopus 로고
    • Prediction of HIV-1 virus - host protein interactions using virus and host sequence motifs
    • Evans, P., Dampier, W., Ungar, L., and Tozeren, A. (2009) Prediction of HIV-1 virus - host protein interactions using virus and host sequence motifs. BMC Med Genomics 2: 27.
    • (2009) BMC Med Genomics , vol.2 , pp. 27
    • Evans, P.1    Dampier, W.2    Ungar, L.3    Tozeren, A.4
  • 16
    • 0036891628 scopus 로고    scopus 로고
    • Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
    • Florese, R.H., Nagano-Fujii, M., Iwanaga, Y., Hidajat, R., and Hotta, H. (2002) Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus. Virus Res 90: 119-131.
    • (2002) Virus Res , vol.90 , pp. 119-131
    • Florese, R.H.1    Nagano-Fujii, M.2    Iwanaga, Y.3    Hidajat, R.4    Hotta, H.5
  • 17
    • 0036189530 scopus 로고    scopus 로고
    • Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors
    • Gaca, M.D., Zhou, X., and Benyon, R.C. (2002) Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol 36: 362-369.
    • (2002) J Hepatol , vol.36 , pp. 362-369
    • Gaca, M.D.1    Zhou, X.2    Benyon, R.C.3
  • 18
    • 1842457783 scopus 로고    scopus 로고
    • Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft
    • Gao, L., Aizaki, H., He, J.W., and Lai, M.M. (2004) Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft. J Virol 78: 3480-3488.
    • (2004) J Virol , vol.78 , pp. 3480-3488
    • Gao, L.1    Aizaki, H.2    He, J.W.3    Lai, M.M.4
  • 19
    • 66149132203 scopus 로고    scopus 로고
    • Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B
    • Gouttenoire, J., Castet, V., Montserret, R., Arora, N., Raussens, V., Ruysschaert, J.M., etal. (2009) Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B. J Virol 83: 6257-6268.
    • (2009) J Virol , vol.83 , pp. 6257-6268
    • Gouttenoire, J.1    Castet, V.2    Montserret, R.3    Arora, N.4    Raussens, V.5    Ruysschaert, J.M.6
  • 20
    • 78649398569 scopus 로고    scopus 로고
    • Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B
    • Gouttenoire, J., Roingeard, P., Penin, F., and Moradpour, D. (2010a) Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B. J Virol 84: 12529-12537.
    • (2010) J Virol , vol.84 , pp. 12529-12537
    • Gouttenoire, J.1    Roingeard, P.2    Penin, F.3    Moradpour, D.4
  • 21
    • 77649175920 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory
    • Gouttenoire, J., Penin, F., and Moradpour, D. (2010b) Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory. Rev Med Virol 20: 117-129.
    • (2010) Rev Med Virol , vol.20 , pp. 117-129
    • Gouttenoire, J.1    Penin, F.2    Moradpour, D.3
  • 23
    • 80052056964 scopus 로고    scopus 로고
    • Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication
    • Han, Q., Aligo, J., Manna, D., Belton, K., Chintapalli, S.V., Hong, Y., etal. (2011) Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication. J Virol 85: 6464-6479.
    • (2011) J Virol , vol.85 , pp. 6464-6479
    • Han, Q.1    Aligo, J.2    Manna, D.3    Belton, K.4    Chintapalli, S.V.5    Hong, Y.6
  • 24
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He, C., and Klionsky, D.J. (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 25
    • 79957485296 scopus 로고    scopus 로고
    • Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome
    • Herceg, Z., and Paliwal, A. (2011) Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. Mutat Res 727: 55-61.
    • (2011) Mutat Res , vol.727 , pp. 55-61
    • Herceg, Z.1    Paliwal, A.2
  • 26
    • 0030928695 scopus 로고    scopus 로고
    • Hepatitis C: the clinical spectrum of disease
    • Hoofnagle, J.H. (1997) Hepatitis C: the clinical spectrum of disease. Hepatology 26: 15S-20S.
