Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation

Journal of Virology

Volumn 73, Issue 12, 1999, Pages 9718-9725

  Shimoike, Takashi ^a   Mimori, Shigetaka ^a   Tani, Hideki ^a   Matsuura, Yoshiharu ^a   Miyamura, Tatsuo ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; VIRUS RNA;

ARTICLE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; REPORTER GENE; RNA TRANSLATION; VIRUS MORPHOGENESIS; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

EID: 0032731641     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.12.9718-9725.1999     Document Type: Article

References (62)

1. Aizaki, H., Y. Aoki, T. Harada, K. Ishii, T. Suzuki, S. Nagamori, G. Toda, Y. Matsuura, and T. Miyamura. 1998. Full-length complementary DNA of hepatitis C virus genome from an infectious blood sample. Hepatology 27: 621-627.
2. Ali, N., and A. Siddiqui. 1995. Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J. Virol. 69:6367-6375.
3. Ali, N., and A. Siddiqui. 1997. The La antigen binds 5′ noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation. Proc. Natl. Acad. Sci. USA 94:2249-2254.
4. Alter, M. J., H. S. Margolis, K. Krawczynski, F. N. Judson, A. Mares, W. J. Alexander, P. Y. Hu, J. K. Miller, M. A. Gerber, R. E. Sampliner, E. L. Meeks, and M. J. Beach. 1992. The natural history of community-acquired hepatitis C in the United States. N. Engl. J. Med. 327:1899-1905.
5. Aoki, Y., H. Aizaki, T. Shimoike, H. Tani, K. Ishii, I. Saito, Y. Matsuura, and T. Miyamura. 1998. A human liver cell line exhibits efficient translation of HCV RNAs produced by a recombinant adenovirus expressing T7 RNA polymerase. Virology 250:140-150.
6. Baric, R., G. Nelson, J. Fleming, R. Deans, J. Keck, N. Casteel, and S. Stohlman. 1988. Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription. J. Virol. 62:4280-4287.
7. Baumert, T., S. Ito, D. Wong, and T. Liang. 1998. Hepatitis C virus structural proteins assemble into viruslike particles in insect cells. J. Virol. 72:3827-3836.
8. Bukh, J., R. Purcell, and R. Miller. 1992. Sequence analysis of the 5′ non-coding region of hepatitis C virus. Proc. Natl. Acad. Sci. USA 89:4942-4946.
9. Chen, C., L. You, L. Hwang, and Y. Lee. 1997. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-β receptor modulates the signal pathway of the lymphotoxin-β receptor. J. Virol. 71:9417-9426.
10. Choo, Q.-L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
11. Choo, Q.-L., K. H. Richman, J. H. Han, K. Berger, C. Lee, C. Dong, C. Gallegos, D. Coit, A. Medina-Selby, P. J. Barr, A. J. Weiner, D. W. Bradley, G. Kuo, and M. Houghton. 1991. Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA 88:2451-2455.
12. Clarke, B. 1997. Molecular virology of hepatitis C virus. J. Gen. Virol. 78: 2397-2410.
13. Dash, S., A. B. Halim, H. Tsuji, N. Hiramatsu, and M. Gerber. 1997. Transfection of Hep G2 cells with infectious hepatitis C virus genome. Am. J. Pathol. 151:363-373.
14. Fukushi, S., C. Kurihara, N. Ishiyama, F. Hoshino, A. Oya, and K. Katayama. 1997. The sequence element of the internal ribosome entry site and a 25-kilodalton cellular protein contribute to efficient internal initiation of translation of hepatitis C virus RNA. J. Virol. 71:1662-1666.
15. Geigenmuller-Gnirke, U., H. Nitschko, and S. Schlesinger. 1993. Deletion analysis of the capsid protein of Sindbis virus: identification of the RNA binding region. J. Virol. 67:1620-1626.
16. Grakoui, A., D. W. McCourt, C. Wychowski, S. M. Feinstone, and C. M. Rice. 1993. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J. Virol. 67:2832-2843.
17. Hijikata, M., N. Kato, Y. Ootsuyama, M. Nakagawa, and K. Shimotohno. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88: 5547-5551.
18. Houghton, M., A. Weiner, J. Han, G. Kuo, and Q.-L. Choo. 1991. Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology 14:381-388.