    • (1997) Hepatology , vol.26
    • Hoofnagle, J.H.1
  • 27
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J.D., Goldstein, J.L., and Brown, M.S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 28
    • 0242624460 scopus 로고    scopus 로고
    • The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein
    • Hugle, T., Fehrmann, F., Bieck, E., Kohara, M., Krausslich, H.G., Rice, C.M., etal. (2001) The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein. Virology 284: 70-81.
    • (2001) Virology , vol.284 , pp. 70-81
    • Hugle, T.1    Fehrmann, F.2    Bieck, E.3    Kohara, M.4    Krausslich, H.G.5    Rice, C.M.6
  • 29
    • 0034657945 scopus 로고    scopus 로고
    • Preface: STAT signaling
    • Jove, R. (2000) Preface: STAT signaling. Oncogene 19: 2466-2467.
    • (2000) Oncogene , vol.19 , pp. 2466-2467
    • Jove, R.1
  • 30
    • 0036139053 scopus 로고    scopus 로고
    • Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo
    • Kato, J., Kato, N., Yoshida, H., Ono-Nita, S.K., Shiratori, Y., and Omata, M. (2002) Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo. J Med Virol 66: 187-199.
    • (2002) J Med Virol , vol.66 , pp. 187-199
    • Kato, J.1    Kato, N.2    Yoshida, H.3    Ono-Nita, S.K.4    Shiratori, Y.5    Omata, M.6
  • 31
    • 77649298360 scopus 로고    scopus 로고
    • Prevalence of genetic polymorphisms in the promoter region of the alpha-1 antitrypsin (SERPINA1) gene in chronic liver disease: a case control study
    • Kok, K.F., te Morsche, R.H., van Oijen, M.G., and Drenth, J.P. (2010) Prevalence of genetic polymorphisms in the promoter region of the alpha-1 antitrypsin (SERPINA1) gene in chronic liver disease: a case control study. BMC Gastroenterol 10: 22.
    • (2010) BMC Gastroenterol , vol.10 , pp. 22
    • Kok, K.F.1    te Morsche, R.H.2    van Oijen, M.G.3    Drenth, J.P.4
  • 32
    • 64249133886 scopus 로고    scopus 로고
    • Chemoprevention of rat hepatocarcinogenesis with histone deacetylase inhibitors: efficacy of tributyrin, a butyric acid prodrug
    • Kuroiwa-Trzmielina, J., de Conti, A., Scolastici, C., Pereira, D., Horst, M.A., Purgatto, E., etal. (2009) Chemoprevention of rat hepatocarcinogenesis with histone deacetylase inhibitors: efficacy of tributyrin, a butyric acid prodrug. Int J Cancer 124: 2520-2527.
    • (2009) Int J Cancer , vol.124 , pp. 2520-2527
    • Kuroiwa-Trzmielina, J.1    de Conti, A.2    Scolastici, C.3    Pereira, D.4    Horst, M.A.5    Purgatto, E.6
  • 33
    • 68549086862 scopus 로고    scopus 로고
    • Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation
    • Li, S., Ye, L., Yu, X., Xu, B., Li, K., Zhu, X., etal. (2009) Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation. Virology 391: 257-264.
    • (2009) Virology , vol.391 , pp. 257-264
    • Li, S.1    Ye, L.2    Yu, X.3    Xu, B.4    Li, K.5    Zhu, X.6
  • 34
    • 67650735846 scopus 로고    scopus 로고
    • Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain
    • Liefhebber, J.M., Brandt, B.W., Broer, R., Spaan, W.J., and van Leeuwen, H.C. (2009) Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain. Virol J 6: 62.
    • (2009) Virol J , vol.6 , pp. 62
    • Liefhebber, J.M.1    Brandt, B.W.2    Broer, R.3    Spaan, W.J.4    van Leeuwen, H.C.5
  • 35
    • 0344373790 scopus 로고    scopus 로고
    • Topology of the membrane-associated hepatitis C virus protein NS4B
    • Lundin, M., Monne, M., Widell, A., Von Heijne, G., and Persson, M.A. (2003) Topology of the membrane-associated hepatitis C virus protein NS4B. J Virol 77: 5428-5438.
    • (2003) J Virol , vol.77 , pp. 5428-5438
    • Lundin, M.1    Monne, M.2    Widell, A.3    Von Heijne, G.4    Persson, M.A.5
  • 36
    • 33750249579 scopus 로고    scopus 로고
    • Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein
    • Lundin, M., Lindstrom, H., Gronwall, C., and Persson, M.A. (2006) Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein. J Gen Virol 87: 3263-3272.
    • (2006) J Gen Virol , vol.87 , pp. 3263-3272
    • Lundin, M.1    Lindstrom, H.2    Gronwall, C.3    Persson, M.A.4
  • 37
    • 76049106065 scopus 로고    scopus 로고
    • Endocytic Rab proteins are required for hepatitis C virus replication complex formation
    • Manna, D., Aligo, J., Xu, C., Park, W.S., Koc, H., Heo, W.D., and Konan, K.V. (2010) Endocytic Rab proteins are required for hepatitis C virus replication complex formation. Virology 398: 21-37.
    • (2010) Virology , vol.398 , pp. 21-37
    • Manna, D.1    Aligo, J.2    Xu, C.3    Park, W.S.4    Koc, H.5    Heo, W.D.6    Konan, K.V.7
  • 38
    • 80052166468 scopus 로고    scopus 로고
    • Impact of the autophagy machinery on hepatitis C virus infection
    • Marlène Dreux, F.V.C. (2011) Impact of the autophagy machinery on hepatitis C virus infection. Viruses 3: 1342-1357.
    • (2011) Viruses , vol.3 , pp. 1342-1357
    • Marlène Dreux, F.V.C.1
  • 39
    • 0035030510 scopus 로고    scopus 로고
    • SH3 domains: complexity in moderation
    • Mayer, B.J. (2001) SH3 domains: complexity in moderation. J Cell Sci 114: 1253-1263.
    • (2001) J Cell Sci , vol.114 , pp. 1253-1263
    • Mayer, B.J.1
  • 41
    • 44949154435 scopus 로고    scopus 로고
    • Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A
    • Moriyama, M., Kato, N., Otsuka, M., Shao, R.X., Taniguchi, H., Kawabe, T., and Omata, M. (2007) Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A. Hepatol Int 1: 302-310.
    • (2007) Hepatol Int , vol.1 , pp. 302-310
    • Moriyama, M.1    Kato, N.2    Otsuka, M.3    Shao, R.X.4    Taniguchi, H.5    Kawabe, T.6    Omata, M.7
  • 42
    • 33645797382 scopus 로고    scopus 로고
    • Epigenetic silencing of interferon-inducible genes is implicated in interferon resistance of hepatitis C virus replicon-harboring cells
    • Naka, K., Abe, K., Takemoto, K., Dansako, H., Ikeda, M., Shimotohno, K., and Kato, N. (2006) Epigenetic silencing of interferon-inducible genes is implicated in interferon resistance of hepatitis C virus replicon-harboring cells. J Hepatol 44: 869-878.
    • (2006) J Hepatol , vol.44 , pp. 869-878
    • Naka, K.1    Abe, K.2    Takemoto, K.3    Dansako, H.4    Ikeda, M.5    Shimotohno, K.6    Kato, N.7
  • 43
    • 66149149803 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway
    • Park, C.Y., Jun, H.J., Wakita, T., Cheong, J.H., and Hwang, S.B. (2009) Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway. J Biol Chem 284: 9237-9246.