19. Hwang, S. B., S. Y. Lo, and M. M. C. Lai. 1995. Detection of cellular proteins and viral core protein interacting with the 5′ untranslated region of hepatitis C virus RNA. J. Biomed. Sci. 2:227-236.
20. Ito, T., J. Mukaigawa, J. Zuo, Y. Hirabayashi, K. Mitamura, and K. Yasui. 1996. Cultivation of hepatitis C virus in primary hepatocyte culture from patients with chronic hepatitis C results in release of high titer infectious virus. J. Gen. Virol. 77:1043-1054.
21. Kashiwakuma, T., A. Hasegawa, T. Kajita, A. Takata, H. Mori, Y. Ohta, E. Tanaka, K. Kiyosawa, T. Tanaka, S. Tanaka, N. Hattori, and M. Kohara. 1996. Detection of hepatitis C virus specific core protein in serum of patients by a sensitive fluorescence enzyme immunoassay (FEIA). J. Immunol. Methods 190:79-89.
22. Kato, N., M. Hijikata, Y. Ootsuyama, M. Nakagawa, S. Ohkoshi, T. Sugimura, and K. Shimotohno. 1990. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. USA 87:9524-9528.
23. Kato, N., T. Nakazawa, T. Mizutani, and K. Shimotohno. 1995. Susceptibility of human T-lymphotropic virus type I infected cell line MT-2 to hepatic C virus infection. Biochem. Biophys. Res. Commun. 206:863-869.
24. Kim, D. W., R. Suzuki, T. Harada, I. Saito, and T. Miyamura. 1994. Trans-suppression of gene expression by hepatitis C viral core protein. Jpn. J. Med. Sci. Biol. 47:211-220.
25. Kolykhalov, A. A., E. V. Agapov, K. J. Blight, K. Mihalik, S. M. Feinstone, and C. M. Rice. 1997. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 277:570-574.
26. Kno, G., Q.-L. Choo, H. J. Alter, G. L. Gitnick, A. G. Redeker, R. H. Purcell, T. Miyamura, J. L. Dienstag, M. J. Alter, C. E. Stevens, G. E. Tegtmeier, F. Bonino, M. Colombo, W.-S. Lee, C. Kuo, K. Berger, F. R. Shuster, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362-364.
27. Large, M. K., D. J. Kittlesen, and Y. S. Hahn. 1999. Suppression of host immune response by the core protein of hepatitis C virus: implications for hepatitis C virus persistence. J. Immunol. 162:931-938.
28. Liu, Z., D. Yang, Z. Qiu, K. Lim, P. Chong, and S. Gillam. 1996. Identification of domains in rubella virus genomic RNA and capsid protein necessary for specific interaction. J. Virol. 70:2184-2190.
29. Lo, S. Y., M. J. Selby, and J. H. Ou. 1996. Interaction between hepatitis C virus core protein and E1 envelope protein. J. Virol. 70:5177-5182.
30. Masters, P. 1992. Localization of an RNA-binding domain in the nucleo-capsid protein of the coronavirus mouse hepatitis virus. Arch. Virol. 125: 141-160.
31. Matsumoto, M., T.-Y. Hsieh, N. Zhu, T. Van Arsdale, S. B. Hwang, K.-S. Jeng, A. E. Gorbalenya, S.-Y. Lo, J.-H. Ou, C. F. Ware, and M. M. C. Lai. 1997. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-β receptor. J. Virol. 71:1301-1309.
32. Matsumoto, M., S. Hwang, K. Jeng, N. Zhu, and M. M. Lai. 1996. Homotypic interaction and multimerization of hepatitis C virus core protein. Virology 218:43-51.
33. Miller, R. H., and R. H. Purcell. 1990. Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc. Natl. Acad. Sci. USA 87:2057-2061.
34. Moradpour, D., C. Englert, T. Wakita, and J. R. Wands. 1996. Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein. Virology 222:51-63.
35. Moriya, K., H. Fujie, H. Yotsuyanagi, Y. Shintani, T. Tsutsumi, K. Ishibashi, Y. Matsuura, S. Kimura, T. Miyamura, and K. Koike. 1998. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat. Med. 4:1065-1067.
36. Moriya, K., H. Yotsuyanagi, K. Ishibashi, Y. Shintani, H. Fujie, Y. Matsuura, T. Miyamura, and K. Koike. 1997. Hepatitis C virus core protein induces steatosis in transgenic mice. J. Gen. Virol. 78:1527-1531.
37. Moss, B., O. Elroy-Stein, T. Mizukami, W. Alexander, and T. Fuerst. 1990. Product review. New mammalian expression vectors. Nature 348:91-92.
38. Niwa, H., K. Yamamura, and J. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-200.
39. Ray, R. B., L. M. Lagging, K. Meyer, and R. Ray. 1996. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J. Virol. 70:4438-4443.