    • (2009) J Biol Chem , vol.284 , pp. 9237-9246
    • Park, C.Y.1    Jun, H.J.2    Wakita, T.3    Cheong, J.H.4    Hwang, S.B.5
  • 44
    • 0034684968 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene
    • Park, J.S., Yang, J.M., and Min, M.K. (2000) Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene. Biochem Biophys Res Commun 267: 581-587.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 581-587
    • Park, J.S.1    Yang, J.M.2    Min, M.K.3
  • 45
    • 77956397284 scopus 로고    scopus 로고
    • Role of lipid metabolism in hepatitis C virus assembly and entry
    • Popescu, C.I., and Dubuisson, J. (2010) Role of lipid metabolism in hepatitis C virus assembly and entry. Biol Cell 102: 63-74.
    • (2010) Biol Cell , vol.102 , pp. 63-74
    • Popescu, C.I.1    Dubuisson, J.2
  • 46
    • 79955647061 scopus 로고    scopus 로고
    • New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B
    • Rai, R., and Deval, J. (2011) New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B. Antiviral Res 90: 93-101.
    • (2011) Antiviral Res , vol.90 , pp. 93-101
    • Rai, R.1    Deval, J.2
  • 47
    • 84856032592 scopus 로고    scopus 로고
    • New insights into HCV replication: potential antiviral targets
    • Rice, C.M. (2011) New insights into HCV replication: potential antiviral targets. Top Antivir Med 19: 117-120.
    • (2011) Top Antivir Med , vol.19 , pp. 117-120
    • Rice, C.M.1
  • 48
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schroder, M., and Kaufman, R.J. (2005) ER stress and the unfolded protein response. Mutat Res 569: 29-63.
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 49
    • 0032731641 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation
    • Shimoike, T., Mimori, S., Tani, H., Matsuura, Y., and Miyamura, T. (1999) Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation. J Virol 73: 9718-9725.
    • (1999) J Virol , vol.73 , pp. 9718-9725
    • Shimoike, T.1    Mimori, S.2    Tani, H.3    Matsuura, Y.4    Miyamura, T.5
  • 50
    • 34247559591 scopus 로고    scopus 로고
    • Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery
    • Stone, M., Jia, S., Heo, W.D., Meyer, T., and Konan, K.V. (2007) Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol 81: 4551-4563.
    • (2007) J Virol , vol.81 , pp. 4551-4563
    • Stone, M.1    Jia, S.2    Heo, W.D.3    Meyer, T.4    Konan, K.V.5
  • 52
    • 80054978956 scopus 로고    scopus 로고
    • Rab5 and class III PI-3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy
    • Su, W.C., Chao, T.C., Huang, Y.L., Weng, S.C., Jeng, K.S., and Lai, M.M. (2011) Rab5 and class III PI-3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol 85: 10561-10571.
    • (2011) J Virol , vol.85 , pp. 10561-10571
    • Su, W.C.1    Chao, T.C.2    Huang, Y.L.3    Weng, S.C.4    Jeng, K.S.5    Lai, M.M.6
  • 53
    • 73249118526 scopus 로고    scopus 로고
    • Hepatitis C virus hijacks host lipid metabolism
    • Syed, G.H., Amako, Y., and Siddiqui, A. (2010) Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab 21: 33-40.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 33-40
    • Syed, G.H.1    Amako, Y.2    Siddiqui, A.3
  • 54
    • 36749012903 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response
    • Tasaka, M., Sakamoto, N., Itakura, Y., Nakagawa, M., Itsui, Y., Sekine-Osajima, Y., etal. (2007) Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response. J Gen Virol 88: 3323-3333.
    • (2007) J Gen Virol , vol.88 , pp. 3323-3333
    • Tasaka, M.1    Sakamoto, N.2    Itakura, Y.3    Nakagawa, M.4    Itsui, Y.5    Sekine-Osajima, Y.6
  • 55
    • 70349960028 scopus 로고    scopus 로고
    • Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells
    • Tatebe, H., Shimizu, M., Shirakami, Y., Sakai, H., Yasuda, Y., Tsurumi, H., and Moriwaki, H. (2009) Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells. Cancer Lett 285: 210-217.
    • (2009) Cancer Lett , vol.285 , pp. 210-217
    • Tatebe, H.1    Shimizu, M.2    Shirakami, Y.3    Sakai, H.4    Yasuda, Y.5    Tsurumi, H.6    Moriwaki, H.7
  • 56
    • 61449111949 scopus 로고    scopus 로고
    • Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity
    • Thompson, A.A., Zou, A., Yan, J., Duggal, R., Hao, W., Molina, D., etal. (2009) Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity. Biochemistry 48: 906-916.
    • (2009) Biochemistry , vol.48 , pp. 906-916
    • Thompson, A.A.1    Zou, A.2    Yan, J.3    Duggal, R.4    Hao, W.5    Molina, D.6
  • 59
    • 79551562879 scopus 로고    scopus 로고
    • Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction network
    • te Velthuis, A.J., Sakalis, P.A., Fowler, D.A., and Bagowski, C.P. (2011) Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction network. PLoS ONE 6: e16047.
    • (2011) PLoS ONE , vol.6
    • te Velthuis, A.J.1    Sakalis, P.A.2    Fowler, D.A.3    Bagowski, C.P.4
  • 60
    • 1642441710 scopus 로고    scopus 로고
    • Two-step affinity purification of the hepatitis C virus ribonucleoprotein complex
    • Waris, G., Sarker, S., and Siddiqui, A. (2004) Two-step affinity purification of the hepatitis C virus ribonucleoprotein complex. RNA 10: 321-329.
    • (2004) RNA , vol.10 , pp. 321-329
    • Waris, G.1    Sarker, S.2    Siddiqui, A.3
  • 61
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • Waris, G., Felmlee, D.J., Negro, F., and Siddiqui, A. (2007) Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol 81: 8122-8130.
    • (2007) J Virol , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4
  • 62
    • 34548301522 scopus 로고    scopus 로고
    • Structural and functional comparison of the non-structural protein 4B in flaviviridae
    • Welsch, C., Albrecht, M., Maydt, J., Herrmann, E., Welker, M.W., Sarrazin, C., etal. (2007) Structural and functional comparison of the non-structural protein 4B in flaviviridae. J Mol Graph Model 26: 546-557.
    • (2007) J Mol Graph Model , vol.26 , pp. 546-557
    • Welsch, C.1    Albrecht, M.2    Maydt, J.3    Herrmann, E.4    Welker, M.W.5    Sarrazin, C.6
  • 63
    • 33744921881 scopus 로고    scopus 로고
    • Palmitoylation and polymerization of hepatitis C virus NS4B protein
    • Yu, G.Y., Lee, K.J., Gao, L., and Lai, M.M. (2006) Palmitoylation and polymerization of hepatitis C virus NS4B protein. J Virol 80: 6013-6023.
    • (2006) J Virol , vol.80 , pp. 6013-6023
    • Yu, G.Y.1    Lee, K.J.2    Gao, L.3    Lai, M.M.4
  • 64
    • 20444445185 scopus 로고    scopus 로고
    • Gene expression profiles of HeLa cells impacted by hepatitis C virus non-structural protein NS4B
    • Zheng, Y., Ye, L.B., Liu, J., Jing, W., Timani, K.A., Yang, X.J., etal. (2005) Gene expression profiles of HeLa cells impacted by hepatitis C virus non-structural protein NS4B. J Biochem Mol Biol 38: 151-160.
    • (2005) J Biochem Mol Biol , vol.38 , pp. 151-160
    • Zheng, Y.1    Ye, L.B.2    Liu, J.3    Jing, W.4    Timani, K.A.5    Yang, X.J.6


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