40. Ray, R B., L. M. Lagging, K. Meyer, R. Steele, and R. Ray. 1995. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 37:209-220.
41. Ray, R., K. Meyer, and R. Ray. 1996. Suppression of apoptotic cell death by hepatitis C virus core protein. Virology 226:176-182.
42. WAF1/Cip1/Sid1 promoter activity. Gene 208:331-336.
43. Reynolds, J. E., A. Kaminski, H. Kettinen, K. Grace, B. Clarke, A. Carroll, D. Rowlands, and R. Jackson. 1995. Unique features of internal initiation of hepatitis C virus RNA translation. EMBO J. 14:6010-6020.
44. Ruggieri, A., T. Harada, Y. Matsuura, and T. Miyamura. 1997. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology 229: 68-76.
45. Saito, I., T. Miyamura, A. Ohbayashi, H. Harada, T. Katayama, S. Kikuchi, Y. Watanabe, S. Koi, M. Onji, Y. Ohta, Q.-L. Choo, M. Houghton, and G. Kuo. 1990. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87:6547-6549.
46. Santolini, E., G. Migliaccio, and N. La Monica. 1994. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol. 68: 3631-3641.
47. Shimizu, Y. K., A. Iwamoto, M. Hijikata, R. H. Purcell, and H. Yoshikura. 1992. Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line. Proc. Natl. Acad. Sci. USA 89:5477-5481.
48. Shih, C.-M., S. J. Lo, T. Miyamura, S.-Y. Chen, and Y.-H. W. Lee. 1993. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J. Virol. 67:5823-5832.
49. Shoji, I., H. Aizaki, H. Tani, K. Ishii, T. Chiba, I. Saito, T. Miyamura, and Y. Matsuura. 1997. Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. J. Gen. Virol. 78:2657-2664.
50. Shoji, I., T. Suzuki, M. Sato, H. Aizaki, T. Chiba, Y. Matsuura, and T. Miyamura. 1999. Internal processing of hepatitis C virus NS3 protein. Virology 254:315-323.
51. Sizova, D., V. Kolupaeva, T. Pestova, I. Shatsky, and C. Hellen. 1998. Specific interaction of eukaryotic translation initiation factor 3 with the 5′ non-translated regions of hepatitis C virus and classical swine fever virus RNAs. J. Virol. 72:4775-4782.
52. gag. J. Virol. 70:6642-6652.
53. Stohlman, S., R. Baric, G. Nelson, L. Soe, L. Welter, and R. Deans. 1988. Specific interaction between coronavirus leader RNA and nucleocapsid protein. J. Virol. 62:4288-4295.
54. Suzuki, R., Y. Matsuura, T. Suzuki, A. Ando, J. Chiba, S. Harada, I. Saito, and T. Miyamura. 1995. Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted. J. Gen. Virol. 76: 53-61.
55. Takamizawa, A., C. Mori, I. Fuke, S. Manabe, S. Murakami, J. Fujita, E. Onishi, T. Andoh, I. Yoshida, and H. Okayama. 1991. Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 45:1105-1113.
56. Takeuchi, K., S. Boonmar, Y. Kubo, T. Katayama, H. Harada, A. Ohbayashi, Q.-L. Choo, G. Kuo, M. Houghton, I. Saito, and T. Miyamura. 1990. Hepatitis C virus cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene 91:287-291.
57. Tsukiyama-Kohara, K., N. Iizuka, M. Kohara, and A. Nomoto. 1992. Internal ribosome entry site within hepatitis C virus RNA. J. Virol. 66: 1476-1483.
58. Weiss, B., H. Nitschko, I. Ghattas, R. Wright, and S. Schlesinger. 1989. Evidence for specificity in the encapsidation of Sindbis virus RNAs. J. Virol. 63:5310-5318.
59. Weiss, B., U. Geigenmuller-Gnirke, and S. Schlesinger. 1994. Interactions between Sindbis virus RNAs and a 68 amino acid derivative of the viral capsid protein further defines the capsid binding site. Nucleic Acids Res 22: 780-786.
60. Yanagi, M., R. H. Purcell, S. U. Emerson, and J. Bukh. 1997. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc. Natl. Acad. Sci. USA 94:8738-8743.
61. Yap, C. C., K. Ishii, H. Aizaki, H. Tani, Y. Aoki, Y. Ueda, Y. Matsuura, and T. Miyamura. 1998. Expression of target genes by coinfection with replication-deficient viral vectors. J. Gen. Virol. 79:1879-1888.
62. Zhu, N., A. Khoshnan, R. Schneider, M. Matsumoto, G. Dennert C. Ware, and M. M. Lai. 1998. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J. Virol. 72:3691-3697.